A5069335515- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Diet and metabolism studies
- Respiratory viral infections research
- Biochemical Analysis and Sensing Techniques
- Wnt/β-catenin signaling in development and cancer
- Phagocytosis and Immune Regulation
- Viral gastroenteritis research and epidemiology
- Lipid metabolism and disorders
- Hippo pathway signaling and YAP/TAZ
- Neonatal Respiratory Health Research
- Hepatitis B Virus Studies
- Reproductive System and Pregnancy
- Cancer-related gene regulation
- Celiac Disease Research and Management
- Diabetes and associated disorders
- Immune Response and Inflammation
- Liver Disease and Transplantation
University of Hong Kong
2016-2024
Chinese University of Hong Kong
2024
Queen Mary Hospital
2023
Jinan University
2017
BackgroundGut dysbiosis is present in chronic hepatitis B virus (HBV) infection. In this study, we integrated microbiome and metabolome analysis to investigate the role of gut virological response nucleos(t)ide analogues (NAs) treatment.MethodsChronic HBV patients were prospectively recruited for steatosis fibrosis assessments via liver elastography, with full-length 16S sequencing performed identify compositional microbiota differences. Fasting plasma bile acids quantified by liquid...
Epidemiological data provide strong evidence of dramatically increasing incidences many autoimmune diseases in the past few decades, mainly western and westernized countries. Recent studies clearly revealed that 'Western diet' increases risk at least partially via disrupting intestinal tight junctions altering construction metabolites microbiota. However, role high sucrose cola beverages (HSCBs), which are one main sources added sugar diet, is barely known. Recently, a population study...
Background: Mutation and downregulation of FAT atypical cadherin 4 (FAT4) are frequently detected in HCC, suggesting a tumor suppressor role FAT4. However, the underlying molecular mechanism remains elusive. Methods: CRISPR-Cas9 system was used to knockout FAT4 ( -KO) normal human hepatic cell line L02 investigate impact loss on development HCC. RNA-sequencing xenograft mouse model were study gene expression tumorigenesis, respectively. The mechanistic basis hepatocarcinogenesis elucidated...
Non-alcoholic fatty liver disease (NAFLD), the world's most common chronic disease, is increasingly linked to gut dysbiosis. Paneth cells secrete antimicrobial peptides that regulate microbiome, but their role in pathogenesis of NAFLD remains unclear. Here, we determine changes development and microbial composition function via injection dithizone can pharmacologically deplete granules cells. Eight-week-old C57BL/6J male mice (n = 31) were given a high-fat diet (HFD) or standard control for...
Toll plays an important role in innate immunity and embryonic development lower-ranked animals, but mammals, the homolog toll-like receptors (TLR) are reported to facilitate postnatal of only. Here, we discovered a TLR5 placental development. Tlr5 was highly transcribed during placenta-forming functional phases. deletion led smaller labyrinthine zone lower embryo weight, size overcorrected, resulting higher body weight. Examination TLR5-deficient conceptus revealed decrease nuclear...