A5073215218- Cancer, Hypoxia, and Metabolism
- Cancer and Skin Lesions
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Hippo pathway signaling and YAP/TAZ
- Ear and Head Tumors
- Viral-associated cancers and disorders
- Endometrial and Cervical Cancer Treatments
- Pleural and Pulmonary Diseases
- Cytomegalovirus and herpesvirus research
- Head and Neck Surgical Oncology
- Pancreatic and Hepatic Oncology Research
- Thyroid Cancer Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Gastrointestinal disorders and treatments
- Tumors and Oncological Cases
- Cancer-related molecular mechanisms research
- BRCA gene mutations in cancer
- Colorectal and Anal Carcinomas
- Enzyme function and inhibition
- Head and Neck Anomalies
Chi Mei Medical Center
2015-2024
Kaohsiung Veterans General Hospital
2019-2024
Taipei Medical University
2007-2022
Kaohsiung Medical University
2021
Ministry of Health and Welfare
2021
Chung Hwa University of Medical Technology
2013-2015
Southern Taiwan University of Science and Technology
2007-2011
National Cheng Kung University Hospital
1993-2006
National Cheng Kung University
1996-2003
Tokyo Women's Medical University
1981
Rationale: Cancer cells reprogram cellular metabolism to fulfill their needs for rapid growth and metastasis. However, the mechanism controlling this reprogramming is poorly understood. We searched upregulated signaling in metastatic colorectal cancer investigated by which Glut3 promotes tumor Methods: compared RNA levels glycolytic capacity primary colon cancer. The expression association of with clinical prognosis tissues was determined immunohistochemistry. gain-of-function...
RON and MET belong to a subfamily of tyrosine kinase receptors. They both can induce invasive growth, including migration, cell dissociation, matrix invasion. Cross-linking experiments show that form noncovalent complex on the surface cooperate in intracellular signaling. We wanted examine clinical significance expression patterns node-negative breast cancer.We studied protein expressions five cancer lines homogeneous cohort 103 T(1-2)N(0)M(0) carcinoma patients, 52 patients with distant...
// Wen-Ying Lee 1, 2 , Wai-Theng 3 Chia-Hsiung Cheng 3, 4 Ku-Chung Chen Chih-Ming Chou Chu-Hung Chung 5 Min-Siou Sun Hung-Wei Meng-Ni Ho Cheng-Wei Lin 1 Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan School Medicine, College Taipei University, Taipei, Biochemistry and Molecular Cell Biology, Graduate Institute Sciences, Cellular Organismic Academia Sinica, Correspondence to: Lin, e-mail: cwlin@tmu.edu.tw Keywords: chlorpromazine, drug reposition, p53, apoptosis, SIRT1...
<i>Background:</i> To formulate individually tailored therapy for patients with early-stage breast cancer, it is necessary to identify biomarkers predicting metastasis and survival. <i>Methods:</i> A homogeneous cohort of 92 T1-2N0M0 carcinoma a long-term follow-up were divided into two groups: the group (n = 41) disease-free 51). We evaluated ability risk discrimination six biomarkers, including S100A4, <i>Met</i>, bcl-2, p53, survivin, HER-2/neu, in...
Mutation of KRAS in non‐small‐cell lung cancer (NSCLC) shows a poor response to epidermal growth factor receptor (EGFR) inhibitors and chemotherapy. Currently, there are no direct anti‐KRAS therapies available. Thus, new strategies have emerged for targeting downstream signaling. Panobinostat is clinically available histone deacetylase inhibitor treating myelomas also potentiality NSCLC. However, the therapeutic efficacy panobinostat against gefitinib‐resistant NSCLC unclear. In this study,...
Background Nasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV). The metastasis to cervical lymph nodes represents a frequent initial manifestation of NPC. usefulness EBV detection by polymerase chain reaction (PCR) in the diagnosis occult NPC has been reported. Our previous study showed that EBER1 in-situ hybridization was somewhat more sensitive and specific than PCR detecting evaluation specimens from population at high risk for Methods Fine-needle...
Phellinus linteus (PL) is a medicinal mushroom due to its several biological properties, including anticancer activity. However, the mechanisms of effect remain be elucidated. We evaluated inhibitory effects ethanolic extract from PL combined with 5-FU on MDA-MB-231 breast cancer cell line and determine mechanism death. Individually, significantly inhibited proliferation cells in dose-dependent manner. (30 mg/mL) combination (10 μg/mL) synergistically by 1.8-fold. did not induce apoptosis,...
The tumor microenvironment plays an important role in initiation and progression. It is well documented that nicotine participates cigarette smoking‐related malignancies. Previous studies focused on the effects of cells; however, nicotine‐mediated tumorigenesis poorly understood. Herein, we investigated effect molecular mechanism fibroblasts its contribution to breast cancer. We found induced epithelial‐mesenchymal transition (EMT) cancer cells promoted activation fibroblasts. Interestingly,...
Abstract The cellular function of electroneutral K‐Cl cotransport (KCC) is to regulate epithelial ion transport and osmotic homeostasis. Here we investigate the mechanisms by which insulin‐like growth factor 1 (IGF‐1) cooperates with KCC modulate breast cancer biology. IGF‐1 stimulates activity MCF‐7 cells in a dose‐ time‐dependent manner. Increased KCC3 KCC4 abundances contribute IGF‐1‐enhanced activity. Endogenous invasiveness was modestly attenuated KCC4‐specific siRNA residual much less...
Abstract Genistein, one of the major isoflavones, potently inhibits growth and metastasis breast cancer. However, precise molecular mechanism in inhibition is not clear. We investigated effect genistein HCC1395 cells, a cell line derived from an early-stage primary Genistein dose dependently both decreased viability inhibited invasion potential. used human oligonucleotide microarrays to determine gene expression profile altered by treatment. TFPI-2, ATF3, DNMT1, MTCBP-1, which inhibit...
Triple-negative breast cancer (TNBC) is the most malignant subtype of as it shows a high capacity for metastasis and poor prognoses. Metabolic reprogramming one hallmarks cancer, aberrant glycolysis was reported to be upregulated in TNBC. Thus, identifying metabolic biomarkers diagnoses investigating cross-talk between invasiveness could potentially enable development therapeutics patients with In order determine novel reliable predicting clinical outcomes TNBC, we analyzed transcriptome...
Spontaneous or expressible nipple discharge may occur in palpable and nonpalpable breast lesions. The aim of the study was to evaluate sensitivity specificity cytology One hundred seventy‐four specimens were reviewed, which 82 had corresponding surgical pathology, including 34 lesions 48 There good correlation between concomitant fine needle aspiration (FNA) cytology. Nipple is as specific FNA but slightly less sensitive detecting papillomas malignant similar. very helpful an underlying...
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