Abstract Identification of potential factors that can stratify a tumor’s response to specific therapies will aid in the selection cancer therapy. The aim was highlight role programmed cell death 1 ligand (PD-L1) bladder cancer. In this study, 92 muscle-invasive cancers and 28 non- muscle invasive were selected for immunohistochemical staining analysis. Furthermore, human murine lines used examine correlation between PD-L1 radiation response. Our data revealed overexpressed tumor specimens...

Hormone-resistant (HR) prostate cancers are highly aggressive and respond poorly to treatment. IL-6/STAT3 signaling has been identified link with the transition of HR tumor behavior. The role IL-6 in radiation response cancer was investigated present study.The murine cell line (TRAMP-C1) hormone-resistant sub-line, TRAMP-HR, were used assess using vitro clonogenic assays growth delay vivo. Biological changes following irradiation by means experimental manipulation signaling. Correlations...

Identification of potential tumor markers will help stratify and identify a tumor's malignant its response to specific therapies. IL-6 has been reported be predictor in various cancers. Therefore, the present study was performed highlight role improving treatment determining prognosis bladder cancer. The human cancer cell lines HT1376 HT1197 were selected for animal experiments, which biological changes after experimental manipulation explored, including behavior related signaling In...

To assess the factors affecting incidence of radiation-induced dermatitis in breast cancer patients treated with adjuvant 3 D conformal radiotherapy by analysis dosimetry and topical treatments. Between September 2002 July 2009, 158 were after undergoing surgery. Before November 2006, 90 subjected to therapeutic skin care group corticosteroid therapy was used for acute radiation dermatitis. Thereafter, 68 received prophylactic from beginning radiotherapy. The two groups did not differ...

Oral squamous cell carcinoma (OSCC) is an aggressive head and neck cancer. Evidence showed that some pathogenic bacteria are associated with periodontitis oral The change in microbiome composition the role of specific periodontal pathogen Streptococcus mutans OSCC were investigated. We analyzed biofilms to identify if was OSCC. S. clinical prognosis for also examined. further examined infection progression preclinical experiments. assay by revealed there different microbiota between patients...

Abstract The aim of this study was to highlight the role 1α,25-dihydroxyvitamin D3 (calcitriol) in esophageal squamous cell carcinoma (SCC). human SCC lines CE81T and TE2 were selected for cellular animal experiments investigate changes tumor behavior after calcitriol supplementation underlying mechanisms. Moreover, we evaluated relationship between supplementation, myeloid-derived suppressor (MDSC) recruitment, IL6 levels, progression by a 4-nitroquinoline 1-oxide (4-NQO)–induced model. In...

Patients with oral cavity squamous cell carcinoma (OSCC) undergoing surgery are recommended to receive adjuvant radiation therapy or without chemotherapy if there unfavorable prognostic factors. A positive resection margin (PRM) and extra-capsular extension (ECE) of lymph nodes well-known major However, is no agreement on whether cancer patients should postoperative chemo-radiotherapy (CCRT) they present other risk factors a combination 2 more In this study, we investigated issue provide...

Laryngeal cancer accounts for 10% of head and neck cancers, with glottic cancers comprising two-thirds cases in our country [...].

Caffeic acid phenethyl ester (CAPE) is a biologically active ingredient of honeybee propoplis. The cytotoxicity and radiation sensitization effects CAPE were evaluated in human lung cancer A549 cells normal fibroblast WI-38 cells. treated with 6 μg/ml showed marked growth inhibition (60%) at 48 hr after treatments. During the same time, number viable decreased to 46% control value. In contrast, 20% no change under treatment conditions. At 72 (6 μg/ml), percentage apoptotic cultures increased...

// Chun-Te Wu 1,2 , Wei-Yu Lin 2,3 Ying-Hsu Chang 2,4 Paul-Yang 2,5 Wen-Cheng Chen 2,6 and Miao-Fen 1 Department of Urology, Gung Memorial Hospital at Keelung, Taiwan 2 University, College Medicine, Taoyuan City, 3 Chiayi, Puzi 4 Linko, 5 Pathology, 6 Radiation Oncology, Correspondence to: Chen, email: Keywords : bladder cancer, miR424, DNMT1, EGFR Received March 16, 2015 Accepted May 30, Published June 10, Abstract The aim this study was to examine the role miRNAs regulation by DNMT1 its...

Background Identification of potential factors that can stratify tumors' response to specific therapies will aid in the selection cancer therapy. Radioresistance is major obstacles positive outcomes bladder patients after definite chemotherapy. CD44, a stem cell surface marker, relevant treatment resistance. In present study, we examined role CD44 cancer. Methods We retrospectively analyzed clinical 85 treated with chemoradiotherapy, and correlated expressions IL-6 response. Furthermore,...

ABSTRACT Background The purpose of this study was to present our assessment the significance myeloid‐derived suppressor cells (MDSCs) in head and neck squamous cell carcinoma (HNSCC). Methods We examined percentage MDSCs peripheral blood patients with HNSCC. relationship among MDSC recruitment, tumor progression, cyclooxygenase (COX)‐2 inhibition also evaluated by animal models. Results Circulating were significantly increased HNSCC compared healthy people, associated clinical burden. In...

Abstract BACKGROUND: The identification of potential tumor markers will help improve therapeutic planning and patient management. Therefore, the aim this study was to highlight role DNA methyltransferase 1 (DNMT1) in bladder cancer. METHODS: A total 50 samples nonmalignant urothelium, 65 muscle‐invasive cancers, 15 distant metastasis, nonmuscle‐invasive cancers were selected for immunohistochemical staining analysis. Furthermore, human cancer cell lines HT1376 HT1197 animal experiments...

The aim of this study was to explore specific molecular markers that could lead new insights into the identification innovative treatments. role DNMT3b and its predictive power in prognosis oral cancer were identified. Human cell lines including SCC4 SCC25 selected for cellular experiments. Changes tumor growth, aggressiveness responsible signaling pathway investigated vitro vivo. Furthermore, 125 tissue specimens analyzed using immunohistochemical staining on microarray slides, correlations...

Abstract To assess if surgery provided survival benefit to patients with esophageal squamous cell carcinoma (SCC), we performed a retrospective review of 1230 who were newly diagnosed stage T2-T4 SCC from 2007 2014 in our hospital. There greater than 70% age under 65 years, and more 85% T3-T4 at the time diagnosis. The median was 1.06 year (95% CI 0.99–1.1 yrs). Survival analyses showed that significantly associated age, T stage, clinical lymph node involvement treatment modality (surgery...