A5100360271- Immune Response and Inflammation
- Organ Transplantation Techniques and Outcomes
- Neonatal Respiratory Health Research
- Inflammation biomarkers and pathways
- Light effects on plants
- Asthma and respiratory diseases
- Cell Adhesion Molecules Research
- Photosynthetic Processes and Mechanisms
- Plant Toxicity and Pharmacological Properties
- Plant Molecular Biology Research
- Vestibular and auditory disorders
- Stress Responses and Cortisol
- Atherosclerosis and Cardiovascular Diseases
- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Research Studies
- Liver Disease and Transplantation
- Phytochemistry and Bioactivity Studies
- Phytochemistry and Biological Activities
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Sepsis Diagnosis and Treatment
- Hearing, Cochlea, Tinnitus, Genetics
Jiangxi University of Traditional Chinese Medicine
2016-2024
Huashan Hospital
2021
Fudan University
2021
Wenzhou Medical University
2021
Inner Mongolia Medical University
2018
Jinshan Hospital of Fudan University
2017
East Tennessee State University
2015
Third Affiliated Hospital of Sun Yat-sen University
2012
Sun Yat-sen University
2012
Sepsis is a heterogeneous syndrome caused by dysregulated host response during the process of infection. Neutrophils are involved in development sepsis due to their essential role defense. COVID-19 viral sepsis. Disfunction neutrophils has been described previous studies, however, little known about microRNA-let-7b (miR-let-7b), toll-like receptor 4 (TLR4), and nuclear factor kappa B (NF-κB) activity how they participate In this study, we investigated regulatory pathway miR-let-7b/TLR4/NF-κB...
BACKGROUND The aim of this study was to investigate the effects TNF-α and IL-10 on expression ICAM-1 CD31 in human coronary artery endothelial cells (HCAEC). MATERIAL AND METHODS HCAEC treated with 0, 2.5 μg/l, 5 10 μg/l for 2 h, 6 0 100 200 h 15 respectively. RNA inference TNF-αR performed siRNA. Real-time PCR, Western blot analysis, ELSA were used detect mRNA level protein CD31. RESULTS significantly increased (P<0.05), had most obvious effect. RNAi TNF-aR reduced induction (P<0.05)....
Emerging evidence implied that chronic stress has been exerting detrimental impact on immune system functions in both humans and animals. Toll-like receptors (TLRs) have shown to play an essential role modulating responses cell survival. We recently TLR9 deficiency protects against lymphocyte apoptosis induced by stress. However, the exact of stress-mediated change macrophage function remains unclear. The results current study showed when BALB/c mice were treated with restraint (12 h daily...
Background: In recent years, the incidence of sudden deafness has gradually increased, with a very limited understanding its etiology and pathogenesis. Glucocorticoids are first choice treatment, but some hormone-resistant patients not sensitive to glucocorticoid therapy. The pathogenesis is yet known. this study, we aim construct HEI-OC1 cell line stably overexpressing Glucocorticoid Receptor Beta (GRβ), identify exact role in cases glucocorticoidresistant deafness. Methods: We used...
Objective To evaluate the radiosensitivity effect of CpG oligodeoxyribonucleotide (ODN) 7909 on human epidermoid cancer strain-2 (Hep-2) cells in vitro and discuss potential for improved radiotherapy treatment patients with laryngeal squamous cell carcinoma. Methods Toll-like receptor ( TLR) 9 expression was assessed Hep-2 using Western blots reverse transcription polymerase chain reaction. Cell Counting Kit-8 used to detect viability at 24 48 h following different ODN7909 concentrations....
The proliferation of airway smooth muscle cells (ASMCs) is a key feature remodeling in asthma. Azithromycin (AZM) has been shown to decrease bronchial hyperresponsiveness and inflammation asthmatics; however, the role AZM ASMC remains unclear. Thus, we investigated effect on rat model experimental asthma.We isolated ASMCs from rats sensitized challenged by ovabulmin (OVA), then treated with different concentrations AZM. Cytotoxicity was evaluated Cell Counting Kit-8 (CCK-8) assay,...
To investigate the chemical constituents from shoots of Chloranthus multistachys.All compounds wereisolated by using a combination various chromatographic techniques including silica gel, ODS, Sephadex LH-20, reversed-phase HPLC, and other methods.Their structures were elucidated nuclear magnetic resonance (NMR), mass spectrometry, modernspectroscopies.As result, 19 isolated C.multistachys identified as zederoneepoxide(1), chlomultin C(2), curcolonol(3), sarcaglaboside A(4), zedoarofuran(5),...