A5004873786- Photoreceptor and optogenetics research
- Advanced Fluorescence Microscopy Techniques
- bioluminescence and chemiluminescence research
- Photosynthetic Processes and Mechanisms
- Cancer Genomics and Diagnostics
- Glycosylation and Glycoproteins Research
- Inhalation and Respiratory Drug Delivery
- Vibrio bacteria research studies
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- Galectins and Cancer Biology
- Advanced biosensing and bioanalysis techniques
- Photochemistry and Electron Transfer Studies
- Porphyrin and Phthalocyanine Chemistry
- Ubiquitin and proteasome pathways
- CAR-T cell therapy research
- Optical Imaging and Spectroscopy Techniques
- Epigenetics and DNA Methylation
- Photodynamic Therapy Research Studies
- RNA Interference and Gene Delivery
- Cystic Fibrosis Research Advances
- Nanowire Synthesis and Applications
- Immunotherapy and Immune Responses
Shanghai Jiao Tong University
2019-2025
Dartmouth College
2022
Jackson Laboratory
2021
Pennsylvania State University
2006-2009
Oncogenic extrachromosomal DNA elements (ecDNA) play an important role in tumor evolution, but our understanding of ecDNA biology is limited. We determined the distribution single-cell copy number across patient tissues and cell line models observed how cell-to-cell frequency varies greatly. The exceptional intratumoral heterogeneity suggested ecDNA-specific replication propagation mechanisms. To evaluate transfer genetic material from parental to offspring cells during mitosis, we...
The complex preparation procedures and severe toxicities are two major obstacles facing the wide use of chimeric antigen receptor-modified T (CAR-T) cells in clinical cancer immunotherapy. nanotechnology-based cell temporary CAR modification may be a potential approach to solve these problems make CAR-T cell-based tumor therapy feasible broadly applicable.A series plasmid DNA-loaded self-assembled nanoparticles (pDNA@SNPsx/y) prepared from adamantane-grafted polyamidoamine (Ad-PAMAM)...
Breast cancer (BC) is the most prevalent malignant tumor in women, with triple-negative breast (TNBC) showing poorest prognosis among all subtypes. Glycosylation increasingly recognized as a critical biomarker microenvironment, particularly BC. However, glycosylation-related genes associated TNBC have not yet been defined. Additionally, their characteristics and relationship deeply investigated. Transcriptomic analyses were used to identify signature (GRS) prognosis. A machine learning-based...
In the crowded cellular milieu, biological processes require coordinated intermolecular interactions, conformational changes, and molecular transport that span a wide range of spatial temporal scales. This complexity requires an integrated, noninvasive, multiscale experimental approach. Here, we develop multimodal fluorescence microspectroscopy system, integrated on single platform, to gain information about interactions their dynamics with high spatio-temporal resolution. To demonstrate...
Cystic fibrosis (CF) is a life-threatening, inherited, multi-organ disease that renders patients susceptible throughout their lives to chronic and ultimately deteriorating protracted pulmonary infections. Those infections are dominated in adulthood by the opportunistic pathogen, Pseudomonas aeruginosa (Pa). As with other advancing respiratory illnesses, people CF (pwCF) also frequently suffer from gastroesophageal reflux (GERD), including bile aspiration into lung. GERD major co-morbidity...
Two-photon autofluorescence dynamics imaging of metabolic co-factors, NADH and FAD, will be discussed as natural probes for cell biology. Of particular interest are the redox states energy metabolism in breast cancer normal cells.