A5103226913- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Organ and Tissue Transplantation Research
- Transplantation: Methods and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Xenotransplantation and immune response
- Neonatal and Maternal Infections
- Cancer, Lipids, and Metabolism
- Liver physiology and pathology
- Ovarian cancer diagnosis and treatment
- Autophagy in Disease and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Boron Compounds in Chemistry
- Magnesium in Health and Disease
- Potassium and Related Disorders
- Airway Management and Intubation Techniques
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Colorectal Cancer Surgical Treatments
- Tracheal and airway disorders
- Testicular diseases and treatments
- Neurological Complications and Syndromes
- Cancer therapeutics and mechanisms
- Streptococcal Infections and Treatments
- Urinary and Genital Oncology Studies
Zhejiang University
2012-2025
Second Affiliated Hospital of Zhejiang University
2012-2025
Zhengzhou Children's Hospital
2023
Zhengzhou University
2023
Zhejiang Chinese Medical University
2019
Charité - Universitätsmedizin Berlin
2013
Beth Israel Deaconess Medical Center
2012
Harvard University
2012
Introduction: Sepsis is the most severe infectious disease with highest mortality rate, particularly among neonates admitted to neonatal intensive care unit (NICU). This study retrospectively analyzed epidemiology, antibiotic resistance profiles, and prevalence of multidrug-resistant (MDR) bacteria isolated from blood or cerebrospinal fluid (CSF) cultures in order evaluate appropriateness initial empirical therapy for sepsis. Methods: A retrospective was conducted NICU January 1, 2015,...
Gastric cancer (GC) is a common malignancy of the digestive system. According to global 2018 data, GC has fifth-highest incidence and third-highest fatality rate among malignant tumors. More than 60% are linked infection with
Background Alpha-fetoprotein-producing gastric cancer (AFPGC) is a highly malignant subtype of cancer, but solely alpha-fetoprotein may fail to accurately predict the prognosis. Although utilization multi tumor markers could improve stratified patient management, such research in AFPGC still blank. This study seeks evaluate whether combining multiple can enhance risk stratification and identify subtypes with poor Methods We first screened for patients elevated serum CEA levels within cohort...
Abstract Hepatocellular carcinoma (HCC) still ranks among the top cancers worldwide with high incidence and mortality. Due to abnormal activation of PI3K/AKT/mTOR signalling pathway in HCC, targeting this represents a potential therapeutic strategy. NVP-BEZ235 is novel dual-targeted ATP-competitive PI3K/mTOR inhibitor that has shown effective antitumor effects. In study, we found interleukin-6 (IL-6) was significantly increased after exposure NVP-BEZ235, proposed treatment which an anti-IL-6...
Background. Graft rejection continues to be a major barrier long-term engraftment after transplantation. Autophagy plays an important role in cardiac injury pathogenesis. The bromodomain and extraterminal protein inhibitor (S)-tert-butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate (JQ1) inhibits inflammatory responses. However, the beneficial effect of JQ1 on transplant potential autophagy protective graft survival are yet...
To study the killing effects on osteosarcoma cells of cinobufacini and cisplatin in combination related mechanisms so as to explore chemotherapeutic method with integrated traditional Chinese Western medicines.Cinobufacini were applied OS732 singly or jointly survival rates measured by MTT assay. Changes cellular shape observed inverted phase contrast fluorescence microscopy apoptosis analyzed flow cytometry (FCM). Immunocytochemistry used examine Fas expression cells.The had effect...
The murine cervical heterotopic heart transplant model was initially designed to test the immune response third-party allografts, modified by cuff techniques. While techniques simplify execution of this procedure, cutting carotid artery and external jugular vein alters blood supply central nervous system makes it difficult achieve long-term graft survival. In present study, we describe that preserve continuity function vessels improve integrity.The in study comprise following aspects: (1)...
ER-phagy is an evolutionarily conserved mechanism crucial for maintaining cellular homeostasis. However, significant gaps persist in our understanding of how and the ER network vary across cell subtypes, tissues, organs. Furthermore, pathophysiological relevance remains poorly elucidated. Addressing these questions requires developing quantifiable methods to visualize architecture vivo. We generated two transgenic mouse lines expressing lumen-targeting tandem RFP-GFP (ER-TRG) tag, either...
BACKGROUND This study aimed to determine whether patterns of tumor clonal origin in pluri-nodular hepatocellular carcinoma (PNHC) could serve as an indicator recurrence following liver transplantation. MATERIAL AND METHODS Tumor tissue samples from 60 PNHC patients who underwent transplantation were examined. The diagnosis conformed the University California San Francisco (UCSF) standards for carcinoma. We performed loss heterozygosity tests at multiple microsatellite sites origins tumors....
Alpha-fetoprotein (AFP)-producing gastric cancer is a relatively rare form of stomach malignancy. Patients with higher serum AFP level (>300 ng/mL) will have poorer prognosis. In this study, we present case 77-year-old woman an extremely high expression (>10,000 cancer. Histological examination revealed adenocarcinoma (Bormann III tumor) invading into the serosal layer and vessel. After receiving successful total gastrectomy D2 dissection, patient underwent chemotherapy SOX [oxaliplatin (130...
Abstract Objectives IL-6 is an inflammatory marker and urea nitrogen (UREA) a common indicator of glomerular filtration function. Their combined detection has predictive value for the severity neonatal pneumonia. Methods We performed cross-sectional analysis clinical laboratory data, collected from 105 patients (including 76 mild to moderate pneumonia 29 severe patients). Results Mann–Whitney U-test showed serum UREA levels were significantly increased in pneumonia, compared with that...