A5101563971- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Urinary and Genital Oncology Studies
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- Hormonal and reproductive studies
- Estrogen and related hormone effects
- Renal cell carcinoma treatment
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Urologic and reproductive health conditions
- Xenotransplantation and immune response
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
- Cancer Immunotherapy and Biomarkers
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Nuclear Receptors and Signaling
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Colorectal Cancer Surgical Treatments
Tianjin Medical University
2016-2025
Second Hospital of Tianjin Medical University
2015-2025
Shanxi Academy of Medical Sciences
2024-2025
Shanxi Medical University
2024-2025
Anhui Medical University
2023
Fuyang City People's Hospital
2023
University of Rochester Medical Center
2006-2020
University of Rochester
2010-2020
Targeting androgens/androgen receptor (AR) functions via androgen deprivation therapy (ADT) remains the standard treatment for prostate cancer. However, most tumors eventually recur despite ADT. Here we demonstrate that AR may function as both a suppressor and proliferator to suppress or promote cancer metastasis. Results from orthotopically recombining stromal WPMY1 cells with epithelial PC3 in mice demonstrated restoring knockdown of suppressed Knockdown CWR22rv1 also resulted increased...
To differentiate roles of androgen receptor (AR) in prostate stromal and epithelial cells, we have generated inducible-(ind)ARKO-TRAMP epithelial-specific ARKO TRAMP (pes-ARKO-TRAMP) mouse models, which the AR was knocked down both epithelium stroma or out epithelium, respectively. We found that loss models resulted poorly differentiated primary tumors with expanded intermediate cell populations. Interestingly, knockdown ind-ARKO-TRAMP mice at earlier stages smaller lower proliferation...
The antiandrogen enzalutamide (Enz) has improved survival in castration resistant prostate cancer (CRPC) patients. However, most patients eventually develop Enz resistance that may involve inducing the androgen receptor (AR) splicing variant 7 (ARv7). Here we report high expression of monoamine oxidase-A (MAO-A) is associated with positive ARv7 detection CRPC following treatment. Targeting MAO-A phenelzine or clorgyline, FDA-approved drugs for antidepression, resensitize (EnzR) cells to...
Abstract Despite being well recognized as the best biomarker for prostate cancer, pathophysiologic roles of prostate-specific antigen (PSA) remain unclear. We report here that tissue PSA may be involved in hormone-refractory cancer progression. Histologic analyses show increased levels are correlated with lower cell apoptosis index and higher proliferation rate tumor specimens. By stably transfecting cDNA into various lines, we found could promote growth androgen receptor (AR)-positive...
Abstract BACKGROUND Androgens and the androgen receptor (AR) play important roles in development of male urogenital organs. We previously found that mice with total AR knockout (ARKO) epithelial ARKO failed to develop normal prostate loss differentiation. have recently knocked out gene smooth muscle cells reduced luminal infolding IGF‐1 production mouse prostate. However, stromal fibroblasts remain unclear. METHODS To further probe fibroblast development, we generated tissue‐selective...
Recent data suggested that tissue human kallikrein 2 (KLK2) might be involved in the carcinogenesis and tumor metastasis of prostate cancer (PCa). However, detailed pathophysiological roles KLK2 PCa remain unclear. We report here may treated as a potential therapeutic target castration-resistant (CRPC). Histologic analyses show increased expression is correlated with higher cell proliferation rate lower apoptosis index CRPC specimens. Adding functional cDNA into high passage LNCaP cells led...
Recent studies have suggested that prostate cancer (PCa) is able to recruit bone marrow derived mesenchymal stem cells (BM-MSCs) promote metastasis. The detailed mechanisms, especially the involvement of stromal cells, remain unclear. We found recruited BM-MSCs might be convert normal fibroblasts more associated fibroblast (CAF)-like characteristics via alteration secreted TGFβ-1. consequences such conversion then enhance PCa growth and invasion. Addition functional TGFβ-1 or interruption...
Background and objectiveCombinations of immune checkpoint inhibitors nab-paclitaxel have achieved significant therapeutic effects in the treatment advanced urothelial carcinoma. Our aim was to assess efficacy safety tislelizumab combined with low-dose patients muscle-invasive bladder cancer (MIBC).MethodsTRUCE-01 a single-arm phase 2 study that included 62 T2-4a N0/X M0 MIBC tumors predominant carcinoma histology. Eligible received three 21-d cycles intravenous 200 mg on day 1 plus 2,...
The androgen receptor (AR) requires coregulators for its optimal function. However, whether AR further need interacting protein(s) their proper function remains unclear. Here we describe transgelin as the first ARA54-associated negative modulator AR. Transgelin suppressed ARA54-enhanced in ARA54-positive, but not ARA54-negative, cells. transactivation via interruption of ARA54 homodimerization and AR-ARA54 heterodimerization, resulting cytoplasmic retention ARA54. Stable transfection LNCaP...
Anabolic signals such as androgens and the growth hormone/insulin-like factor 1 (GH/IGF-1) axis play an essential role in normal development of prostate but also its malignant transformation. In this study, we investigated suppressor cytokine signaling 2 (SOCS2) mediator cross talk between GH potential tumor cancer (PCa). We observed that SOCS2 protein levels assayed by immunohistochemistry are elevated hormone therapy-naive localized prostatic adenocarcinoma comparison with benign tissue....
KIF20A is essential in the process of spindle assembly and cytokinesis regulation. The role during tumorigenesis tumor development has been well studied several cancers. But association between clinical prostate cancer (PCa) not reported yet. In this study, we investigated its potential prognostic effect progression cancer. Real-time quantitative polymerase chain reaction Western blots were used to investigate transcription translation levels 7 pairs fresh PCa tissue adjacent normal tissue....
Abstract The androgen receptor splicing variant 7 (ARv7) that lacks the ligand-binding domain is increasingly considered as a key player leading to enzalutamide (Enz) resistance in patients with prostate cancer (PCa). However, detailed mechanisms of how ARv7 expression regulated and whether it also needs other factors induce maximal Enz remain unclear. Here, we identified microRNA, miR-361-3p, whose lower recurrent PCa, could function via binding 3′UTR ARv7, but not wild type AR, suppress...
Castration resistant prostate cancer (CRPC) is a stage of relapse that arises after various forms androgen ablation therapy (ADT) and causes significant morbidity mortality. However, the mechanism underlying progression to CRPC remains poorly understood. Here, we report YAP1, which negatively regulated by AR, influences (PCa) cell self-renewal development. Specifically, found AR directly regulates methylation YAP1 gene promoter via formation complex with Polycomb group protein EZH2 DNMT3a....