A5037815662- Cell death mechanisms and regulation
- Nuclear Structure and Function
- RNA Interference and Gene Delivery
- Corneal Surgery and Treatments
- Ubiquitin and proteasome pathways
- Inflammasome and immune disorders
- Circular RNAs in diseases
- Retinal Development and Disorders
Humboldt-Universität zu Berlin
2022
Charité - Universitätsmedizin Berlin
2022
Freie Universität Berlin
2022
Wenzhou Medical University
2009
BACKGROUND MicroRNAs (miRNAs), which modulate the expression of their target genes, are commonly involved in stimulating and adjusting many processes that result cardiovascular diseases, contain cardiac ischemia/reperfusion (I/R) damage. However, role miR-149 pyroptosis mediated myocardial I/R damage remains unclear. MATERIAL AND METHODS Real-time polymerase chain reaction was performed to measure FoxO3 stimulated H9C2 cells. The cell proliferation, pyroptosis-related inflammatory genes...
The development of non-invasive ocular drug delivery systems is practical importance in the treatment retinal disease. In this study, we evaluated efficacy transactivator transcription protein transduction domain (TAT-PTD, TAT(49-57)) as a vehicle to deliver acidic FGF (aFGF) retina rats. TAT-conjugated aFGF-His (TAT-aFGF-His) exhibited efficient penetration into following topical administration surface. Immunochemical staining with anti-His revealed that TAT-aFGF-His proteins were readily...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging caused by dominant mutation in the LMNA gene. Previous research has shown that ectopic expression of catalytic subunit telomerase (hTERT) can elongate telomeres patients' fibroblasts. Here, we established five immortalized HGP fibroblast cell lines using retroviral infection with hTERT. Immortalization enhanced proliferative life span at least 50 population doublings (PDs). The number cells typical senescence signs was...