A5101511962- Cancer-related molecular mechanisms research
- Rheumatoid Arthritis Research and Therapies
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- Sleep and related disorders
- Osteoarthritis Treatment and Mechanisms
- Chemokine receptors and signaling
- Acute Myeloid Leukemia Research
- Eosinophilic Disorders and Syndromes
- Inflammatory mediators and NSAID effects
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Pain Management and Opioid Use
- Kruppel-like factors research
- Diabetes Treatment and Management
- Angiogenesis and VEGF in Cancer
- Neuroendocrine Tumor Research Advances
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Antifungal resistance and susceptibility
- Systemic Lupus Erythematosus Research
- Oral and gingival health research
- Reproductive tract infections research
- Fungal Infections and Studies
Central Hospital of Zibo
2017-2023
Henan Provincial People's Hospital
2018
Zhengzhou University
2018
Mayo Clinic in Arizona
2017
Obstetrics and Gynecology Hospital of Fudan University
2015
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2015
People's Hospital of Xinjiang Uygur Autonomous Region
2011
This study probes into the impact and mechanisms of PRDX6 on ferroptosis multiple myeloma (MM). expression in MM cells were determined using Western blotting qRT-PCR. treated with pLKO-shPRDX6 vectors expressing shRNA alone or combination Erastin/ferrostatin-1 (ferroptosis activator/inhibitor) 740Y-P (PI3K/AKT pathway activator). Cell viability, apoptosis, Fe2+ concentration, ROS levels examined CCK-8, flow cytometric analysis, iron ion detection, DCFH-DA assay, ELISA. Malondialdehyde (MDA)...
To evaluate the mutation frequency of JAK2 V617F, exon 12, MPL 10, and CALR 9 value combined tests in diagnosis BCR-ABL1–negative myeloproliferative neoplasms (MPNs). In current study, mutations were analyzed 929 Chinese patients with MPN, including 234 cases polycythemia vera (PV), 428 ETs, 187 PMFs, 80 unclassifiable MPNs (MPN-Us). Our result showed that positive rate any four PV, ET, PMF, MPN-U was 89.3%, 83.4%, 87.2%, 77.5%, respectively, which significantly improved diagnostic rate,...
Rheumatoid arthritis (RA) is the most frequently occurring inflammatory arthritis. The present study was performed to characterize role of microRNA-101-3p (miR-101-3p) and prostaglandin-endoperoxide synthase 2 (PTGS2) in inflammation biological activities fibroblast-like synoviocytes (FLSs) RA.Initially, miR-101-3p PTGS2 expression RA tissues patients rats detected by qRT-PCR Western blot analysis. Rat model type II collagen-induced (CIA) adopted simulate RA, followed injection mimics or...
In our multicenter study, we studied the distribution of Candida species in vulvovaginal candidiasis patients and investigated antifungal susceptibility profile genotype albicans vaginal swab. A total 115 strains were detected 135 clinical isolates. Minimum inhibitory concentration determinations showed that 83% 81% susceptible to fluconazole voriconazole. Randomly amplified polymorphic DNA analysis (RAPD) was applied identify clonally related isolates from different at local level. All...
The aim of the study was to changes in brain structure and functional connectivity primary insomnia (PI) patients, as well explore biological characteristics PI abnormality pathophysiological mechanism underlying abnormal under depression. Voxel-based morphometry (VBM) technique resting-state magnetic resonance imaging (rs-fcMRI) techniques were used investigate rs-fc light-moderate with depression (PID) patients; healthy individuals normal control (NC) group. differences between 3 groups,...
Rheumatoid arthritis (RA) is a systemic autoimmune disease and collagen-induced (CIA) an animal model for RA. Micheliolide (MCL) novel compound with strong anti-inflammatory effects. The present study was conducted to evaluate the therapeutic effects of MCL on Mice were randomly divided into four groups CIA mice treated methotrexate (MTX), dimethyl sulfoxide. A score associated severity assigned alternate days from 22nd day 60 days. Histopathological changes serum levels cytokines measured...
The proinflammatory cytokine tumor necrosis factor-α (TNF-α)-induced degradation of extracellular matrix (ECM), such as type II collagen in chondrocytes, plays an important role the development osteoarthritis (OA). Telmisartan, angiotensin (Ang-II) receptor blocker, is a licensed drug used for treatment hypertension. However, effects Telmisartan damage to chondrocytes and progression OA are unknown. In this study, we found that with attenuated TNF-α-induced oxidative stress by reducing...
Gene expression can be altered through RNA interference (RNAi), including microRNA (miRNA) or small interfering RNA. Alterations of miRNAs in rheumatoid arthritis (RA) have been reported, however, the components RNAi machinery RA remain to fully elucidated. The aim present study was detect levels Dicer, Argonaute2 and Drosha, machinery, peripheral blood mononuclear cells patients with RAusingreverse transcription‑quantitative polymerase chain reaction, compare results disease activity...
The increased level of interleukin-6 (IL-6) plays a significant role in the pathogenesis rheumatoid arthritis (RA). Specific blockade IL-6 or its receptor has been used successfully treating RA. MicroRNAs can regulate gene expression and act as regulators target genes. Manipulation specific microRNAs provides novel therapeutic strategy for treating/preventing diseases. This study explored miR-98-5p regulation fibroblast-like synoviocytes (RA-FLSs).Real-time PCR was to detect RA-FLSs normal...
This study was aimed to investigate the influence of short hairpin RNA (shRNA) on proliferation human leukemia cell line THP-1. The shRNA targeting site 732-752 DOT1L mRNA designed and chemically synthesized, then a single-vector lentiviral, tet-inducible shRNA-DOT1L system (Plko-Tet-On) generated. Thereafter, THP-1 cells with lentivirus were infected create stable regulatable expression. expression in assayed by RT-PCR. Effect detected MTT method,and change colony forming potential analyzed...
Background IgG4-related disease (IgG4-RD) is a systemic inflammatory which involves various organs such as the pancreas, lacrimal gland, salivary retroperitoneum, and so on. These can be affected concomitantly. 18-Fluorodeoxyglucose positron emission tomography computed (FDG-PETCT) examination identify active inflammation detect multiple organ involvement simultaneously. Pericardial rare in IgG4-RD, early detection treatment greatly improve prognosis of patients. Case summary We reported...
Objective To summarize the experience of internet-based online database orthopedic failure surgery.Methods Based on OrthoChina project,a sub-database for surgery was established,open to surgeons viewing,uploading,and sharing experience.All cases were uploaded by surgeon users registering in project from 25 August 2006 31 December 2007 summarized.Results 102 had been database,in which 87 caused internal instrumentation,5 external fixation,7 conservative treatment,and 3 hip...
Objective To investigate the efficacy and safety of initial dose sustained-release oxycodone 30 mg to begin titration in patients with severe cancer pain. Methods One hundred twenty-nine pain at Cancer Prophylactico-Therapeutic Hospital Liaocheng City from May 2013 June 2016, NRS 7 10, were randomly divided into group 20 mg. The received hydrochloride mg, while Then dosage was adjusted 12 h based on assessment during 2 weeks. Numerical rating scale (NRS) recorded 1, 24, 48, 72 weeks...
Objective To explore the laboratory characteristics and diagnostic methods for therapy-related acute megakaryocytic leukemia (t-AMKL). Methods The data of one child with lymphoblastic (ALL) in Blood Disease Hospital Chinese Academy Medical Sciences & Peking Union College September 2014 was retrospectively analyzed. After inducing remission more than 43 months, diagnosed as t-AMKL. Results After diagnosis ALL, given chemotherapy standard childhood ALL regimen. t-AMKL by...