A novel and efficient method for the regiospecific synthesis of polysubstituted furan aldehydes/ketones has been developed via a copper(I)-catalyzed rearrangement/dehydrogenation oxidation/carbene oxidation sequence 1,5-enynes in situ formed from alkynols diethyl but-2-ynedioate under atmospheric pressure. The domino reaction proceeds smoothly mild conditions with commercially available catalysts affords highly functionalized furans moderate to good yields.

The Fe(ClO(4))(3)-catalyzed intramolecular rearrangement/cyclization/oxidation reaction sequence for the synthesis of alpha-carbonyl furan derivatives from electron-deficient alkynes and 2-yn-1-ols is reported.

Hearing loss is a major public health problem faced all over the world and has now become one of prevalent chronic diseases among world's population. Most sensorineural hearing in human ear caused by structural damage irreversible degeneration hair cells(HCs) cochlea. However, current research, microstructure organ Corti (OC) within cochlea mostly ignored, which cannot explore 3D overall structure HCs. In this study, multi-scale cochlear model containing spiral OC developed based on...

This paper presents the study of negative skin friction superlong pile caused by soil settlement under large-scale surcharge loading. Based on displacement equilibrium principle and transfer matrix method, with introduction a load model considering shaft resistance softening, analytical loading is established three-dimensional consolidation along loading, compression deformation pile, around pile-end. Three-dimensional Biot used to derive surrounding formula simplified using Laplace Hankel...

Vortex-induced vibration of twin tandem square cylinders at an inclined angle 45° to the fluid, i.e., diamond mass ratio m* = 3, is numerically investigated Reynolds number Re 100 and reduced velocity Ur 3–18. This paper focuses on effects cylinders' spacing L* (=L/B, where L center-to-center B characteristic length) ranging from 2 6 oscillation responses two-degree-of-freedom cylinders. The results indicate that wake structure experiences two gap flow patterns, reattachment co-shedding...

Abstract A novel cheap and simple amperometric biosensor, based on the immobilization of glucose oxidase (GOD) into anionic clay; layered double hydroxides (LDHs) [Zn 3 ‐Al‐Cl] is presented. GOD can be entrapped in LDHs gel via electrostatic interaction. Amperometric detection with an unmediated sensor at 0.6 V (vs. SCE) results a rapid response (5 s), wide linear range 0.001–12 mM, as well good operational stability. The low limit was 0.1 μM σ . apparent Michaelis‐Menten constant ( K $\rm{...

Abstract The mechanical properties of graphene/hexagonal boron nitride (G/h-BN) heterobilayer nanosheets coupled by interlayer sp 3 bonds and defects have been investigated using the molecular dynamics (MD) simulation. For this purpose, two kinds geometric imperfection (including rhombus square nanopore) are formed in G/h-BN nanosheets. effects adding nanopore diameter, fraction, influence different position nanostructure on investigated. result shows that when coexist, defective graphene...

In this study, we investigate the coupling of an internal field (defect field-sp3 bonds and nanopores) external (strain temperature). Simultaneously, provide a design idea hybrid materials. The mechanical properties materials under condition were studied. When nanopores sp3 are considered simultaneously, found that (sp3 defects) (temperature strain fields) have negative chain reaction on BN-graphene-BN/BN vertically-stacked nanostructures, will gradually increase with change in parameters...

Abstract We report the fabrication of a highly sensitive dopamine biosensor based on entrapment tyrosinase into CaCO 3 nanoparticles at Multiwalled Carbon Nanotube (MWCNT) electrodes. acts as host matrix for and MWCNT provides porous conductive network enhancing enzyme immobilization electrochemical transduction reaction by boosting amplification phenomenon involved in biosensing catechol dopamine. The comparison performance ‐tyrosinase electrodes with without film clearly indicates...

The current researches on soil-pile interaction under combined action of axial and lateral loads are mainly focused the short or middle-long piles in a homogeneous soil. practice for design subjected to both commonly considers two separately. In this paper, super-long pile group stratified soils vertical pile-soil with cap contact ground all simulated together by three-dimensional nonlinear numerical model. influence loading stresses bending moments is analyzed. addition, effect response...

One of the miraculous functions graphene is to use its defects alter material properties composites and, thereby, expand application in other fields. In this paper, various have been created by using ion irradiation. Defective sandwiched between two copper layers. A numerical model Graphene/Copper layered after irradiation damage was established molecular dynamics method. The effects and temperature coupling on defective graphene/copper were studied. results show that there are a lot empty...

The quasi-three-dimensional effect induced by functional groups (FGo) and the in-plane stress structural deformation grain boundaries (GBs) may produce more novel physical effects. These effects are particularly significant in high-temperature environments different from behavior bulk materials, so its mechanism is worth exploring. Considering external field (strain temperature field), internal (FGo GBs) of distance between FGs GBs on bonding energy, configuration transition, distribution...