A5101399674- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Cardiac Valve Diseases and Treatments
- Synthesis and Catalytic Reactions
- Metal complexes synthesis and properties
- Pancreatic function and diabetes
- Metal-Organic Frameworks: Synthesis and Applications
- Crystal structures of chemical compounds
- Liver physiology and pathology
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Protein Degradation and Inhibitors
- Adipose Tissue and Metabolism
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Cardiac and Coronary Surgery Techniques
- RNA Interference and Gene Delivery
- Aortic aneurysm repair treatments
- Hippo pathway signaling and YAP/TAZ
- Advanced biosensing and bioanalysis techniques
- Sulfur-Based Synthesis Techniques
- Cytomegalovirus and herpesvirus research
- Cardiovascular Health and Risk Factors
- Mechanisms of cancer metastasis
Zhejiang Hospital
2019-2025
Union Hospital
2016-2024
Huazhong University of Science and Technology
2016-2024
Nanjing Normal University
2022
Second Affiliated Hospital of Zhejiang University
2016-2020
Beijing University of Chinese Medicine
2015
Zhejiang University
2015
Nanjing University
2011-2014
Collaborative Innovation Center of Advanced Microstructures
2011-2013
Capital Medical University
2011-2012
We report herein a Rh(III)-catalyzed cyclization of N-nitrosoanilines with alkynes for streamlined synthesis indoles. The synthetic protocol features distinct internal oxidant, N-N bond, as reactive handle catalyst turnover, well hitherto tantalizingly elusive intermolecular redox-neutral manifold, predicated upon C-H activation, the formation five-membered azaheterocycle. compatibility seemingly dichotomous acidic and basic conditions ensures reaction versatility multifarious contexts....
N-nitroso compounds are a versatile class of organic structures that allow expedient access to diversity synthetically useful architectures through demonstrated reactivities. We report herein the development Rh(III)-catalyzed N-nitroso-directed methodology for ortho-olefination arenes. The heightened reactivity endowed by group translates mild reaction conditions, high yields, and synthetic compatibility otherwise elusive substrates (e.g., an unactivated olefin, 1-octene). Comprehensive...
A silver-mediated tandem protocol for the synthesis of quinolines involving oxidative coupling/cyclization N-arylimines and alkynes has been developed. We demonstrated that scenario-dependent metalation could occur either at ortho C–H bond an N-arylimine through protonation-driven enhancement acidity or terminal alkyne by virtue carbophilic π-acidity silver. The diverse set mechanistic manifolds implemented with a single type experimental points toward importance stringent reactivity...
<title>Abstract</title> <bold>Background: </bold>Epigenetic regulator lactate, a glycolysis product, affects gene expression via histone lactylation, promoting tumor growth and immunosuppression. But its related genes' role in thyroid carcinoma (THCA) remains unclear. <bold>Methods: </bold>Lactylation - genes from TCGA were consensus clustered. DEGs between clusters analyzed Cox regression, Random_forest, LASSO to create Lactylation High/Low risk signature. data was split for validation....
Differentiation of human hepatic progenitor cells to functional hepatocytes holds great potential develop new therapeutic strategies for liver disease and provide a platform drug toxicity screens identification novel pharmaceuticals. We report here that fetal (hFHPCs) efficiently differentiate hepatocyte-like by continuous exposure combination soluble factors 7 days in vitro. compared the effect hepatocyte growth factor (HGF), oncostatin M (OSM), dexamethasone (DEX), or on expression...
Background and aims: Biological mechanisms that control liver regeneration remain poorly defined.However, these are remarkable issues in the clinic affect management of hepatic loss caused by surgery, traumatic injury, chronic infection, or poisoning.Increasing evidence has shown various growth factors, cytokines, metabolic signaling pathways regenerative process.Our aim is to study effect bromodomain extraterminal (BET) protein inhibition on its mechanism.Methods: We studied role BET...
Background. Graft rejection continues to be a major barrier long-term engraftment after transplantation. Autophagy plays an important role in cardiac injury pathogenesis. The bromodomain and extraterminal protein inhibitor (S)-tert-butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate (JQ1) inhibits inflammatory responses. However, the beneficial effect of JQ1 on transplant potential autophagy protective graft survival are yet...
Three cadmium compounds, [Cd2L2Cl(C6H5O7)] n (1), [CdLCl2] (2), and [CdL2(NO3)](NO3) · 2H2O (3) (L = 4′-Ph-terpy), were synthesized by hydrothermal methods from 4′-Ph-terpy salts. The structure of 1 consists a helical with cadmiums coordinated ligands chloride bridged citrate, constructing chiral 1-D polymeric compound. in 2 is five-coordinate, bound to one tridentate terpyridine ligand two chlorides, exhibiting neutral mononuclear unit an irregular CdN3Cl2 polyhedron. Compound 3 shows...
The correct functioning of hepatocytes requires the establishment and maintenance hepatocyte polarity. However, mechanisms regulating generation polarity are not completely understood. differentiation human fetal hepatic progenitor cells (hFHPCs) into functional provides a powerful in vitro model system for studying molecular governing development. In this study, we used two-stage protocol to generate polarized hepatocyte-like (HLCs) from hFHPCs. Global gene expression profiling was...
Increased levels of interleukin-18 (IL-18) and high mobility group box 1 protein (HMGB1) have been reported in patients with calcific aortic valve disease (CAVD). However, the role IL-18 HMGB1 modulation valvular interstitial cell (VIC) phenotype remains unclear. We hypothesized that mediates IL-18-induced myofibroblastic transition VICs.The expression IL-18, α-smooth muscle actin (α-SMA) human valves was evaluated by immunohistochemical staining, real-time polymerase chain reaction...
Background: The liver coordinates a series of metabolic adaptations to maintain the energy balance system and provide adequate nutrients key organs, tissues cells during starvation. However, mediators underlying molecular mechanisms that mediate these fasting-induced adaptive responses remain unclear. Materials methods: Male wild-type C57BL/6J littermates (8-weeks-old) were intraperitoneally injected with MCC950 or vehicle, then randomly divided into three groups: fed, fasted, refed. Plasma...
Browning of white adipose tissue (WAT) has been recognized as an important strategy for the treatment obesity, insulin resistance, and diabetes. Enoyl coenzyme A hydratase 1 (ECH1) is a widely known enzyme involved in lipid metabolism. However, whether how ECH1 implicated browning WAT remain obscure. Adeno-associated, virus-mediated genetic engineering was used investigations mouse models obesity induced by high-fat diet (HFD) or cold exposure. Metabolic parameters showed that overexpression...
Rab1A not only regulates eukaryotic secretion, autophagy and intracellular traffic, but also extensively participates in the development of cancer. Thus, we collected data to investigate clinical value cancers.
Abstract The morbidity and death rates of calcified aortic valves|calcific valve (CAV) disease (CAVD) remain high for its limited therapeutic choices. Here, we investigated the function, potential, putative mechanisms Enoyl coenzyme A hydratase 1 (ECH1) in CAVD by various vitro vivo experiments. Single‐cell sequencing revealed that ECH1 was predominantly expressed interstitial cells significantly reduced CAVs. Overexpression calcification ApoE −/− mice treated with cholesterol diet, while...
Although serum AFP level is increased in the AFP-producing gastric cancer (GC) patient, GC may become recurrent without re-elevation of level. Therefore, novel characteristics such as other biomarkers are to be explored.35 AFP-GC and 48 non-AFP-GC patients were included. Our present study revealed that blood type O (15 cases, 42.8%) A (18 37.5%) predominantly observed among patients, respectively. Intriguingly, least consistently was AB (8.5%, 14.6%). Among pre-operative levels weakly...
Summary Aortic valve (AoV) calcification is common in aged populations. Its subsequent aortic stenosis has been linked with increased morbidity, but still no effective pharmacological intervention. Our previous data show endoplasmic reticulum ( ER ) stress involved AoV calcification. Here, we investigated whether deficiency of downstream effector CCAAT /enhancer‐binding protein homology CHOP may prevent development was evaluated Apoe −/− mice n = 10) or dual deficiencies ApoE and (Apoe , fed...