A5008614533- Autophagy in Disease and Therapy
- Shoulder and Clavicle Injuries
- Blood properties and coagulation
- Bone Tumor Diagnosis and Treatments
- FOXO transcription factor regulation
- NF-κB Signaling Pathways
- Metabolism, Diabetes, and Cancer
- Sirtuins and Resveratrol in Medicine
- Dermatology and Skin Diseases
- Pharmacological Effects of Natural Compounds
- Pelvic and Acetabular Injuries
- Neuroscience and Neuropharmacology Research
- Erythrocyte Function and Pathophysiology
- Adipose Tissue and Metabolism
- Caveolin-1 and cellular processes
- Psoriasis: Treatment and Pathogenesis
- Toxic Organic Pollutants Impact
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- Endoplasmic Reticulum Stress and Disease
Changhua Christian Hospital
2024-2025
Southern Medical University Shenzhen Hospital
2025
Affiliated Hospital of Guilin Medical College
2024
Soochow University
2024
Shantou University
2014
Shantou University Medical College
2014
The antidiabetic drug metformin exerts chemopreventive and antineoplastic effects in many types of malignancies. However, the mechanisms responsible for actions appear diverse may differ different cancer. Understanding molecular cellular specific cancers is important to optimize strategy treatment cancer types. Here, we investigate vitro vivo on esophageal squamous cell carcinoma (ESCC) cells. Metformin selectively inhibited growth ESCC tumor cells but not immortalized noncancerous...
BACKGROUND Liver hepatocellular carcinoma (LIHC) is a highly aggressive cancer with poor prognosis due to its complex tumor microenvironment (TME) and immune evasion. Regulatory T cells (Tregs) play critical role in progression. Suppressor of cytokine signaling 2 (SOCS2), key regulator, may modulate Treg activity impact LIHC growth metastasis. AIM To explore how the SOCS2 affects on METHODS transcriptome data from The Cancer Genome Atlas database were analyzed using Gene Set Enrichment...
<title>Abstract</title> <bold>Objective: </bold>Transsacral screws are commonly utilized in clinical settings for addressing vertical instability injuries of the posterior pelvic ring and fragility fractures elderly patients. Nevertheless, potential stenosis bone corridor resulting from dysmorphism upper sacral segment poses challenges insertion S1 through transsacral screw, increasing risk significant complications such as screw misalignment neurovascular injury. The purpose this study was...
ABSTRACT Epigenetic modifications play an important role in disturbed flow (d‐flow) induced atherosclerotic plaque formation. By analysing a scRNA‐seq dataset of the left carotid artery (LCA) under d‐flow conditions, we found that Jarid1b (KDM5B) was upregulated primarily subcluster endothelial cells response to stimulation. We therefore investigated mechanism KDM5B expression and cell. Intriguingly, activation Piezo1, major mechanosensor, promote expression, which reversed by Piezo1...