A5011371462- Single-cell and spatial transcriptomics
- Conducting polymers and applications
- Reproductive Biology and Fertility
- Advanced Battery Materials and Technologies
- Renal and related cancers
- Advancements in Battery Materials
- Silicon Effects in Agriculture
- HIV Research and Treatment
- Ruminant Nutrition and Digestive Physiology
- Supercapacitor Materials and Fabrication
- Reproductive System and Pregnancy
- Advanced battery technologies research
- Vitamin C and Antioxidants Research
- Covalent Organic Framework Applications
- Immune Cell Function and Interaction
- Prenatal Screening and Diagnostics
- Hepatitis C virus research
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- Hydrogels: synthesis, properties, applications
- Agriculture, Soil, Plant Science
- Bone Tissue Engineering Materials
- Plant-Microbe Interactions and Immunity
- Aluminum toxicity and tolerance in plants and animals
- Advanced Polymer Synthesis and Characterization
Leiden University Medical Center
2019-2024
Guangzhou University of Chinese Medicine
2023-2024
Zhejiang University
2016-2024
Ji Hua Laboratory
2024
Harbin Institute of Technology
2024
Westlake University
2024
Guizhou University
2022-2023
First Affiliated Hospital Zhejiang University
2023
Jilin University
2014-2023
Lanzhou Petrochemical Polytechnic
2021-2023
Abstract The ovary is perhaps the most dynamic organ in human body, only rivaled by uterus. molecular mechanisms that regulate follicular growth and regression, ensuring ovarian tissue homeostasis, remain elusive. We have performed single-cell RNA-sequencing using adult ovaries to provide a map of signature growing regressing populations. identified different types granulosa theca cells detected local production components complement system (atretic) stromal cells. also mixture adaptive...
The current understanding of mammalian kidney development is largely based on mouse models. Recent landmark studies revealed pervasive differences in renal embryogenesis between and human. scarcity detailed gene expression data humans therefore hampers a thorough human the possible developmental origin diseases. In this paper, we present single-cell transcriptomics study fetal kidney. We identified 22 cell types host marker genes. Comparison samples from different ages continuous changes...
During human fetal development, sex differentiation occurs not only in the gonads but also adjacent developing reproductive tract. However, while cellular composition of male and female is well described, that tract remains poorly characterized. Here, we performed single-cell transcriptomics on together with from first second trimesters, highlighting morphological molecular changes during differentiation. We validated different cell populations compared signatures between as sexes, to...
Bacterial wilt is a devastating disease of tomato caused by soilborne pathogenic bacterium Ralstonia solanacearum. Previous studies found that silicon (Si) can increase resistance against R. solanacearum, but the exact molecular mechanism remains unclear. RNA sequencing (RNA-Seq) technology was used to investigate dynamic changes root transcriptome profiles between Si-treated (+Si) and untreated (-Si) plants at 1, 3, 7 days post-inoculation with The contents salicylic acid (SA), ethylene...
Abstract Active packaging film was developed by incorporating Lycium barbarum fruit extract (LFE) into chitosan. The effects of LFE on physicochemical properties the chitosan/LFE films were evaluated. When weight ratio to chitosan increased from 0:1 1:1, DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging activity near ten-folds and reached up 35.8%; water vapour permeability decreased 43.0% 5.67 g m mm−2 day−1 kPa−1, solubility 100% 24.52% because interactions between hydrophilic...
Electrocatalysis is critical to the performance displayed by sulfur cathodes. However, constituent electrocatalysts and reactants have vastly different molecular sizes, which ultimately restrict electrocatalysis efficiency hamper device performance. Herein, authors report that aggregates of cobalt single-atom catalysts (SACs) attached graphene via porphyrins can overcome challenges associated with catalyst/reactant size mismatch. Atomic-resolution transmission electron microscopy X-ray...
Two-dimensional (2D) organic materials hold great promise for use in a multitude of contemporary applications due to their outstanding chemical and physical properties. Herein, 2D sheets poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS) are prepared from commercially available PEDOT:PSS suspension using ice as template. The grow the boundaries crystals polymers "squeezed" out when water solidifies. mechanical robustness can be enhanced by incorporating WO3 nanowires, PSS...
Metal–organic frameworks (MOFs) are promising electrochromic materials known for their rapid response speed and ability to transition through multiple colors. However, typical MOF films suffer from slow times poor stability due inappropriate pore sizes, weak substrate interaction, limited bond reversibility. This study addresses these challenges by modifying F-doped SnO2 with 4-mercaptobenzoic acid fabricating Ni-IRMOF-74@MBA using 3,3′-dihydroxy-4,4′-biphenyldicarboxylic acid. The optimized...
Electrochromism is the process by which a material applies small electrical signal to change optical properties (transmittance, reflectance, absorptivity and emissivity) of reversibly or permanently through REDOX reactions resulting from ion electron embedding/ejection. Metal-organic framework (MOF) are advantageous materials for electrochromic application due their high porosity, large specific surface area orderly pore structure, that promotes adsorption electrolyte ions, diffusion charge...
Cdc42, a member of Rho family small guanosine triphosphatases (GTPases), is critical for cartilage development. We investigated the roles Cdc42 in osteoarthritis and explored potential mechanism underlying Cdc42-mediated articular degeneration subchondral bone deterioration. highly expressed both mouse model with surgical destabilization medial meniscus (DMM) knee joints. Specifically, genetic disruption knockdown expression, or inhibition activity robustly attenuates DMM-induced...
Abstract Background More than half of the colorectal cancer (CRC) patients will develop liver metastasis that underlies mortality. In hepatic tumor microenvironment, interplay between CRC cells and stellate (HSCs), activation HSCs to become carcinoma-associated fibroblasts (CAFs) further promote development. Nevertheless, critical signaling molecule involved in these processes remains unknown, which hinders development effective therapeutic agents for treatment metastatic (mCRC). Methods...
Significance NOD-like receptors (NLRs) are traditionally recognized as key surveillance pattern recognition (PRRs) during innate immune regulation. Several NLRs exhibit highly restricted expression in mammalian germline, where their physiological functions largely unknown. Here we report that Nlrp14, an NLR specifically expressed testis and ovary, plays a critical role regulating germ cell differentiation reproduction. Nlrp14 deficiency led to decreased primordial cell-like (PGCLC) vitro...
Human ovarian folliculogenesis is a highly regulated and complex process. Characterization of follicular cell signatures during this dynamic process important to understand follicle fate (to grow, become dominant, or undergo atresia). The transcriptional signature human oocytes granulosa cells (GCs) in early-growing ovulatory follicles have been previously described; however, that with surrounding GCs small antral not studied yet. Here, we generated unique dataset single-cell transcriptomics...
Lithium–sulfur (Li–S) batteries have attracted extensive attention due to the high theoretical specific capacity of sulfur (1675 mA h g–1). Despite advantage, utility Li–S is limited by low electrical conductivities and its discharge products (i.e., Li2S2 Li2S) as well "shuttle effect" polysulfides. Herein, a strategy covalently grafting sulfur-containing polymers carbon nanotubes (CNTs) proposed solution problems associated with cathodes. The are grafted CNTs using an "inverse...