A5081764348- Aquaculture disease management and microbiota
- Viral Infectious Diseases and Gene Expression in Insects
- Aquaculture Nutrition and Growth
- Virus-based gene therapy research
- Glutathione Transferases and Polymorphisms
- Insect Resistance and Genetics
- Genomics and Phylogenetic Studies
- Protein Tyrosine Phosphatases
- Physiological and biochemical adaptations
- Biofuel production and bioconversion
- Tuberculosis Research and Epidemiology
- Plant-Microbe Interactions and Immunity
- Genomics, phytochemicals, and oxidative stress
- Mycorrhizal Fungi and Plant Interactions
- Pancreatic function and diabetes
- Galectins and Cancer Biology
- Molecular Biology Techniques and Applications
- Parasitic Infections and Diagnostics
- Genetics, Aging, and Longevity in Model Organisms
- Therapeutic Uses of Natural Elements
- Calcium signaling and nucleotide metabolism
- Hereditary Neurological Disorders
- Freezing and Crystallization Processes
- Viral gastroenteritis research and epidemiology
- FOXO transcription factor regulation
Guiyang Medical University
2018-2025
Henan University
2024
Peking University Cancer Hospital
2024
Shanxi University
2011-2024
Peking University
2024
Guangxi University
2012-2023
Beijing University of Civil Engineering and Architecture
2021
Chinese Academy of Fishery Sciences
2021
Huazhong Agricultural University
2021
Army Medical University
2020
The human genome, like other mammalian genomes, encodes numerous natural antisense transcripts (NATs) that have been classified into head-to-head, tail-to-tail, or fully overlapped categories in reference to their sense transcripts. Evidence for NAT-mediated epigenetic silencing of transcription remains scanty. DHRS4 gene a metabolic enzyme and forms cluster with its two immediately downstream homologous genes, DHRS4L2 DHRS4L1, generated by duplication. We identified head-to-head NAT DHRS4,...
Glutathione S-transferases (GSTs) play an important role in detoxification of xenobiotics both prokaryotic and eukaryotic cells. In this study, four GSTs (LmGSTd1, LmGSTs5, LmGSTt1, LmGSTu1) representing different classes were identified from the migratory locust, Locusta migratoria. These proteins heterologously expressed Escherichia coli as soluble fusion proteins, purified by Ni2+-nitrilotriacetic acid agarose column biochemically characterized. LmGSTd1, LmGSTu1 showed high activities...
Lysine benzoylation (Kbz) is a recently identified post-translational modification on histone that plays crucial role in regulating cellular processes. Current detection methods primarily rely mass spectrometry, which limits the ability to dynamically track lysine within living cells. Although azide/alkyne small-sized probes have enabled vitro labeling of various protein acylated modifications, their use dynamic tracking levels limited. Herein, we report novel 1-methylcyclopropene chemical...
2,4‐Dichlorophenol hydroxylase 2,4‐Dichlorophenoxyacetate plasmid degradation Alcaligenes eutrophus Pseudomonas putida
Glutathione S-transferase (GST) is a gene family generally associated with detoxification and plays an important role in detoxifying exogenous compounds. The silkworm Bombyx mori economic animal for silk production. However, it liable to infection by number of viruses chemical agents that can contaminate its food growing environment. Here we conducted comparative study strain- tissue-specific expressions GST the under infections nuclear polyhedrosis virus (BmNPV) densonucleosis (BmDNV)...
The Forkhead box transcription factors, Foxc1 and Foxc2, are crucial for development of the eye, cardiovascular network, other physiological systems, but their cell-type specific postdevelopmental functions unknown, in part because conventional (i.e., whole-organism) homozygous-null mutations either factor result perinatal death. Here, we describe generation mice with conditional-null Foxc1(flox) Foxc2(flox) that induced via Cre-mediated recombination. Mice homozygous unrecombined alleles...
Isoprenoid precursors, which are a large group of natural products and play key roles in many biological pathways, can only be biosynthesized by the 2-C-methyl-D-erythritol 4-phosphate pathway Mycobacterium tuberculosis. The 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE), is an essential enzyme isoprenoid precursor biosynthesis pathway, catalyzes ATP-dependent phosphorylation 4-diphospho-cytidyl-2-C-methyl-D-erythritol (CDP-ME) to...
A series of oleanolic acid (OA) derivatives have been synthesized and their inhibitory effects on PTP1B, TCPTP related PTPs are evaluated.Some compounds with five-membered heterocyclic ring-fused at C-2, C-3 positions showed a dramatic increase in inhibition, the two most potent PTP1B inhibitors 19 (IC 50 = 0.91 μM) 21 0.98 about 3-fold more than lead compound OA.Some C-ring modified OA analogs high selectivity for over TCPTP, among them, possessed best 6.6-fold.
Abstract Familial renal glycosuria (FRG) is caused by mutations in the SLC5A2 gene, which codes for Na + -glucose co-transporters 2 (SGLT2). The aim of this study was to analyze and identify 16 patients from 8 families with FRG. All coding regions, including intron-exon boundaries, were analyzed using PCR followed direct sequence analysis. Six gene identified, five missense (c.393G > C, p.K131N; c.1003A G, p.S335G; c.1343A p.Q448R; c.1420G p.A474P; c.1739G A, p.G580D) a 22-bp deletion...
Microsporidia are a large group of unicellular parasites that infect insects and mammals. The simpler life cycle microsporidia in provides model system for understanding their evolution molecular interactions with hosts. However, no complete genome is available insect-parasitic microsporidian species. Antonospora locustae , parasite obligately infects insects, reported here. size A. 3 170 203 nucleotides, composed 17 chromosomes onto which total 1857 annotated genes have been mapped...
Developing an efficient and safe strategy to introduce a therapeutic gene into targeting cells in vivo is key issue cancer therapy nowadays. Novel non-viral carriers, such as nanoparticles, have been shown be able deliver DNA efficiently. Suicide has demonstrated effective inhibiting tumor growth, however, the lack of specificity limits its application clinic. system for suicide attractive therapy. In this study, CMV enhancer carcinoembryonic antigen (CEA) promoter was fused chimeric...
Puerh tea, as the most representative Chinese dark has attracted global interest in recent years. Profiling levels of metal elements tea is very important since its presence related to human health. In this study, 41 98 samples from Yunnan province, China including raw and ripe were evaluated by microwave digestion combined with inductively coupled plasma mass spectrometry . The content toxic elements, essential rare earth different regions was discussed detail. concentrations Ba, Cr, As,...
This study investigated the effects of different dissolved oxygen (DO) levels on growth performance, antioxidant response and apoptosis juvenile GIFT (genetically improved farmed tilapia, Oreochromis niloticus). were fed with five DO (1, 2, 3, 4 5 mg/L) for 60 days, results showed that final body weight, weight gain rate, specific rate crude protein lipid contents fish muscle increased at mg/L DO. The activities digestive enzymes significantly up-regulated increasing levels. However,...
Excessive alcohol consumption has led to the prevalence of gastrointestinal ailments. Alleviating gastric disorders attributed alcohol-induced thinning mucus layer centered on enhancing mucin secretion as a pivotal approach. In this study, foxtail millet bran polyphenol BPIS was divided into two components with MW < 200 D and > by molecular interception technology. Combined MTT, cell morphology observation, trypan blue staining, isoferulic acid (IFA) within fraction determined...