A5100780557- Synthesis and Characterization of Heterocyclic Compounds
- Cancer-related Molecular Pathways
- DNA and Nucleic Acid Chemistry
- Sleep and related disorders
- Click Chemistry and Applications
- Cancer therapeutics and mechanisms
- Sleep and Wakefulness Research
- Visual perception and processing mechanisms
- Adsorption and biosorption for pollutant removal
- Mesenchymal stem cell research
- Vestibular and auditory disorders
- Supramolecular Chemistry and Complexes
- Renal Transplantation Outcomes and Treatments
- Cardiovascular Function and Risk Factors
- Musculoskeletal synovial abnormalities and treatments
- Cholinesterase and Neurodegenerative Diseases
- Osteoarthritis Treatment and Mechanisms
- Minerals Flotation and Separation Techniques
- Transplantation: Methods and Outcomes
- T-cell and B-cell Immunology
- Porphyrin and Phthalocyanine Chemistry
- Acupuncture Treatment Research Studies
- Immune cells in cancer
- Radiopharmaceutical Chemistry and Applications
- bioluminescence and chemiluminescence research
Shanghai Institute of Organic Chemistry
2021-2025
Zhongshan Hospital
2021-2025
Fudan University
2021-2025
First Affiliated Hospital of Henan University
2024
Harvard University
2024
Sun Yat-sen University
2013-2024
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Chaohu Hospital of Anhui Medical University
2021-2023
East China University of Science and Technology
2023
Tianjin Normal University
2022-2023
Purpose: To examine whether associations exist between chronic insomnia disorder (CID) and overlooked inflammatory factors (Serum amyloid protein A [SAA]), tumor necrosis factor [TNF]-α, granulocyte-macrophage colony-stimulating [GM-CSF], regulated on activation normal T cell expressed presumably secreted [RANTES]). Patients Methods: total of 65 CID patients 39 sex- age-matched good sleeper (GS) controls participated in this study. They completed a baseline survey to collect data...
This work introduces a novel α,α-diester-δ-vinylvalerolactone as dipolar precursor in palladium-catalyzed [6 + 4] cycloaddition reaction with azadienes, resulting the production of ten-membered heterocycles.
Objectives To examine serum concentrations of aquaporin-4 (AQP4), connexin-30 (CX30), connexin-43 (CX43), and their correlations with cognitive function in the patients chronic insomnia disorder (CID). Methods We enrolled 76 subjects CID 32 healthy controls (HCs). Serum levels AQP4, CX30, CX43 were measured by enzyme-linked immunosorbent assays. Sleep quality was assessed Pittsburgh Quality Index (PSQI) polysomnography, mood evaluated 17-item Hamilton Depression Rating Scale 14-item Anxiety...
Kaolinite nanospheres with hierarchical structures were synthesized via dehydration-rehydration technique through calcined-hydrothermal route. The microstructure of samples characterized and analyzed by diverse techniques. results show that after hydrothermal treatment, the layered pseudo-hexagonal kaolinite particles transformed to structure nanospheres. exhibit large specific surface area 157.1 m2 g-1 narrow mesoporous size distribution. adsorption properties systematically investigated...
Background. Graft rejection continues to be a major barrier long-term engraftment after transplantation. Autophagy plays an important role in cardiac injury pathogenesis. The bromodomain and extraterminal protein inhibitor (S)-tert-butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate (JQ1) inhibits inflammatory responses. However, the beneficial effect of JQ1 on transplant potential autophagy protective graft survival are yet...
To distinguish insomnia comorbid with depression (ICD) from chronic disorder (CID) by exploring the relationship between serum levels of frequently overlooked anti-inflammatory cytokines and cognitive function.A total 42 ICD patients, 63 CID healthy control subjects were enrolled in study. The Pittsburgh Sleep Quality Index Hamilton Depression Rating Scale used to assess sleep quality severity, respectively. Chinese-Beijing version Montreal Cognitive Assessment scale (MoCA-C) Nine-Box Maze...
To investigate changes and links of stress high sleep reactivity (H-SR) on the macro-structure orderliness cortisol levels in good sleepers (GS).Sixty-two GS (18-40 years old) were recruited, with 32 group 30 control group. Each was further divided into H-SR low SR subgroups based Ford Insomnia Response to Stress Test. All participants completed two nights polysomnography a laboratory. Before conducting second night, Trier Social Test saliva collected.The duration NREM stages 1, 2 (N1, N2)...
Background: Accumulating evidence indicates that mesenchymal stem cells (MSCs) are precursors of myofibroblasts, which play a vital role in renal fibrosis. The close interaction between MSCs and other immune regulates the development multiple fibrosis-related diseases. However, effect myeloid-derived suppressor (MDSCs) on remains unexplored. Here, we investigated MDSCs myofibroblastic differentiation MSCs. Methods: were induced to undergo with transforming growth factor beta 1 (TGF-β1)....
Childhood emotional neglect (CEN) refers to a failure meet the basic needs of child, which can seriously impact interpersonal communication and psychological health in young adults. Emotional face processing is critical communication; however, whether CEN affects this adults has not been investigated. Therefore, current study aimed explore effects on Using Child Trauma Questionnaire, an online survey was conducted with 5010 students from four universities Tianjin, China. After interviews...
Abstract The ability to stably decode brain activity is crucial for brain-machine interfaces (BMIs), which are often compromised by recording instability due immune responses and probe drifting. In addition, many regions undergo intrinsic dynamics such as “representational drift”, in neural activities associated with stable sensation action continually change over time. this study, we employed tissue-like flexible electrode arrays visual stimulus-dependent single-unit potentials the mouse...
Although serum AFP level is increased in the AFP-producing gastric cancer (GC) patient, GC may become recurrent without re-elevation of level. Therefore, novel characteristics such as other biomarkers are to be explored.35 AFP-GC and 48 non-AFP-GC patients were included. Our present study revealed that blood type O (15 cases, 42.8%) A (18 37.5%) predominantly observed among patients, respectively. Intriguingly, least consistently was AB (8.5%, 14.6%). Among pre-operative levels weakly...
Myeloid-derived suppressor cells (MDSCs) can prevent allograft rejection and induce immune tolerance in transplantation models. Previous studies have demonstrated that inhibition of mTOR signaling enhance the MDSC protective effect heart (HTx) by promoting expansion. In addition, is related to autophagy. The present study investigated mechanism mTOR-deficient monocytic MDSCs (M-MDSCs) mouse HTx. Myeloid-specific conditional knockout mice were generated obtain mTOR-/- M-MDSCs. proliferation...
Dendritic cells (DCs) are important targets for eliciting allograft rejection after transplantation. Previous studies have demonstrated that metabolic reprogramming of DCs can transform their immune functions and induce differentiation into tolerogenic DCs. In this study, we aim to investigate the protective effects mechanisms monomethyl fumarate (MMF), a bioactive metabolite fumaric acid esters, in mouse model allogeneic heart Bone marrow-derived harvested treated with MMF determine impact...
To observe the effect of electroacupuncture (EA) at "Tianshu" (ST 25) and "Shangjuxu" 37) on mental state, visceral sensitivity protein expression nerve growth factor (NGF), tyrosine kinase receptor A (TrkA) transient potential vanilloid 1 (TRPV1) colonic tissue in diarrhea-predominant irritable bowel syndrome (IBS-D) rats, to explore its possible mechanism treating IBS-D.A total 36 male SD rats SPF grade were randomized into a blank group, model an EA group western medication 9 each group....
Mesenchymal stem cells (MSCs) are the hotspots of cellular therapy due to their low immunogenicity, potent immunoregulation, and unique renoprotection. The present study aimed investigate effects periosteum-derived MSCs (PMSCs) in ischemia-reperfusion (IR)-mediated renal fibrosis.Using cell proliferation assay, flow cytometry, immunofluorescence, histologic analysis, differences characteristics, renoprotection PMSCs were compared bone marrow-derived (BMSCs), most frequently studied therapy....
BACKGROUND Although our previous studies revealed the role of Tregs (regulatory T cells) and MDSCs (myeloid-derived suppressor in a pre-sensitized cardiac transplant model, interplay between NK cells, neutrophils, macrophages remain undefined. MATERIAL AND METHODS Mice heart transplantation with skin pre-sensitization was performed, which prolonged-cold ischemia time (PCI) used for donor treatment. Syngeneic heterotopic recipients PCI were treated PC61 (monoclonal anti-CD25 antibodies),...
Representational momentum (RM) refers to the phenomenon in which an observer's judgment of final location a previously viewed moving target is often displaced forward direction motion. This adaptive mechanism that compensates for neural processing delays and closely associated with visual cortex function. However, impact age-related decline function on manifestations RM remains unclear. The present study examined differences effect between older (