A5044188919- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Bladder and Urothelial Cancer Treatments
- Liver physiology and pathology
- PARP inhibition in cancer therapy
- Lipid metabolism and biosynthesis
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Inflammatory mediators and NSAID effects
- Organ Transplantation Techniques and Outcomes
- Pelvic floor disorders treatments
- Urinary and Genital Oncology Studies
- Cancer Genomics and Diagnostics
- Lipoproteins and Cardiovascular Health
- Cancer Mechanisms and Therapy
- Hormonal and reproductive studies
- Ovarian cancer diagnosis and treatment
- Regulation of Appetite and Obesity
- Cholesterol and Lipid Metabolism
China Medical University
2016-2025
China Medical University Hospital
2016-2025
Asia University
2016-2024
China Medical University
2012-2023
Nanjing Medical University
2018
Post Graduate Medical Institute
2013-2014
University of Rochester Medical Center
2007-2014
Henan University Huaihe Hospital and Huaihe Clinical Institute
2014
National Taichung University of Science and Technology
2014
National Yang Ming Chiao Tung University
2012
Early studies demonstrated that whole-body androgen receptor (AR)–knockout mice with hypogonadism exhibit insulin resistance. However, details about the mechanisms underlying how androgen/AR signaling regulates sensitivity in individual organs remain unclear. We therefore generated hepatic AR-knockout (H-AR−/y) and found male H-AR−/y mice, but not female H-AR−/− fed a high-fat diet developed steatosis resistance, aging chow exhibited moderate steatosis. hypothesized increased obese resulted...
Targeting androgen receptor may prevent hepatitis B virus–induced liver cancer.
Early reports suggested androgen/androgen receptor (AR) signals promote hepatocarcinogenesis. However, all antiandrogen clinical trials failed in advanced hepatocellular carcinoma (HCC) without reasonable explanations. We examined AR functions HCC cancer metastasis this study. hepatic roles by comparing liver hepatocyte knockout and wildtype a carcinogen-induced mouse model. tumor histology, metastatic risks, survival vivo , as well cell anoikis migration using primary culture vitro . also...
Abstract With the continuing rise of lipidomic studies, there is an urgent need for a useful and comprehensive tool to facilitate data analysis. The most important features making lipids different from general metabolites are their various characteristics, including lipid classes, double bonds, chain lengths, etc. Based on these species can be classified into categories and, more interestingly, exert specific biological functions in group. In effort simplify analysis workflows enhance...
Smad proteins have been demonstrated to be key components in the transforming growth factor β signaling cascade. Here we demonstrate that Smad4, together with Smad3, can interact androgen receptor (AR) DNA-binding and ligand-binding domains, which may result modulation of 5α-dihydrotestosterone-induced AR transactivation. Interestingly, prostate PC3 LNCaP cells, addition Smad3 enhance transactivation, co-transfection Smad4 then repress transactivation various response element-promoter...
Abstract Transplantation of bone marrow mesenchymal stem cells (BM-MSCs) has been considered as an alternative therapy, replacing liver transplantation in clinical trials, to treat cirrhosis, irreversible disease that may eventually lead cancer development. However, low survival rate the BM-MSCs leading unsatisfactory efficacy remains a major concern. Gender differences have suggested therapeutic application, but effect androgen receptor (AR), key factor male sexual phenotype, this...
Abstract Gender disparity has long been considered as a key to fully understand hepatocellular carcinoma (HCC) development. At the same time, immunotherapy related IL12 still need more investigation before being applied in clinical settings. The aim of this study is investigate influence androgen receptor (AR) on natural killer (NK) cell–related innate immune surveillance liver cancer, and provide novel therapeutic approach suppress HCC via altering IL12A. By using vitro cell cytotoxicity...
Gastric cancer (GCa) is a malignancy with few effective treatments. Ursolic acid (UA), bioactive triterpenoid enriched in Hedyotis diffusa Willd, known to suppress GCa without identified target. CYP19A1 (cytochrome P450 family 19A1; also as aromatase, Ar) was correlated prognosis. Relatedly, Ar silencers, which halt the expression of exhibited anti-GCa effects experimental models, are currently being investigated.The docking simulation score UA compared inhibitors, e.g., letrozole,...
Background: Sleep difficulty is common in the current society. Poor sleep has a significant influence on health, social interactions and even mortality; therefore, maintaining good of prime importance. Cannabidiol (CBD), cannabis-derived compound, known for its medical significance with many positive effects humans, including decreasing anxiety improving those disorders. Objective: However, whether CBD skin absorption results similar unknown. Therefore, examining CBD-coated fabric as pillow...
Abstract Introduction Resistance of cancer stem/progenitor cells (CSPCs) to chemotherapy can lead relapse. Ovarian teratocarcinoma (OVTC) arises from germ and comprises pluripotent that be used study cell stemness. In this study, we evaluated whether microRNA-21 (miR-21) promotes ovarian by maintaining populations. Methods The lentiviral delivery system was upregulate or suppress the expression miR-21 in human line PA1 growth assays were monitor at different time points. Antibodies directed...
Background and Aims: Improving liver regeneration (LR) capacity thereby function reserve is a critical bridging strategy for managing failure patients. Since estrogen signaling may participate in LR, our aim was to characterize the roles of ERα ERβ LR. Methods: LR estradiol levels following 2/3rd partial hepatectomy (PHx) were compared ERα-KO or ERβ-KO vs. wildtype mice. The ERα- ERβ-related transcriptome interactome analyzed from regenerating livers, then bioinformatics used pathway...
// Wei-Chun Chang 1, 2 , Shang-Fen Huang 1 Yang-Ming Lee 2, 3 Hsueh-Chou Lai Bi-Hua Cheng 4 Wei-Chung Jason Yen-Ping Ho Long-Bin Jeng Wen-Lung Ma 5 Sex Hormone Research Center, Department of Obstetrics and Gynecology, Gastroenterology, Center for Tumor Medical Science, Organ Transplantation China University/Hospital, Taichung, Taiwan Graduate Institute Biomedical Sciences/Clinical School Medicine, University, Endocrinology Metabolism, Changhua Christian Hospital, Changhua, OBs& GYN,...
Abstract Subjects with metabolic syndrome (MetS) commonly have atrial remodeling, which indicates a risk for fibrillation. This study determined MetS-related changes in lipid components very-low-density lipoprotein (VLDL), has been shown to cause the effect of statins on these changes, and correlation between remodeling VLDL compositions. Blood samples were collected from 12 non-MetS 27 sex- age-matched MetS subjects. Fourteen patients (MetS-off statin) discontinued statin therapy 14 days...
Abstract Current knowledge regarding mechanisms of carcinogenesis in human beings centres around the accumulation genetic instability, amplified cellular signalling, disturbed energy metabolism and microenvironmental regulation governed by complicated cell–cell interactions. In this article, we provide an alternative view cancer biology. We propose that behaves as a systemic dictator interacts with tissues throughout body to control their eventually homeostasis. The mechanism development...
Epithelial ovarian cancer (EOC) is one of the most lethal gynecological malignancies and presents chemoresistance after chemotherapy treatment. Androgen receptor (AR) has been known to participate in proliferation. Yet mechanisms resistance this drug its linkage AR remains unclear.To elucidate AR-related paclitaxel sensitivity, co-IP, luciferase reporter assay ChIP were performed identify that direct-regulated ABCG2 expression under IHC staining by antibody presented higher serous-type...