A5100429717- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Monoclonal and Polyclonal Antibodies Research
- Digital Imaging for Blood Diseases
- Radiomics and Machine Learning in Medical Imaging
- Retinal Diseases and Treatments
- Radiopharmaceutical Chemistry and Applications
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Lymphoma Diagnosis and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Galectins and Cancer Biology
- Cardiac Arrest and Resuscitation
- Acute Kidney Injury Research
- Ophthalmology and Visual Impairment Studies
- Ovarian cancer diagnosis and treatment
- Tendon Structure and Treatment
- Injury Epidemiology and Prevention
- Microwave Imaging and Scattering Analysis
- Ocular Diseases and Behçet’s Syndrome
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Tactile and Sensory Interactions
- Electrical and Bioimpedance Tomography
- Radioactivity and Radon Measurements
Sichuan University
2019-2024
West China Hospital of Sichuan University
2019-2024
Peking University First Hospital
2018-2022
Peking University
2018-2022
Weatherford College
2021
Hebei Medical University
2021
Second Hospital of Hebei Medical University
2021
Versus Arthritis
2021
Union Hospital
2021
Jilin University
2021
Background: Increased consumption of fruit and vegetables has been shown to be associated with a reduced risk cognitive impairment dementia in many epidemiological studies. The purpose this study was assess the strength association meta-analysis. Methods: We identified relevant studies by searching Medline, Embase, Cochrane Library electronic databases (from 1970 January 2016). Study were included if they reported relative risks corresponding 95% confidence intervals (CIs) respect frequency...
Although radioimmunotherapy with radiolabeled intact monoclonal antibodies has demonstrated efficacy in the treatment of lymphoma, it provides low tumor-to-normal-tissue radionuclide target ratios and unwanted prolonged radiation exposure to bone marrow. To overcome these obstacles, administration was separated from that antibody by using an anti-IL-2 receptor α single chain Fv-streptavidin fusion protein, followed biotin treat lymphoma or leukemia xenografted mice. This Pretarget approach...
In this paper, we investigate three fundamental problems in the Massively Parallel Computation (MPC) model: (i) grid graph connectivity, (ii) approximate Euclidean Minimum Spanning Tree (EMST), and (iii) DBSCAN. Our first result is a $O(1)$-round Las Vegas (i.e., succeeding with high probability) MPC algorithm for computing connected components on $d$-dimensional $c$-penetration ($(d,c)$-grid graph), where both $d$ $c$ are positive integer constants. such graph, each vertex point coordinates...
In epidemiological studies, exposures of interest are often measured with uncertainties, which may be independent or correlated. Independent errors can characterized relatively easily while correlated measurement have shared and hierarchical components that complicate the description their structure. For some important Monte Carlo dosimetry systems provide multiple realizations exposure estimates been used to represent such complex error structures. While effects on parameter estimation...
Questions exist regarding the causal relationship between malnutrition and stroke outcomes. This study aimed to determine whether nutritional status changes or during hospitalisation could predict 3-month outcomes in acute patients.During a 10-month period, patients who suffered their first within 7 days after onset were included this prospective multi-centre study. The demographic parameters, risk severity factors, factors dysphagia recorded. Nutritional was assessed by 3 anthropometric...
Abstract Radioimmunotherapy of cancer with radiolabeled antibodies has shown promise. α-Particles are very attractive for therapy, especially isolated malignant cells, as is observed in leukemia, because their high linear energy transfer and short effective path length. We evaluated an anti-CD25 [interleukin-2 receptor α (IL-2Rα)] monoclonal antibody, 7G7/B6, armed 211At a potential radioimmunotherapeutic agent CD25-expressing leukemias lymphomas. Therapeutic studies were done severe...
CD30 is a member of the TNF receptor superfamily. Overexpression on some neoplasms versus limited expression normal tissues makes this promising target for antibody-based therapy. Radioimmunotherapy cancer with radiolabeled antibodies has shown promise. In study, we evaluated therapeutic efficacy an anti-CD30 antibody, HeFi-1, armed (211)At in leukemia (karpas299) model and (90)Y lymphoma (SUDHL-1) model. Furthermore, investigated combination therapy (211)At-HeFi-1 unmodified HeFi-1...
Glaucoma's irreversibility, lacking of glaucoma specialists and patient unawareness demand for an economic effective diagnosis system screening.In this study we explore feature selection (FS) technologies to identify the most essential parameters automatic diagnosis. Methods:We compose space from heterogeneous data sources, i.e., retinal image eye screening data.A framework is proposed by exploring multiple ranking schemes a wide range supervised learners.The optimal set derived...
Pathological myopia is a leading cause of visual impairment, and can lead to blindness in children if left undetected. We present bag-of-feature sparse learning based framework automatically recognize pathological retinal fundus images discover the most related features corresponding changes myopia. In phase, codebook for model classification are first learnt, top discovered via concurrently. testing given image, local extracted then quantized with learned obtain global feature. Finally,...
Developing image-based automatic glaucoma diagnosis systems requires a large amount of fundus image groundtruth data, especially that from glaucomatous patients. We develop ACHIKO-K database which contains 258 manually annotated retinal images and their clinical information. All in are taken patients contain rich information on related pathological signs, e.g. hemorrhage, optic nerve drusen cup notching etc. Using our in-house developed marking tool, cup/disc boundaries various signs...
Glaucoma is the one of two major causes blindness, which can be diagnosed through measurement neuro-retinal optic cup-to-disc ratio (CDR). Automatic calculation cup boundary challenging due to interweavement blood vessels with surrounding tissues around cup. A multimodality fusion approach for neuroretinal detection improves accuracy estimation. The algorithm's effectiveness demonstrated on 71 manually segmented retina fundus images collected from Singapore Eye Research Institute. By...
Previous studies using contrast-enhanced imaging for glioma isocitrate dehydrogenase (IDH) mutation assessment showed promising yet inconsistent results, and this study attempts to explore problem by an advanced tracer kinetic model, the distributed parameter model (DP). Fifty-five patients with examined dynamic sequence at a 3.0 T scanner were retrospectively reviewed. The data processed DP, yielding following parameters: blood flow F, permeability-surface area product PS, fractional volume...
Abstract Background This study aimed to assess the predictive value of ratio mean arterial pressure (MAP) corresponding peak rate norepinephrine equivalent dose (NEQ) within first day in patients with shock for subsequent renal replacement therapy (RRT) requirement. Methods Patients were identified using Medical Information Mart Intensive Care IV (MIMIC-IV) database. The relationship was investigated a restricted cubic spline curve, and propensity score matching(PSM) used eliminate...
Min-Redundancy Max-Relevance (mRMR) is a feature selection methodology based on information theory. We explore the mRMR principle for automatic glaucoma diagnosis. Optimal candidate sets are acquired from composition of clinical screening data and retinal fundus image data. An optimized classifier further trained using to find classifier. tested proposed eye records 650 subjects collected Singapore Eye Research Institute. The experimental results demonstrate that new much compact by less...
We explore feature selection methodology for automatic Pathological Myopia detection via learning from an optimal set of features. An mRMR optimized classifier is trained using the candidate to find classifier. tested proposed on eye records approximately 800 subjects collected a population study. The experimental results demonstrate that new much efficient by less than 25% initial set. ranked also enables clinicians better access diagnostic process algorithm. work further step towards...
B-1 cells are innate-like that play important roles in host defense against infection. However, the function of fungi infection remains unclear. Previously we produced IgH transgenic mice TgVH3B4 with VH derived from a natural antibody 3B4 can identify C. albicans, and found were resistant to intraperitoneal (i. p.) intravenous albicans Most peritoneal cavity (PEC) express BCR binds albicans. In present study, explored response by applying i. p. inoculation mice. We was cleared more...