A5100408181- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Cancer Immunotherapy and Biomarkers
- COVID-19 and healthcare impacts
- Multiple Myeloma Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Fungal Biology and Applications
- CAR-T cell therapy research
- Intensive Care Unit Cognitive Disorders
- Neuropeptides and Animal Physiology
- Folate and B Vitamins Research
- Immunotherapy and Immune Responses
- Biocrusts and Microbial Ecology
- Protein Degradation and Inhibitors
- Plant and Biological Electrophysiology Studies
- Bone health and treatments
- Pregnancy and preeclampsia studies
- Colorectal and Anal Carcinomas
- Bladder and Urothelial Cancer Treatments
- Renal Transplantation Outcomes and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Epigenetics and DNA Methylation
Icahn School of Medicine at Mount Sinai
2020-2022
People's Liberation Army No. 150 Hospital
2022
Chinese People's Liberation Army
2022
PLA Academy of Military Science
2022
Hainan Medical University
2022
Hainan General Hospital
2022
Sichuan University
2021
State Key Laboratory of Biotherapy
2021
GlaxoSmithKline (Italy)
2021
Hangzhou First People's Hospital
2021
Abstract Background The COVID-19 pandemic, caused by SARS-CoV-2 virus, has resulted in over 100,000 deaths the USA. Our institution treated 2000 patients during pandemic New York City. directly impacted cancer and organization of care. Mount Sinai Hospital a large diverse multiple myeloma (MM) population. Herein, we report characteristics infection serological response MM tertiary care York. Methods We performed retrospective study on cohort 58 with plasma-cell disorder (54 MM, 4 smoldering...
The COVID-19 pandemic caused by infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to more than 100,000 deaths in the United States. Several studies have revealed that hyper-inflammatory response induced SARS-CoV-2 is a major cause of disease severity and death infected patients. However, predictive biomarkers pathogenic inflammation help guide targetable immune pathways are critically lacking. We implemented rapid multiplex cytokine assay measure serum IL-6,...
Pancreatic ductal adenocarcinoma is one of the leading causes cancer-related death worldwide. Immune checkpoint blockade therapy, including anti-PD-1 and anti-PD-L1, a new therapeutic strategy for cancer treatment but monotherapy with PD-L1 inhibitors pancreatic almost ineffective cancer. Thus, exploring regulatory mechanism in cells, especially key strategies to improving patient response therapy. Histone acetyltransferase 1(HAT1) classic type B histone biological role HAT1 unclear.The...
The mortality rate of elderly patients with Coronavirus Disease 2019 (COVID-19) was significantly higher than the overall rate. However, besides age, leading death risk factors for high in remain unidentified. This retrospective study included 210 COVID-19 (aged ≥ 65 years), whom 175 were discharged and 35 died. All deceased had at least one comorbidity. A proportion group cardiovascular diseases (49% vs. 20%), respiratory (51% 11%), chronic kidney disease (29% 5%) cerebrovascular (20% 3%)...
Abstract Background Patients with malignancy are particularly vulnerable to infection Severe Acute Respiratory Disease‐Coronavirus‐2 (SARS‐CoV‐2) given their immunodeficiency secondary underlying disease and cancer‐directed therapy. We report a case series of patients cancer who received convalescent plasma, an investigational therapy for severe Coronavirus Disease 2019 (COVID‐19). Methods were identified plasma. Enrolled had confirmed COVID‐19 or life‐threatening transfused plasma from...
The main aspects of severe COVID-19 disease pathogenesis include hyper-induction proinflammatory cytokines, also known as 'cytokine storm', that precedes acute respiratory distress syndrome (ARDS) and often leads to death. patients suffer from lung fibrosis, a serious untreatable condition. There remains no effective treatment for these complications. Out all TNFα IL-6 play crucial roles in cytokine storm are likely responsible the escalation severity. These cytokines partake molecular...
With the progresses in medical development recent years, plasma homocysteine (Hcy) levels are considered to be an independent risk factor for of coronary heart disease (CHD). We hope use method meta-analysis systematically evaluate relationship between Hcy and CHD, providing a basis prevention, diagnosis treatment CHD.The PubMed, Cochrane Embase databases were searched case-control studies cohort on association CHD from database establishment October 2021. Duplicate re-excluded by Endnote X9...
The COVID-19 pandemic, caused by SARS-CoV-2 virus, has resulted in over 100,000 deaths the United States. Our institution treated 2,000 patients during pandemic New York City. directly impacted cancer and organization of care. Mount Sinai Hospital a large diverse multiple myeloma (MM) population. Herein, we report characteristics infection serological response MM tertiary care York. We performed retrospective study on cohort 58 with plasma-cell disorder (54 MM, 4 smoldering MM) who developed...
Abstract During the COVID-19 outbreak, mobile cabin hospital has effectively isolated and treated patients diagnosed as mild-moderate disease. However, a detailed clinical course not been well described. We included 483 who were from Feb 6, 2020, to 15, including definite outcome (discharge or deterioration). Sixty-two transferred severe cases, of whom trasfered designated for intensive care. By March 9, all discharged without dead. The provides feasible strategy isolation cases timely...
During the COVID-19 pandemic, a phenomenon emerged in which some patients with severe disease were critically ill and could not be discharged from ICU even though they exhibited negative viral tests. To explore underlying mechanism, we collected blood samples these analyzed gene expression profiles of peripheral immune cells. We found that all enrolled patients, regardless changes genes related to different symptoms inflammatory responses, showed universally severely decreased adaptive...
Response to immune checkpoint inhibitor (ICI) remains limited a subset of patients and predictive biomarkers response an unmet need, limiting our ability provide precision medicine. Using real-world data, we aimed identify potential clinical prognosticators ICI in solid tumor patients.We conducted retrospective analysis all treated with ICIs at the Mount Sinai Hospital between January 2011 April 2017. Predictors assessed included demographics, performance status, co-morbidities, family...
The outbreak of coronavirus disease 2019 (COVID-19) has become a world-wide emergency. severity COVID-19 is highly correlated with its mortality rate. We aimed to disclose the clinical characteristics and prognostic factors patients who developed severe COVID-19. study enrolled cases (no=1848) mild or moderate type in Fangcang shelter hospital Jianghan. A total 56 progressed from severe. used least absolute shrinkage selection operator regression model select for this model. case-severity...
Summary Background The outbreak of coronavirus disease 2019 (COVID-19) has become a world-wide emergency. Fangcang shelter hospitals have been applied in COVID-19 to ease ongoing shortage medical resources Wuhan since February 2020. Method This study enrolled all cases (no=1848) with mild or moderate type hospital Jianghan from Feb 5th Mar 9th, Diagnosis was based on the National health commission China. Epidemiological history, comorbidity, vital signs, symptoms and signs were recorded...
e15160 Background: Development (DV) of immune-related adverse events (IRAEs) to immune checkpoint inhibitor (ICI) have been associated (asso/) with (w/) favorable treatment (tx) response, but heterogeneity in clinical presentation remains a concern. We aim characterize the type, timing, and risk factors asso/ w/ IRAE DV ICI-treated solid tumor (ST) patients (pts). Methods: The characteristics (char), tx course, outcomes ST pts who received at least 2 ICI doses our institution from 1/1/2011...
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been spreading globally. Information regarding the characteristics and prognosis of antibody non-responders to COVID-19 is limited.In this retrospective, single-center study, we included all patients with confirmed using real-time reverse transcriptase-polymerase chain reaction (RT-PCR) admitted Fire God Mountain hospital from February 3, 2020, April 14, 2020. A total 1,921 were...
SUMMARY Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are highly effective in healthy individuals. Patients with multiple myeloma (MM) immunocompromised due to defects humoral and cellular immunity as well immunosuppressive therapies. The efficacy after two doses of SARS-CoV-2 mRNA vaccination MM patients is currently unknown. Here, we report the case a patient who developed fatal infection full while remission B cell maturation antigen (BCMA)-targeted chimeric...
To evaluate the effect of teriparatide on life quality in patients with postmenopausal osteoporosis.
Immunohistochemistry (IHC) is one of the most important adjunctive techniques in surgical pathology. Quality controls are essential for staining interpretation. The common cut from formalin-fixed, paraffin-embedded tissue blocks advance. In contrast, we developed fragment suspension (PETFS), a novel method liquid form, quality control preparation. form were donor paraffin blocks, stored 4°C fridge easily, and added to top bottom test slide directly by pipetting. fragments PETFS had...