A5068656065- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Vitamin D Research Studies
- Urinary and Genital Oncology Studies
- Galectins and Cancer Biology
- Pelvic floor disorders treatments
- Cancer, Lipids, and Metabolism
- Urological Disorders and Treatments
- Cancer survivorship and care
- Urinary Bladder and Prostate Research
- Cancer Mechanisms and Therapy
- Signaling Pathways in Disease
- Immune cells in cancer
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- Hormonal and reproductive studies
- Patient-Provider Communication in Healthcare
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammatory Biomarkers in Disease Prognosis
- Pediatric Urology and Nephrology Studies
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
Chang Gung University
2015-2025
Chang Gung Memorial Hospital
2011-2025
Linkou Chang Gung Memorial Hospital
2022-2024
China Medical University Hospital
2024
China Medical University
2024
Taoyuan Chang Gung Memorial Hospital
2024
National Chung Shan Institute of Science and Technology
2013-2023
Keelung Chang Gung Memorial Hospital
2013-2022
University of Pangasinan
2020
Memorial Hospital of South Bend
2003-2014
Abstract Identification of potential factors that can stratify a tumor’s response to specific therapies will aid in the selection cancer therapy. The aim was highlight role programmed cell death 1 ligand (PD-L1) bladder cancer. In this study, 92 muscle-invasive cancers and 28 non- muscle invasive were selected for immunohistochemical staining analysis. Furthermore, human murine lines used examine correlation between PD-L1 radiation response. Our data revealed overexpressed tumor specimens...
Targeting androgens/androgen receptor (AR) functions via androgen deprivation therapy (ADT) remains the standard treatment for prostate cancer. However, most tumors eventually recur despite ADT. Here we demonstrate that AR may function as both a suppressor and proliferator to suppress or promote cancer metastasis. Results from orthotopically recombining stromal WPMY1 cells with epithelial PC3 in mice demonstrated restoring knockdown of suppressed Knockdown CWR22rv1 also resulted increased...
Developmental studies of the prostate have established that ductal morphogenesis, epithelial cytodifferentiation, and proliferation/apoptosis are regulated by androgens acting through stromal androgen receptor (AR). Here, we found mice lacking AR within mature (pes-ARKO) developed tissue was less differentiated hyperproliferative relative to WT littermates. Epithelial protein significantly decreased in 6-week-old nearly absent ≥24 weeks age. Circulating levels testosterone, external...
Hormone-resistant (HR) prostate cancers are highly aggressive and respond poorly to treatment. IL-6/STAT3 signaling has been identified link with the transition of HR tumor behavior. The role IL-6 in radiation response cancer was investigated present study.The murine cell line (TRAMP-C1) hormone-resistant sub-line, TRAMP-HR, were used assess using vitro clonogenic assays growth delay vivo. Biological changes following irradiation by means experimental manipulation signaling. Correlations...
Identification of potential tumor markers will help stratify and identify a tumor's malignant its response to specific therapies. IL-6 has been reported be predictor in various cancers. Therefore, the present study was performed highlight role improving treatment determining prognosis bladder cancer. The human cancer cell lines HT1376 HT1197 were selected for animal experiments, which biological changes after experimental manipulation explored, including behavior related signaling In...
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays important roles for prostate cancer cell survival, and the androgen receptor (AR) essential proliferation. How these two signals cooperate to control growth death, however, remains unclear debated. Here we provide first linkage by identification of Forkhead transcription factor FOXO3a, PI3K/Akt downstream substrate, as a positive regulator induction AR gene expression. Both Western blot real time PCR assays demonstrate that FOXO3a...
This two-part study with working adults examines which communication behaviors occur at work and how these are evaluated. Through an analysis of organizational publications (articles, case studies, textbooks), the authors identified 343 behaviors; sorting reduced this list to 163 verbal used in workplace. In Study 1, using online survey, 126 had been heard or observed previous day Forty-four were by 50% more participants, indicating their frequent use 2, 331 evaluated effectiveness on 44...
Abstract The aim of this study was to highlight the role 1α,25-dihydroxyvitamin D3 (calcitriol) in esophageal squamous cell carcinoma (SCC). human SCC lines CE81T and TE2 were selected for cellular animal experiments investigate changes tumor behavior after calcitriol supplementation underlying mechanisms. Moreover, we evaluated relationship between supplementation, myeloid-derived suppressor (MDSC) recruitment, IL6 levels, progression by a 4-nitroquinoline 1-oxide (4-NQO)–induced model. In...
// Chun-Te Wu 1,2 , Wei-Yu Lin 2,3 Ying-Hsu Chang 2,4 Paul-Yang 2,5 Wen-Cheng Chen 2,6 and Miao-Fen 1 Department of Urology, Gung Memorial Hospital at Keelung, Taiwan 2 University, College Medicine, Taoyuan City, 3 Chiayi, Puzi 4 Linko, 5 Pathology, 6 Radiation Oncology, Correspondence to: Chen, email: Keywords : bladder cancer, miR424, DNMT1, EGFR Received March 16, 2015 Accepted May 30, Published June 10, Abstract The aim this study was to examine the role miRNAs regulation by DNMT1 its...
Abstract Purpose: The majority of patients with prostate cancer who are treated androgen-deprivation therapy (ADT) will eventually develop fatal metastatic castration-resistant (mCRPC). Currently, there no effective durable therapies for mCRPC. High expression galectin-1 (Gal-1) is associated progression and poor clinical outcome. role Gal-1 in tumor largely unknown. Here, we characterized functions evaluated the therapeutic effects a newly developed inhibitor, LLS30, Experimental Design:...
Background Identification of potential factors that can stratify tumors' response to specific therapies will aid in the selection cancer therapy. Radioresistance is major obstacles positive outcomes bladder patients after definite chemotherapy. CD44, a stem cell surface marker, relevant treatment resistance. In present study, we examined role CD44 cancer. Methods We retrospectively analyzed clinical 85 treated with chemoradiotherapy, and correlated expressions IL-6 response. Furthermore,...
Early reports showed that androgen receptor (AR) NH2- and COOH-terminal (N-C) interaction was important for full AR function. However, the influence of these interactions on in vivo effects remains unclear. Here we tested some AR-associated peptides coregulators to determine their influences N-C interaction, transactivation, coregulator The results coactivators such as ARA70N, gelsolin, ARA54, SRC-1 can enhance transactivation but differential interaction. In contrast, corepressors ARA67...
Abstract BACKGROUND: The identification of potential tumor markers will help improve therapeutic planning and patient management. Therefore, the aim this study was to highlight role DNA methyltransferase 1 (DNMT1) in bladder cancer. METHODS: A total 50 samples nonmalignant urothelium, 65 muscle‐invasive cancers, 15 distant metastasis, nonmuscle‐invasive cancers were selected for immunohistochemical staining analysis. Furthermore, human cancer cell lines HT1376 HT1197 animal experiments...
Shikonin is a traditional Oriental medical herb extracted from Lithospermum erythrorhizon. Many studies have shown that shikonin possesses anticancer ability against many different cancers, including hepatocellular carcinoma (HCC). Recently, tumor metastasis has been become an important clinical obstacle. However, the effect of on by HCC unknown. The 50% inhibitory concentration (IC50) cells was determined MTT assay and xCELLigence biosensor system. migratory detected transwell migration...
Our study aimed to elucidate the role of Galectin-1 (Gal-1) in immunosuppressive tumor microenvironment (TME) prostate cancer (PCa). previous findings demonstrated a correlation between elevated Gal-1 expression and advanced PCa stages. In this study, we also observed that is expressed around stroma its level associated with progression. We identified could be secreted by cells, has potential induce T cell apoptosis. knockdown or inhibition function LLS30 suppresses apoptosis resulting...