A5022254012- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Plant-Microbe Interactions and Immunity
- Bladder and Urothelial Cancer Treatments
- Colorectal Cancer Treatments and Studies
- Urinary and Genital Oncology Studies
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Gastrointestinal Tumor Research and Treatment
- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Plant Parasitism and Resistance
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Plant tissue culture and regeneration
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Plant Gene Expression Analysis
- Quantum Dots Synthesis And Properties
- Advanced Photocatalysis Techniques
- Polysaccharides and Plant Cell Walls
Weifang Medical University
2021-2022
Chinese Academy of Sciences
2013-2018
State Key Laboratory of Plant Genomics
2013-2018
Institute of Microbiology
2015-2018
University of Chinese Academy of Sciences
2015-2016
University of Hong Kong
2016
Technical Institute of Physics and Chemistry
2016
Abstract Plant-specific TEOSINTE-BRANCHED1/CYCLOIDEA/PCF (TCP) transcription factors play crucial roles in development, but their functional mechanisms remain largely unknown. Here, we characterized the cellular functions of class I TCP factor GhTCP14 from upland cotton (Gossypium hirsutum). is expressed predominantly fiber cells, especially at initiation and elongation stages its expression increased response to exogenous auxin. Induced heterologous overexpression Arabidopsis (Arabidopsis...
Photosplitting water for H2 production is a promising, sustainable approach solar-to-chemical energy conversion. However, developing low-cost, high efficient and stable photocatalysts remains the major challenge. Here we report composite photocatalyst consisting of FeP nanoparticles CdS nanocrystals (FeP/CdS) photogenerating in aqueous lactic acid solution under visible light irradiation. Experimental results demonstrate that highly active with H2-evolution rate 202000 μmol h(-1) g(-1) first...
Accumulating evidence indicates that plant MYB transcription factors participate in defense against pathogen attack, but their regulatory targets and related signaling processes remain largely unknown. Here, we identified a defense-related gene (GhMYB108) from upland cotton (Gossypium hirsutum) characterized its functional mechanism. Expression of GhMYB108 plants was induced by Verticillium dahliae infection responded to the application molecules, including salicylic acid, jasmonic ethylene....
Background and objectiveCombinations of immune checkpoint inhibitors nab-paclitaxel have achieved significant therapeutic effects in the treatment advanced urothelial carcinoma. Our aim was to assess efficacy safety tislelizumab combined with low-dose patients muscle-invasive bladder cancer (MIBC).MethodsTRUCE-01 a single-arm phase 2 study that included 62 T2-4a N0/X M0 MIBC tumors predominant carcinoma histology. Eligible received three 21-d cycles intravenous 200 mg on day 1 plus 2,...
The mechanisms underlying the functional link between autophagy and plant innate immunity remain largely unknown. In this study, we investigated autophagy-mediated defense responses against Verticillium dahliae (V. dahliae) infection by comparative proteomics cellular analyses. An assessment of activity disease development showed that autophagic processes were tightly related to tolerance Arabidopsis wilt. isobaric tags for relative absolute quantification (iTRAQ)-based analysis was...
Abstract Anaplastic lymphoma kinase ( ALK ) fusions have been recognized as a therapeutic target in non‐small cell lung cancer NSCLC ). However, molecular signatures and clinical characteristics of the Chinese population with ‐rearranged are not well elucidated. In present study, we carried out targeted next‐generation sequencing on tissue plasma ct DNA samples 1688 patients . Overall, were detected 70 (4.1%), frequencies 5.1% 3.3%, respectively. Additionally, prevalence breakpoint locations...
The incidence of early stage multiple primary lung cancer (MPLC) has been increasing in recent years, while the ideal strategy for its diagnosis and treatment remains controversial. present study conducted genomic analysis to identify a new molecular classification method accurately predicting therapy patients with MPLC.A total 240 tissue samples from 203 multiple-non-small-cell cancers (NSCLCs) (n = 30), single-NSCLC (Group A, n 94), advanced-stage NSCLC B, 79) were subjected targeted...
ABSTRACT Background For early detection and postoperative monitoring of upper tract urothelial carcinoma (UTUC), the traditional method was limited to its invasiveness insufficient sensitivity. We aim use urine tumour DNA (utDNA) for detecting minimal residual disease (MRD), diagnosis perioperative in UTUC. Method previously established a utDNA multidimensional bioinformatic valuation model, named utLIFE, using low‐coverage whole‐genome sequencing targeted deep sequencing. This prospective...
Small bowel adenocarcinoma (SBA) is a rare malignancy with poor prognosis and limited treatment options. Despite prior studies, molecular characterization of this disease not well defined, little known regarding Chinese SBA patients. In study, we conducted multigene next-generation sequencing 16S ribosomal RNA gene on samples from 76 patients surgically resected primary SBA. Compared colorectal cancer Western cohorts, distinctive genomic profile was revealed in cohorts. According to the...
Abstract Background TP53 mutations are frequent in non‐small cell lung cancer (NSCLC). Different categories of may be associated with survival advanced NSCLC, but their effect on prognosis is diverse. To date, a comprehensive comparison the relationship between different classes alterations and NSCLC has rarely been performed. Moreover, prognostic significance novel approach called evolutionary action (EAp53) unclear. Methods A total 210 patients harboring mutation data were enrolled....
Osteosarcoma (OS) is a rare but aggressive malignancy. Despite previous reports, molecular characterization of this disease not well understood, and little known regarding OS in Chinese patients. Herein, we analyzed the genomic signatures 73 cases. TP53, NCOR1, LRP1B, ATRX, RB1, TFE3 were most frequently mutated gene our cohort. In addition, analysis Western patients was performed. Notably, there remarkable disparities mutational landscape, base substitution pattern, tumor burden between...
e16586 Background: Traditional methods for the detection and surveillance of non-muscle-invasive bladder cancer (NMIBC) were generally invasive, costly, not effective early-stage, low-grade, minimal residual disease (MRD) tumors. Whether urine tumor DNA could be used to early detect urothelial carcinoma monitor MRD with high sensitivity should explored. Methods: We conducted a perspective study determine performance utLIFE-UC (our previously reported multidimensional bioinformatic predictor)...
Occurrence at a young age is known to be associated with unique clinical features in colorectal cancer (CRC). However, the genomic differences between and old patients CRC are not well elucidated and, best of our knowledge, have never been investigated Chinese population.Tumor tissue samples from 29 (age ≤50 years) 46 >50 were collected. Targeted sequencing 808 cancer-related genes was conducted characterize landscape for CRC.Overall, mutational profiles exhibited notable two groups. In...
While tumor genotyping is the standard treatment for patients with non‑small cell lung cancer (NSCLC), spatial and temporal heterogeneity insufficient specimens can lead to limitations in use of tissue‑based sequencing. Circulating DNA (ctDNA) fully encompasses tumor‑specific sequence alterations offers an alternative tissue sample biopsies. However, few studies have evaluated whether frequency multiple genomic observed following ctDNA sequencing similar that NSCLC. Therefore, present study,...
In this report, we present a case study of 64-year-old female who was diagnosed with gastrointestinal stromal tumors (GISTs) and subsequently developed liver metastases despite undergoing radical resection. Next-generation sequencing (NGS) assays indicated that the tumor lacked KIT/PDGFRA/SDH/RAS-P (RAS pathways, RAS-P) mutations, thereby classifying patient as quadruple WT GIST (qGIST). Treatment imatinib initiated, after 2.5 months, recurrence multiple around surgical site were observed....
e20534 Background: While tumor genotyping is the standard treatment for patients with non-small cell lung cancer (NSCLC), spatial and temporal heterogeneity insufficient specimens can lead to limitations in use of tissue-based sequencing. Circulating DNA (ctDNA) fully encompasses tumor-specific sequence alterations offers an alternative tissue sample biopsies. The aim study was evaluate whether frequency multiple genomic observed following ctDNA sequencing similar that NSCLC. Methods: A...
Colorectal cancer (CRC) is one of the most prevalent malignances worldwide. However, CRC with situs inversus totalis (SCRC) extremely rare, and molecular characterization this disease has never been investigated. Tumor tissue samples from 8 patients SCRC 33 without (NSCRC) were subjected to multigene next-generation sequencing. The frequently mutated genes in APC, TP53, CHEK2, MDC1, GNAQ, KRAS, SMAD4. A high frequency tumors had mutations DNA damage repair genes. Single amino acid...
G1 and G2 colorectal neuroendocrine neoplasms (NENs) are a group of rare indolent diseases. We aimed to delineate their genetic characteristics explore metastatic mechanisms.