A5023181868- Prostate Cancer Treatment and Research
- Dermatological diseases and infestations
- Prostate Cancer Diagnosis and Treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Urinary Tract Infections Management
- Pelvic floor disorders treatments
- Bladder and Urothelial Cancer Treatments
- Complementary and Alternative Medicine Studies
- Estrogen and related hormone effects
- Genital Health and Disease
- Urinary Bladder and Prostate Research
- Urinary and Genital Oncology Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Heavy Metal Exposure and Toxicity
- Cancer survivorship and care
- Urological Disorders and Treatments
- Brain Metastases and Treatment
- MicroRNA in disease regulation
- Maternal and Perinatal Health Interventions
- Pediatric Urology and Nephrology Studies
- Kidney Stones and Urolithiasis Treatments
- Acupuncture Treatment Research Studies
- Autophagy in Disease and Therapy
- Leptospirosis research and findings
- Pancreatic function and diabetes
Ministry of Health and Welfare
2016-2025
National Defense Medical Center
2017-2025
Tri-Service General Hospital
2017-2025
National Yang Ming University Hospital
2017-2020
National Yang Ming Chiao Tung University
2017-2020
Tao Yuan General Hospital
2015-2020
Ministry of Health and Welfare
2016-2020
Chang Gung Memorial Hospital
2012-2013
Linkou Chang Gung Memorial Hospital
2012
Chang Gung University
2011-2012
Biocompatible bacterial cellulose pellicle (BCP) is a candidate for biomedical material such as wound dressing. However, due to lack of antibacterial activity, grant BCP with the property crucial its application. In present study, was modified by 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-mediated oxidation using TEMPO/NaClO/NaBr system at pH 10 form TEMPO-oxidized (TOBCP) anionic C6 carboxylate groups. The TOBCP subsequently ion-exchanged in AgNO3 solution and silver nanoparticles...
Aberrant activation of the Ras/ERK pathway mediates breast cancer initiation and aggressiveness. Therefore, it is important to identify miRNAs that modulate during carcinogenesis progression. The Ras GTPase superfamily member RERG (Ras-related estrogen-regulated growth inhibitor) acts as a tumor suppressor reduce cell proliferation formation has been suggested have regulatory role in pathway. In this study, we found exerted its by attenuating signaling effectors. Furthermore, miR-382-5p...
Scabies is a common infectious disease and can cause severe outbreaks if not controlled quickly. Besides personal contact history, environmental factors are also important. This study analyzed the effects of climate on incidence scabies in Taiwan. We conducted 14-year nationwide population-based study: total 14,883 patients with infestation were enrolled. Monthly data collected from Taiwan's Central Weather Bureau, including temperature, relative humidity, rainfall, rain days, sunshine...
Paraquat (PQ), a toxic and nonselective bipyridyl herbicide, is one of the most extensively used pesticides in agricultural countries. In addition to pneumotoxicity, liver an important target organ for PQ poisoning humans. However, mechanism hepatotoxicity remains unclear. this study, we found that exposure rat hepatic H4IIE cells (0.1–2 mM) induced significant cytotoxicity apoptosis, which was accompanied by mitochondria-dependent apoptotic signals, including loss mitochondrial membrane...
Breast cancer-related mortality increases annually. The efficacy of current breast cancer treatments is limited, and they have numerous side effects permit high recurrence. Patients with estrogen receptor (ER)-negative or triple-negative are particularly difficult to treat. Treatment for this type lacking, its prognosis poor, necessitating the search alternative treatments.This study screened Chinese herb Hibiscus syriacus extracts identified a novel anti-cancer drug patients ER-negative...
Background: Multidrug resistance is a major obstacle in the successful therapy of breast cancer. Studies have proved that this kind drug happens both human cancers and cultured cancer cell lines. Understanding molecular mechanisms important for reasonable design use new treatment strategies to effectively confront cancers. Results: In our study, ATP-binding cassette sub-family G member 2 (ABCG2), adenosine triphosphate (ATP) synthase cytochrome c oxidase subunit VIc (COX6C) were...
Developing a multiple functional wound dressing suitable for different stages of healing is important patients with special such as burn or decubital ulcers. In this study, poly (vinyl alcohol) (PVA), dextran, and chitosan are integrated to produce ideal where glutaraldehyde (GA) used the cross-linker. The result demonstrated that 6% PVA hydrogel 0.25% was found provide antimicrobial ability. PVA/chitosan combined 4% dextran utilizing GA cross-linking also presents high cell proliferation...
Methylmercury (MeHg), a long-lasting organic pollutant, is known to induce cytotoxic effects in mammalian cells. Epidemiological studies have suggested that environmental exposure MeHg linked the development of diabetes mellitus (DM). The exact molecular mechanism MeHg-induced pancreatic β-cell cytotoxicity still unclear. Here, we found (1-4 μM) significantly decreased insulin secretion and cell viability β-cell-derived RIN-m5F A concomitant elevation mitochondrial-dependent apoptotic events...
The skin of Arachis hypogaea L. (peanut or groundnut) is a rich source polyphenols, which have been shown to exhibit wider spectrum noteworthy biological activities, including anticancer effects. However, the activity peanut extracts against melanoma and colorectal cancer (CRC) cells remains elusive. In this study, we systematically investigated cytotoxic, antiproliferative, pro-apoptotic, anti-migration effects ethanolic extract its fractions on CRC cells. Cell viability results showed that...
More than 50% of prostate cancer patients have used traditional Chinese medicine (TCM) in Taiwan. However, the long-term clinical efficacy TCM remains unclear. Here, we investigated relationship between use and survival patients. A retrospective nationwide cohort study was conducted 1998 2003 using Taiwan National Health Insurance Research Database. Patients were classified as users or nonusers, monitored from day diagnosis to death end 2012. The association risk determined Cox...
The prevalence of depression in patients with cancer is high, especially for advanced cancer. In this study, we evaluated the prostate Taiwan and association between mortality This study included 1101 newly diagnosed We tracked medical information these from diagnosis until end 2012. Patients were divided into two groups according to presence or absence diagnosis, further three stages by initial treatments: localized locally advanced, metastatic, castration-resistant Of participants, 267...
Tongue squamous cell carcinoma (SCC) is a most common type of oral cancer. Due to its highly invasive nature and poor survival rate, the development effective pharmacological therapeutic agents urgently required. Quercetin (3,3',4',5,7‑pentahydroxyflavone) polyphenolic flavonoid found in plants an active component Chinese herbal medicine. The present study investigated effects possible mechanisms quercetin on apoptosis tongue SCC‑derived SAS line. Following treatment with quercetin,...
Both periodontal disease (PD) and inflammatory bowel (IBD), including Crohn’s (CD) ulcerative colitis (UC), are important diseases of the alimentary tract. Microbiome immune-mediated processes play roles in these diseases. An association between PD IBD may exist. This study investigated risk patients with PD. used data from National Health Insurance Research Database Taiwan 1996 to 2013. A total 27,041 were enrolled as a group, 108,149 without selected control group after matching by gender,...