A5102752241- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Neurological Complications and Syndromes
- Cytomegalovirus and herpesvirus research
- RNA modifications and cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Ferroptosis and cancer prognosis
- Nutrition and Health in Aging
- FOXO transcription factor regulation
- Urinary Tract Infections Management
- Material Dynamics and Properties
- PI3K/AKT/mTOR signaling in cancer
- Hippo pathway signaling and YAP/TAZ
- ZnO doping and properties
- Antibiotic Resistance in Bacteria
- Electronic and Structural Properties of Oxides
- HIV-related health complications and treatments
- Proteins in Food Systems
- Peptidase Inhibition and Analysis
- Hepatitis B Virus Studies
Qingdao University
2021-2025
Affiliated Hospital of Qingdao University
2021-2025
Union Hospital
2022-2024
Fujian Medical University
2022-2024
Tianjin Medical University
2021
Tianjin People's Hospital
2021
Tianjin First Center Hospital
2021
Background: Due to the heterogeneity of tumors and complexity immune microenvironment, specific role ferroptosis pyroptosis in hepatocellular carcinoma (HCC) is not fully understood, especially its impact on prognosis. Methods: The training set (n = 609, merged by TCGA GSE14520) was clustered into three subtypes (C1, C2, C3) based prognosis-related genes associated with pyroptosis. intersecting differentially expressed (DEGs) among C1, C3 were used univariate Cox LASSO penalized regression...
Abstract Background and aims Due to a lack of donor grafts, steatotic livers are used more often for liver transplantation (LT). However, sensitive ischemia–reperfusion (IR) injury have worse prognosis after LT. Efforts optimize grafts by identifying targets interventions become hot issue. Methods Mouse LT models were established, 4D label-free proteome sequencing was performed four groups: normal control (NC) SHAM, high-fat (HF) NC LT, HF screen molecular aggravating in Expression detection...
Sarcopenia is associated with unfavourable long-term survival in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). However, the impact of myosteatosis and muscle loss on patient prognosis has not been investigated.
Abstract Hepatocellular carcinoma (HCC) still ranks among the top cancers worldwide with high incidence and mortality. Due to abnormal activation of PI3K/AKT/mTOR signalling pathway in HCC, targeting this represents a potential therapeutic strategy. NVP-BEZ235 is novel dual-targeted ATP-competitive PI3K/mTOR inhibitor that has shown effective antitumor effects. In study, we found interleukin-6 (IL-6) was significantly increased after exposure NVP-BEZ235, proposed treatment which an anti-IL-6...
Background: Split liver transplantation increases graft availability, but its safe and effective utilization is insufficiently documented. This study aimed to investigate the association between perioperative body composition abnormalities outcomes in adult split transplantation. Materials Methods: 240 recipients who underwent three centers were enrolled this retrospective cohort study. Body including sarcopenia, myosteatosis, visceral obesity, sarcopenic obesity evaluated at baseline one...
Numerous studies have discussed the impact of cosolvents on structure, dynamics, and stability proteins in aqueous solutions. However, dynamics protein-water-cosolvent ternary system is largely unexplored experiments due to technical difficulty. Consequently, a comprehensive understanding interplay among proteins, water, still lacking. Here, we employed selective deuteration neutron scattering techniques characterize individual motions each component protein/water/glycerol (GLY) mixture...
Objective: Sex-specific differences are observed in various liver diseases, but the influence of sex on outcomes hepatocellular carcinoma (HCC) after transplantation (LT) remains to be determined. This study is first Chinese nationwide investigation role post-LT patients with HCC. Methods: Data for recipients HCC registered China Liver Transplant Registry between January 2015 and December 2020 were analyzed. The associations donor, recipient, or donor-recipient transplant patterns by studied...
Abstract Sirolimus is a regularly applied immunosuppressant for patients undergoing liver transplantation (LT) hepatocellular carcinoma (HCC). not only significantly inhibits HCC recurrence but also protects renal function. However, the improvement effect of sirolimus on nontumour-related death in still unknown. The aim our study was to investigate therapeutic deaths. In this study, we retrospectively enrolled 403 LT with from January 1, 2015, December 31, 2018. median follow-up time 47.1...
A high model of end-stage liver disease (MELD) score (>30) adversely affects outcomes even if patients receive prompt transplantation (LT). Therefore, balanced allocation donor grafts is indispensable to avoid random combinations and recipient risk factors, which often lead graft or loss. Predictive models aimed at avoiding factors in high-MELD recipients are urgently required obtain satisfactory outcomes.Data with MELD >30 who underwent LT three institutes between 2015 2018 were...
This study aimed to investigate the colonization and prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in pediatric liver transplant recipients analyze high-risk factors prognosis CRE infection.A prospective involving 152 patients undergoing transplantation was carried out. Anal swab bacteria cultures were collected when entered intensive care unit (ICU) they left order screen for intestinal colonization. The results grouped according occurrence infection following surgery, divided...
Primary neuroendocrine tumors of the gallbladder (GB-NETs) are rare, accounting for 2% all cancers. Among GB-NETs, mixed non-neuroendocrine neoplasms (GB-MiNENs) sporadic.A 56-year-old woman admitted to our hospital due right upper abdominal pain 3 days duration. She underwent positron emission tomography/computed tomography, which showed multiple metastatic and was unsuitable operation. Initially, patient diagnosed with adenocarcinoma. PD-1 inhibitor or combined chemotherapy considering...
Background and aims: The practice of intraoperative blood salvage autotransfusion (IBSA) during deceased donor liver transplantation for hepatocellular carcinoma (HCC) can potentially reduce the need allogeneic transfusion. However, implementing IBSA remains debatable due to concerns about its possible detrimental effects on oncologic recurrence. Methods: This study retrospectively enrolled nationwide recipients HCC between 2015 2020. focus was comparing cumulative recurrence rate...
To explore the related factors of vascular complications after liver transplantation in children.
Abstract Background Regorafenib is an oral multikinase inhibitor and became the first second-line systemic treatment for hepatocellular carcinoma (HCC) following phase III RESORCE trial. This single-center study retrospectively analyzed clinical data follow-up results of patients with recurrent HCC treated regorafenib discussed prognostic factors to provide guidance treatment. Methods Ninety-three were enrolled in research follow up from December 2017 2020. Clinical pathological collected....