A5077894708- Spaceflight effects on biology
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Genomics and Phylogenetic Studies
- Space Exploration and Technology
- Planetary Science and Exploration
- Long-Term Effects of COVID-19
- Influenza Virus Research Studies
- Space Science and Extraterrestrial Life
- Respiratory viral infections research
- Bacteriophages and microbial interactions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- SARS-CoV-2 detection and testing
- Polar Research and Ecology
- Gut microbiota and health
- COVID-19 epidemiological studies
- Probiotics and Fermented Foods
- Bacterial Genetics and Biotechnology
- Inflammasome and immune disorders
- Antibiotic Resistance in Bacteria
- Protist diversity and phylogeny
- 14-3-3 protein interactions
- RNA and protein synthesis mechanisms
- Pneumonia and Respiratory Infections
Chinese PLA General Hospital
2013-2024
Yale University
2019-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2022
Capital Medical University
2020
Chinese People's Liberation Army
2020
Jinyintan Hospital
2020
Beijing Ditan Hospital
2020
Chinese People's Armed Police General Hospital
2014-2017
Chinese People's Armed Police Force
2014-2017
National Taiwan University Hospital
2013
The emergence of coronavirus disease 2019 (COVID-19) is a major healthcare threat. current method detection involves quantitative polymerase chain reaction (qPCR)-based technique, which identifies the viral nucleic acids when present in sufficient quantity. False-negative results can be achieved and failure to quarantine infected patient would setback containing transmission. We aim describe time kinetics various antibodies produced against novel (SARS-CoV-2) evaluate potential antibody...
This case series uses patient hospital data to summarize the clinical presentation and laboratory imaging findings of 13 patients with confirmed 2019-nCoV infection admitted hospitals in Beijing January 2020.
Triple-negative breast cancer (TNBC) relapses more frequently than hormone receptor-positive subtypes and is often associated with poor outcomes.This retrospective study reviewed the pattern of distant metastasis regard to survival in patients TNBC.A total 205 TNBC were analyzed.TNBC lung metastases had longest median post-metastatic OS (with 95% confidence interval) 16.6 (10.3-22.9)months, followed by bone, 16.3 (11.7-20.8)months, liver, 8.9 (3.5-14.4)months, pleura, 7.5 (2.8-12.3)months,...
COVID-19 pandemic has infected millions of people with mortality exceeding >1 million. There is an urgent need to find therapeutic agents that can help clear the virus prevent severe disease and death. Identifying effective safer drugs provide more options treat infections either alone or in combination. Here, we performed a high throughput screening approximately 1,700 US FDA-approved compounds identify novel effectively inhibit replication coronaviruses including SARS-CoV-2. Our two-step...
Abstract Coronavirus Disease 2019 (COVID-19) has caused a global pandemic. Here we profiled the humoral response against Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) by measuring immunoglobulin (Ig) A, IgM, and IgG nucleocapsid spike proteins, along with IgM antibodies receptor-binding domain (RBD) of protein total neutralizing (NAbs). We tested 279 plasma samples collected from 176 COVID-19 patients who presented enrolled at different stages their disease. Plasma dilutions were...
Cytokines are signaling molecules that play a role in myriad processes, including those occurring during diseases and homeostasis. Their homeostatic function begins embryogenesis persists throughout life, appropriate for the cell organism death. During viral infections, antiviral cytokines such as interferons inflammatory upregulated. Despite well-known benefits of these cytokines, their levels often correlate with disease severity, linking them to unfavorable outcomes. In this review, we...
BackgroundThe clinical management of coronavirus disease 2019 (COVID-19) is dependent on understanding the underlying factors that contribute to severity. In absence effective antiviral therapies, other host immunomodulatory therapies such as targeting inflammatory response are currently being used without clear evidence their effectiveness. Because inflammation an essential component mechanisms, may adversely affect viral clearance and outcome.ObjectiveTo understand whether persistent...
Increased cases of sepsis during COVID-19 in the absence known bacterial pathogens highlighted role viruses as causative agents sepsis. In this study, we investigated clinical, laboratory, proteomic, and metabolomic characteristics viral patients (
Occupational and environmental exposure to inorganic arsenic leads development of cancer represents a significant health hazard in more than 70 countries. The underlying mechanism for arsenic-induced carcinogenesis remains unclear. Laboratory studies suggest that is poor mutagen but may cause epigenetic silencing key tumor suppressor genes such as p16 through DNA hypermethylation. However, the evidence an association between human abnormal methylation lacking.Paired case-control were...
Background: Disease severity in COVID-19 ranges from asymptomatic infection to severe disease and death, especially older subjects. The risk for death has been reported be 2X those between 30 40 years, 3X 50 4X 65 compared the reference group of 18– 29 years. Objective: To investigate early changes host immune responses that are altered with age difference inflammatory response dictates a symptomatic versus course COVID-19. Patients Methods: subjects were identified by screening at airport...
The Hippo pathway plays a major role in development and organ size control, its dysregulation contributes to tumorigenesis. WWTR1 is transcription coactivator acting downstream of the pathway. Recently, has been reported be overexpressed several human cancers including lung cancer. However, molecular mechanism regulating cancer aggressiveness remains ambiguous. In present study, we analyzed expression NSCLC cell lines found that was at both mRNA protein levels. Knockdown by siRNA...
Seasonal influenza is a leading cause of disease worldwide, resulting in as many 650 000 deaths on yearly basis [1]. Vaccination the cornerstone prevention, but its efficacy limited by accuracy predicting circulating strains. Epidemiological methods such social distancing, use protective face masks and frequent hand washing are not routinely practiced prevention. In contrast, these have been widely applied during COVID-19 outbreak. this study, we investigated how year's season has impacted...
Abstract Postviral bacterial infections are a major health care challenge in coronavirus infections, including COVID-19; however, the coronavirus-specific mechanisms of increased host susceptibility to secondary remain unknown. In humans, coronaviruses, SARS-CoV-2, infect lung immune cells, alveolar macrophages, phenotype poorly replicated mouse models SARS-CoV-2. To overcome this, we used model native murine β-coronavirus that infects both and structural cells investigate...
With the development of space science, it is important to analyze relationship between environment and genome variations that might cause phenotypic changes in microbes. Klebsiella pneumoniae commonly found on human body resistant multiple drugs. To study space-environment-induced drug resistance changes, K. was carried into outer by Shenzhou VIII spacecraft. The strain LCT-KP289 selected after spaceflight based its differences compared ground-control strain. Analysis genomic structural...