A5042781462- Structural Load-Bearing Analysis
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Vibration and Dynamic Analysis
- Structural Engineering and Vibration Analysis
- Facial Trauma and Fracture Management
- Structural Engineering and Materials Analysis
- Spinal Fractures and Fixation Techniques
- Suicide and Self-Harm Studies
- Speech and Audio Processing
- Non-Destructive Testing Techniques
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Structural Response to Dynamic Loads
- Air Quality and Health Impacts
- Pain Mechanisms and Treatments
- Vacuum and Plasma Arcs
- Dental Anxiety and Anesthesia Techniques
- Multiple Sclerosis Research Studies
- Facial Nerve Paralysis Treatment and Research
- Dynamics and Control of Mechanical Systems
- Muscle Physiology and Disorders
- Transportation Safety and Impact Analysis
- Adaptive Control of Nonlinear Systems
Zhejiang University
2004-2024
Sir Run Run Shaw Hospital
2021-2022
Wuhan University
2011-2022
Harbin Institute of Technology
2022
Chongqing Jiaotong University
2013
China Communications Construction Company (China)
2013
Abstract The age-dependent decline in remyelination potential of the central nervous system during ageing is associated with a declined differentiation capacity oligodendrocyte progenitor cells (OPCs). molecular players that can enhance OPC or rejuvenate OPCs are unclear. Here we show that, mouse OPCs, nuclear entry SIRT2 impaired and NAD + levels reduced ageing. When supplement β-nicotinamide mononucleotide (β-NMN), an precursor, differentiation, were rescued aged animals. We effects on...
Abstract As a major neuron type in the brain, excitatory (EN) regulates lifespan C. elegans. How EN acquires senescence, however, is unknown. Here, we show that growth differentiation factor 11 (GDF11) predominantly expressed adult mouse, marmoset and human brain. In mice, selective knock-out of GDF11 post-mitotic shapes brain ageing-related transcriptional profile, induces senescence hyperexcitability, prunes their dendrites, impedes synaptic input, impairs object recognition memory...
Abstract Background Uncontrollable bleeding after tooth extraction usually occurs in patients with coagulation diseases, including hemophilia, von Willebrand’s disease, vitamin K deficiency, platelet and taking anticoagulant drugs. Hemophilia A is an X-linked recessive disorder caused by insufficiency of factor VIII. Mild defined level between 0.05 0.40 IU/mL, characterized uncontrollable hemorrhage trauma or invasive operations. Some mild hemophiliacs may remain undiagnosed until late...
Dynamic resistance measurement (DRM) was proved to be an important method for condition assessment of contact sets SF6 circuit breakers (CBs). The erosion due arc energy is a main factor that influences the electrical lifetime extinguishing chamber. In this study, high-voltage CB synthetic used produce fault current tests on sets. were close end their service life after series tests. DRMs with DC amperages 0.5, 1.0, and 1.5 kA conducted two tested in interval each test. Five essential...
Receptor interacting serine/threonine protein kinase 1 (RIPK1) activation and necroptosis have been genetically mechanistically linked with human multiple sclerosis neurodegenerative diseases for which demyelination is a common key pathology. Demyelination can be healed through remyelination mediated by new oligodendrocytes derived from the adult oligodendrocyte progenitor cells (OPCs). Unfortunately, efficiency of declines progressive aging partially due to depletion OPCs following chronic...
<p>Organoid technology, a notable advancement in biomedical engineering, has emerged over the past decade, offering significant scientific and therapeutic potential. By accurately mimicking structural functional intricacies of human organs at small scale, organoids have become groundbreaking tool for exploring basic biological principles, understanding disease mechanisms, progressing regenerative medicine. Despite large number relevant reports, comprehensive summary current organoid...
ER-phagy is an evolutionarily conserved mechanism crucial for maintaining cellular homeostasis. However, significant gaps persist in our understanding of how and the ER network vary across cell subtypes, tissues, organs. Furthermore, pathophysiological relevance remains poorly elucidated. Addressing these questions requires developing quantifiable methods to visualize architecture vivo. We generated two transgenic mouse lines expressing lumen-targeting tandem RFP-GFP (ER-TRG) tag, either...
Microglia dynamically monitor the microenvironment of central nervous system (CNS) by constantly extending and retracting their processes in physiological conditions, microglia/macrophages rapidly migrate into lesion sites response to injuries or diseases CNS. Consequently, migration ability is fundamentally important for proper functioning. However, mechanisms underlying have not been fully understood. We wonder whether voltage-gated proton channel HVCN1 brain plays a role migration. show...
A propagation model-based correction method for sound transmission loss error caused by hydrophone depth fluctuation is proposed. The motivation the to obtain laws of over range with in fixed depth. Firstly, we show that effect on shallow water environment significant through simulation at selected cases. Then, utilize acoustic model modify variation due water. At last, experimental data from ASIAEX processed, which shows feasible.
A disk Bézier curve is a whose control points are disks in plane. It can be viewed as parametric with error tolerances. In this paper, we discuss the problem of merging pair curves, that is, bounding two adjacent curves by single curve. We propose an efficient method to solve problem. The basic idea merge center original and take merged curve, then compute radius solving some optimization problems. Furthermore, it shown degree elevation will improve effect.
Based on structure principle of shear connector, a new type perfobond hoop has been proposed. The mechanical advantage PBH compared to traditional connector by analysis. According the measurement and reinforcement requirement suggested ECSS, finite element model established. important design parameters which have influence carrying capacity analyzed, such as concrete strength, hole numbers, bore diameter, bar diameter thickness steel plate with hole. Carrying calculation expression was put...
Abstract The mechanical models of Perfobond Hoop (PBH) and Leiste (PBL) shear connector were compared, based on their structure traits. PBH is more reasonable than PBL in mechanic. Then, the carrying capacities two forms connectors compared. It shows by experimental result that superior to capacity. model experiment specimen established using finite element method, then, FEM was verified comparing it with results. Furthermore, factors which may have influence capacity
Abstract Background Identifying spatiotemporal characteristics of daily fine particulate matter (PM 2.5 ) concentrations is essential for assessing air quality. Exposure analysis can help understand the environmental health impact on human beings and provide basic information appropriate decision making. This study aimed to estimate PM analyze resident exposure level in economically developed Yangtze River Delta (YRD) from 2016–2018. Methods An integrated method incorporating satellite-based...
Several studies have reported that individuals engaging in non-suicidal self-injury (NSSI), especially borderline personality disorder (BPD), feel no or little pain during acts of NSSI. While without comorbid mental disorders make the perception complex. Pain sensitivity, including threshold and tolerance, may be regarded as an indicator engagement NSSI, particularly NSSI-induced suicide. So, meta-analysis aimed to collect current evidence on sensitivity among NSSI identify correlation...