A5059827612- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Urinary and Genital Oncology Studies
- Renal and Vascular Pathologies
- Pediatric Urology and Nephrology Studies
- Cancer-related molecular mechanisms research
- Minimally Invasive Surgical Techniques
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Wound Healing and Treatments
- Urological Disorders and Treatments
- RNA modifications and cancer
- Urologic and reproductive health conditions
- Multiple and Secondary Primary Cancers
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- Organ Donation and Transplantation
- Bone health and osteoporosis research
- Sarcoma Diagnosis and Treatment
- MRI in cancer diagnosis
Shandong Provincial QianFoShan Hospital
2022-2025
Shandong First Medical University
2022-2025
Second Military Medical University
2011-2025
Changhai Hospital
2011-2025
Inner Mongolia Medical University
2025
Jilin University
2025
Shandong University
2021-2024
Beihua University
2023-2024
European Association of Urology
2023-2024
South China University of Technology
2024
Background Although anti-programmed cell death protein 1 (PD-1) immunotherapy is greatly effective in melanoma treatment, low response rate and treatment resistance significantly hinder its efficacy. Tumor ferroptosis triggered by interferon (IFN)-γ that derived from tumor-infiltrating CD8 + T cells contributes to the effect of immunotherapy. However, molecular mechanism underlying IFN-γ-mediated related potentially promising therapeutic strategy warrant further clarification. MicroRNAs...
Until recently, there have been limited options for patients with bone metastatic castration-resistant prostate cancer (BmCRPC) following the failure of or development resistance to docetaxel (DTX), which is one frontline treatments.Sterol regulatory element-binding protein 1 (SREBP1) reported regulate abnormal lipid metabolism and promote progression metastasis (PCa).The siRNA interferes SREBP1 may provide an efficient treatment when combined DTX.Methods: In this study, lipoic acid (LA)...
Recent research has indicated that cuprotosis, or copper induced cell death, is a novel type of death could be utilized as new weapon for cancer management. However, the characteristics and implications such signatures in cancers, especially clear renal (ccRCC), remain elusive.Expression, methylation, mutation, clinical information, copy number variation, functional implication, drug sensitivity data at pan-cancer level were collected from The Cancer Genome Atlas. An unsupervised clustering...
To address the problem that insulator small faults in transmission lines are difficult to identify and combine features of fault images, this paper proposes a detection algorithm based on improved YOLOv8 for targets. Firstly, we use C2f-DCN module backbone extraction network solve it is obtain targets due image deformation caused by compressed pixels. Secondly, add BiFormer attention at bottom network, which can focus insulators complex background improve feature representation capability...
Renal tumour biopsy (RTB) can help in risk stratification of renal tumours with implications for management, but its utilisation varies. Our objective was to report current practice patterns, experiences, and perceptions RTB research gaps regarding small masses (SRMs).
Pyroptosis is essential for tumorigenesis and progression of neoplasm. However, the heterogeneity pyroptosis its relationship with tumor microenvironment (TME) in clear cell renal carcinoma (ccRCC) remain unclear. The purpose present study was to identify pyroptosis-related subtypes construct a prognosis prediction model based on signatures.First, heterogenous subgroups were explored 33 genes ccRCC samples from TCGA, established by LASSO regression verified ICGC database. Then, clinical...
Naringenin is a citrus flavonoid with various biological functions and potential therapeutic agent for skin diseases, such as UV radiation atopic dermatitis. The present study investigates the effect pharmacological mechanism of naringenin on chronic wounds. Using network pharmacology, we identified 163 targets 12 key naringenin. Oxidative stress was confirmed to be main process modulated by transcription factor p65 (RELA), alpha serine/threonine-protein kinase (AKT1), mitogen-activated...
Wound healing is delayed in diabetic patients. Increased autophagy and dysfunction of interfollicular epidermal (IFE) cells are closely associated with wounds. Autophagy plays an important role all stages wound healing, but its the underlying molecular mechanisms not clear. Here, we found that mice had increased wounds compared normal chloroquine, inhibitor autophagy, decreased level improved function IFE cells, accelerated mice. Treatment advanced glycosylation end products (AGEs) resulted...
Partial nephrectomy (PN) has become the standard of treatment for most T1 renal masses and is suitable selected T2 cortical masses. In this setting, management complex (CRM) requires a thorough understanding potential risks benefits both PN radical (RN). Indeed, thanks to advent robotic surgery, indications have expanded include larger tumors CRM, despite associated surgical complexity oncologic risks. The decision-making process CRM with or RN complex. Thus, current review aims explore...
Abstract Background Skin innervation is very important for normal wound healing, and receptor activity-modifying protein 1 (RAMP1) has been reported to modulate calcitonin gene-related peptide (CGRP) function thus be a potential treatment target. This study aimed elucidate the intricate regulatory effect of RAMP1 on skin fibroblast function, thereby addressing existing knowledge gap in this area. Methods Immunohistochemical staining immunofluorescence (IF) were used measure dynamic changes...
Robotic surgery has enhanced minimally invasive procedures with greater precision and control, but high costs have limited its widespread adoption. The Sentire® surgical system is hypothesized to achieve clinical outcomes comparable those of the da Vinci® while demonstrating superior cost-effectiveness in robot-assisted radical prostatectomy (RARP) procedures. This study aimed compare RARP using ®, focusing on efficacy economic impact. A retrospective analysis was conducted at three...