A5015793767- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Effects of Radiation Exposure
- DNA Repair Mechanisms
- Cannabis and Cannabinoid Research
- RNA modifications and cancer
- Plant Genetic and Mutation Studies
- Cancer-related molecular mechanisms research
- Radiation Therapy and Dosimetry
- Circular RNAs in diseases
- Childhood Cancer Survivors' Quality of Life
- RNA Research and Splicing
- Carcinogens and Genotoxicity Assessment
- Terahertz technology and applications
- Genetically Modified Organisms Research
- Genomics and Chromatin Dynamics
- Tryptophan and brain disorders
- Cancer-related cognitive impairment studies
- Pancreatic function and diabetes
- Dietary Effects on Health
- Psychedelics and Drug Studies
- Gene expression and cancer classification
- Microbial Inactivation Methods
- Stress Responses and Cortisol
- GABA and Rice Research
University of Lethbridge
2016-2025
Belgorod National Research University
2020-2025
Vinnytsia Mykhailo Kotsiubynskyi State Pedagogical University
2022
National University of Kyiv Mohyla Academy
2021
Moscow State Pedagogical University
2019-2020
Vladivostok State University
2019
Institute of Biophysics
2017
Chinese Academy of Sciences
2017
Alberta Children's Hospital
2014
University of Calgary
2014
Abstract Many chemotherapy regiments are successfully used to treat breast cancer; however, often cancer cells develop drug resistance that usually leads a relapse and worsening of prognosis. We have shown recently epigenetic changes such as DNA methylation histone modifications play an important role in cell chemotherapeutic agents. Another mechanism gene expression control is mediated via the function small regulatory RNA, particularly microRNA (miRNA); its still remains unexplored. In...
Micronuclei (MN) are extra-nuclear bodies that contain damaged chromosome fragments and/or whole chromosomes were not incorporated into the nucleus after cell division. MN can be induced by defects in repair machinery and accumulation of DNA damages chromosomal aberrations. A variety genotoxic agents may induce formation leading to death, genomic instability, or cancer development. In this review, genetic epigenetic mechanisms various clastogenic aneugenic effects on division cycle...
Cancer cells that develop resistance to chemotherapeutic agents are a major clinical obstacle in the successful treatment of breast cancer. Acquired cancer chemoresistance is multifactorial phenomenon, involving various mechanisms and processes. Recent studies suggest may be linked drug-induced dysregulation microRNA function. Furthermore, mounting evidence indicates existence similarities between drug-resistant metastatic terms apoptosis enhanced invasiveness. We studied role miRNA...
Particulate air pollution is widespread, yet we have little understanding of the long-term health implications associated with exposure. We investigated DNA damage, mutation, and methylation in gametes male mice exposed to particulate an industrial/urban environment. C57BL/CBA were situ ambient near two integrated steel mills a major highway, alongside control breathing high-efficiency (HEPA) filtered air. PCR analysis expanded simple tandem repeat (ESTR) locus revealed 1.6-fold increase...
Accurate and physiologically meaningful biomarkers for human aging are key to assessing antiaging therapies. Given ethnic differences in health, diet, lifestyle, behavior, environmental exposures, even average rate of biological aging, it stands reason that clocks trained on datasets obtained from specific populations more likely account these potential confounding factors, resulting an enhanced capacity predict chronological age quantify age. Here, we present a deep learning-based...
Abstract The “radiation-induced bystander effect,” in which irradiated cells can induce genomic instability unirradiated neighboring cells, has important implications for cancer radiotherapy and diagnostic radiology as well human health general. Although the mechanisms of this effect remain to be elucidated, we reported previously that DNA double-strand breaks (DSBs), directly measured by γ-H2AX focus formation assay, are induced cultured cells. To overcome deficiencies cell studies,...
The gestational state is a period of particular vulnerability to diseases that affect maternal and fetal health. Stress during gestation may represent powerful influence on mental health offspring brain plasticity development. Here we show the transcriptome, through microRNA (miRNA) regulation, responds prenatal stress in association with epigenetic signatures psychiatric neurological diseases. Pregnant Long-Evans rats were assigned from days 12 18 while others served as handled controls....
Radiation therapy is a primary treatment modality for brain tumors, yet it has been linked to the increased incidence of secondary, post-radiation cancers. These cancers are thought be indirect radiation-induced bystander effect. Bystander effect occurs when irradiated cells communicate damage nearby, non-irradiated 'bystander' cells, ultimately contributing genome destabilization in non-exposed cells. Recent evidence suggests that may epigenetic nature; however, characterization mechanisms...
Abstract With each passing year since the Chernobyl accident of 1986, more questions arise about potential for organisms to adapt radiation exposure. Often this is thought be attributed somatic and germline mutation rates in various organisms. We analyzed adaptability native Arabidopsis plants collected from areas with different levels contamination around nuclear power plant 1986 1992. Notably, progeny resisted higher concentrations mutagens Rose Bengal methyl methane sulfonate. possible...
Recent emergence and growing use of terahertz (THz) radiation for medical imaging public security screening raise questions on reasonable levels exposure health consequences this form electromagnetic radiation.In particular, picosecond-duration THz pulses have shown promise novel diagnostic techniques.However, the effects human cells tissues thus far remain largely unknown.We report investigation biological pulsed artificial skin tissues.We observe that to intense ten minutes leads a...
Chronic stress is considered to be one of many causes human preterm birth (PTB), but no direct evidence has yet been provided. Here we show in rats that across generations downstream effects on endocrine, metabolic and behavioural manifestations PTB possibly via microRNA (miRNA) regulation. Pregnant dams the parental generation were exposed from gestational days 12 18. Their pregnant daughters (F1) grand-daughters (F2) either stressed or remained as non-stressed controls. Gestational length,...
Terahertz (THz) radiation lies between the infrared and microwave regions of electromagnetic spectrum is non-ionizing. We show that exposure artificial human skin tissue to intense, picosecond-duration THz pulses affects expression levels numerous genes associated with non-melanoma cancers, psoriasis atopic dermatitis. Genes affected by intense include nearly half epidermal differentiation complex (EDC) members. EDC genes, which are mapped chromosomal region 1q21, encode for proteins partake...
There is an association between smoking and cancer, cardiovascular disease all-cause mortality. However, currently, there are no affordable informative tests for assessing the effects of on rate biological aging. In this study we demonstrate first time that status can be predicted using blood biochemistry cell count results andthe recent advances in artificial intelligence (AI). By employing age-prediction models developed supervised deep learning techniques, found smokers exhibited higher...
With the current COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is an urgent need for new therapies and prevention strategies that can help curtail disease spread reduce mortality. The inhibition of viral entry thus a plausible therapeutic avenue. SARS-CoV-2 uses receptor-mediated into human host via angiotensin-converting enzyme (ACE2), which expressed in lung tissue as well oral nasal mucosa, kidney, testes gastrointestinal tract....
Piwi-interacting RNAs (piRNAs), whose role in germline maintenance has been established, are now also being classified as post-transcriptional regulators of gene expression somatic cells. PIWI proteins, central to piRNA biogenesis, have identified genetic and epigenetic expression. piRNAs/PIWIs emerged potential biomarkers for cancer but their relevance breast not comprehensively studied. piRNAs mRNAs were profiled from normal tumor tissues using next generation sequencing Agilent platforms,...