A5025657041- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Renal Transplantation Outcomes and Treatments
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Mesenchymal stem cell research
- Transplantation: Methods and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- Cancer, Hypoxia, and Metabolism
- Cytomegalovirus and herpesvirus research
- Organ Donation and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Chemokine receptors and signaling
- Phagocytosis and Immune Regulation
- Immune Response and Inflammation
- Pregnancy and Medication Impact
- Organ and Tissue Transplantation Research
- Liver Diseases and Immunity
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
Zhejiang University
2010-2024
Blood Center of Zhejiang Province
2017-2024
First Affiliated Hospital Zhejiang University
2012-2024
Hangzhou Red Cross Hospital
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Eastern Hepatobiliary Surgery Hospital
2017
Second Military Medical University
2017
Ministry of Public Health
2017
Center for Innovation
2017
Chengdu Military General Hospital
2015
TLR4 (Toll-like receptor 4) and B7-H1, which were known to be restricted immune cells in the past, found aberrantly expressed a majority of tumor cells, facilitating evasion from surveillance. Our study demonstrated that activation signaling bladder cancer up-regulated B7-H1 expression. Furthermore, this regulation was significantly attenuated by ERK or JNK inhibitor. results elucidated molecule mechanism expression through may suggest new strategies down-regulating cancer-associated for treatment.
Abstract Recent studies suggest that circular RNA (circRNA)‐mediated post‐translational modification of RNA‐binding proteins (RBP) plays a pivotal role in metastasis hepatocellular carcinoma (HCC). However, the specific mechanism and potential clinical therapeutic significance remain vague. This study attempts to profile regulatory networks circRNA RBP using multi‐omics approach. Has_circ_0006646 (circ0006646) is an unreported HCC associated with poor prognosis. Silencing circ0006646...
Abstract Background/Aims New‐onset diabetes after transplantation ( NODAT ) is a serious complication of liver LT ). The present study aimed to investigate the risk factors by national survey using China Liver Transplant Registry database. Patients A total 10 204 non–pre‐existing diabetic patients undergone primary between January 2000 and December 2013 were included. Risk identified logistic regression analysis. Results occurred in 24.3% recipients with median follow‐up time 2.6 years, was...
Abstract Background Treatment guidelines for a variety of cancers have been increasingly used in clinical practice, and resulted major improvement patient outcomes. However, recommended regimens (even first‐line treatments) are clearly not ideal every patients. In the present study, we mini patient‐derived xenograft (mini‐PDX) next‐generation sequencing to develop personalized treatment with metastatic duodenal adenocarcinoma. Methods Resected metachronous tumor tissues were implanted into...
Although stem cell therapy holds promise as a potential treatment in number of diseases, the tumorigenicity embryonic cells (ESC) and induced pluripotent remains major obstacle. In vitro predifferentiation ESCs can help prevent risk teratoma formation, yet proliferating neural progenitors generate tumors, especially presence immunosuppressive therapy. this study, we investigated effects microenvironment on growth development using undifferentiated ESCs. Syngeneic ESC transplantation...
Lung metastasis is a common and fatal complication of liver transplantation for hepatocellular carcinoma (HCC). The precise prediction post-transplant lung in the early phase great value.The mRNA profiles primary paired metastatic lesions were analyzed to determine key signaling pathways. We enrolled 241 HCC patients who underwent from three centers. Tissue microarrays used evaluate prognostic capacity tumor necrosis factor (TNF), receptor 1 (TNFR1), TNFR2, particularly metastasis.Comparison...
Specific tumor-targeted gene delivery remains an unsolved therapeutic issue due to aberrant vascularization in tumor microenvironment (TME). Some bacteria exhibit spontaneous chemotaxis toward the anaerobic and immune-suppressive TME, which makes them ideal natural vehicles for cancer therapy. Here, we conjugated ZIF-8 metal-organic frameworks encapsulating eukaryotic murine interleukin 2 (Il2) expression plasmid onto surface of VNP20009, attenuated Salmonella typhimurium strain with...
AIM:To investigate the possible protective effects of carnosol on liver injury induced by intestinal ischemia reperfusion (I/R). METHODS:Rats were divided randomly into three experimental groups: sham, I/R and treatment (n = 18 each).The model was established clamping superior mesenteric artery for 1 h.In group, surgery performed as in with intraperitoneal administration 3 mg/kg h before operation.At 2, 4 6 after reperfusion, rats killed blood, intestine tissue samples obtained.Intestine...
CONCLUSION:The activation of NF-κB plays an important role in the pathogenesis lung injury induced by intestinal I/R through upregulating neutrophil infiltration and ICAM-1 expression.PDTC as inhibitor can prevent inhibiting activity NF-κB.
The transplantation of endothelial progenitor cells (EPCs) provides a novel method for the treatment human tumors or vascular diseases. Magnetic resonance imaging (MRI) has proven to be effective in tracking transplanted stem by labeling with superparamagnetic iron oxide (SPIO) nanoparticles. SPIO been used label and track EPCs; however, effect upon EPCs remains unclear on cellular level. In present study, were labeled home-synthesized nanoparticles vitro biological characteristics...