A5105352851- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Helicobacter pylori-related gastroenterology studies
- Aquaculture Nutrition and Growth
- Nerve injury and regeneration
- Ion channel regulation and function
- Cardiac Valve Diseases and Treatments
- Receptor Mechanisms and Signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Apelin-related biomedical research
- Hereditary Neurological Disorders
- Axon Guidance and Neuronal Signaling
- Traditional Chinese Medicine Analysis
- Sperm and Testicular Function
- Nitric Oxide and Endothelin Effects
- Electrospun Nanofibers in Biomedical Applications
- Steroid Chemistry and Biochemistry
- Galectins and Cancer Biology
- Ion Channels and Receptors
- Cell Adhesion Molecules Research
- Acupuncture Treatment Research Studies
- Anesthesia and Pain Management
- Medicinal Plants and Bioactive Compounds
- Myofascial pain diagnosis and treatment
- Neurogenesis and neuroplasticity mechanisms
Dalian Medical University
2024
Peking University
2024
Nanjing Medical University
2023
Jiangsu Province Hospital
2023
Guangxi Academy of Fishery Sciences
2021
Guangxi University
2021
Zhejiang University
2021
Chinese Academy of Sciences
2003-2017
Shanghai Institutes for Biological Sciences
2003-2017
ShanghaiTech University
2017
Abstract Using immunohistochemistry and in situ hybridization, we studied changes expression of some neuropeptides large medium‐sized neurons lumbar 4 5 rat dorsal root ganglia projecting to the gracile nucleus, response peripheral axotomy. Fourteen days after unilateral sciatic nerve transection, many ipsilateral were strongly neuropeptide Y‐positive. Galanin‐, vasoactive intestinal polypeptide (VIP)‐ peptide histidine‐isoleucine (PHI)‐like immunoreactivities coexisted with Y‐like...
Opiate abuse causes adaptive changes in several processes of synaptic transmission which the glutamatergic system appears a critical element involved opiate tolerance and dependence, but underlying mechanisms remain unclear. In present study, we found that glutamate uptake hippocampal synaptosomes was significantly increased (by 70% chronic morphine-treated rats) during morphine withdrawal period, likely attributable to an increase number functional transporters. Immunoblot analysis showed...
Patients with atrophic gastritis (AG) or gastric intestinal metaplasia (GIM) have elevated risk of adenocarcinoma. Endoscopic screening and surveillance been implemented in high incidence countries. The study aimed to evaluate the accuracy a deep convolutional neural network (CNN) for simultaneous recognition AG GIM.Archived endoscopic white light images corresponding biopsies were collected from 14 hospitals located different regions China. Corresponding by anatomic sites containing AG,...
Emerging evidence suggests that the suppressive modulators released from nociceptive afferent neurons contribute to pain regulation. However, expressed in small-diameter of dorsal root ganglion remain be further identified. The present study shows activin C small is required for suppressing inflammation-induced responses. expression rats was markedly downregulated during early days peripheral inflammation induced by intraplantar injection complete Freund's adjuvant. Intrathecal treatment...
Using immunohistochemistry and in situ hybridization the expression of calcitonin gene-related peptide (CGRP) was studied mouse spinal cord under normal conditions after unilateral rhizotomy local colchicine treatment. Under a dense plexus CGRP-immunoreactive (IR) fibres observed superfical layers dorsal horns with lower numbers fibers deeper laminae. Seven days rhizotomy, there marked reduction CGRP-IR ipsilateral distinctly neurons could be detected lamina III. CGRP mRNA-positive were III...
Clinical and preclinical studies have implicated serotonin (5-HT) the 5-HT2A receptor (5-HT2AR) in pathogenesis of medication-overuse headache (MOH). However, with no appropriate animal model to study this phenomenon it is difficult differentiate effects chronic exposure analgesics from consequences frequent attacks during development MOH. Therefore, used a novel MOH established by combination overuse rizatriptan (RIZ) stimulation dural inflammatory soup (IS) investigate whether 5-HT 5-HT2AR...
The effect of three peptides, galanin, sulfated cholecystokinin octapeptide, and neurotensin (NT), was studied on acutely extirpated rat dorsal root ganglia (DRGs) in vitro with intracellular recording techniques. Both normal peripherally axotomized DRGs were analyzed, recordings made from C-type (small) A-type (large) neurons. Galanin one exception, had no C- neurons but caused an inward current both types after sciatic nerve cut. In rats, NT outward After cut, only These results suggest...
This study was explored the supplementary of vitamin E on reproduction tilapia. Five supplements (0, 40, 80, 120 and 160 mg/kg) were tested for 90 days. Results: The SGR, GSI ovarian maturity female highest at Group mg/kg, FCR lowest. testis male levels FSH P significantly increased mg/kg in female, E2 reached maximum. T GnRH male. expression FSHR liver ovary 40 mg/kg. pgr kidney 80 In conclusion, can regulate secretion reproductive hormones during different developmental stages tilapia,...
Abstract Targeted therapy is pivotal in renal carcinoma treatment, and the dual-inhibitor NVP-BEZ235 has emerged as a promising candidate preliminary studies. Its effectiveness against mechanisms underlying potential resistance, however, warrant further exploration. This study aims to elucidate these aspects, enhancing our understanding of NVP-BEZ235's future clinical utility. To investigate resistance mechanisms, cancer cell lines were exposed progressively increasing concentrations...