A5026689418- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Epigenetics and DNA Methylation
- Urinary Bladder and Prostate Research
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Phytoestrogen effects and research
- Urologic and reproductive health conditions
- Renal and Vascular Pathologies
- Renal and related cancers
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Sarcoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Urinary and Genital Oncology Studies
- Macrophage Migration Inhibitory Factor
- Protein Degradation and Inhibitors
- Glutathione Transferases and Polymorphisms
- TGF-β signaling in diseases
- Genomics, phytochemicals, and oxidative stress
- Pediatric Urology and Nephrology Studies
Tianjin Medical University
2011-2024
Second Hospital of Tianjin Medical University
2011-2024
Nankai University
2007
Yanbian University Hospital
2006
Chungbuk National University
2005-2006
Yanbian University
2005
Abstract RUNX3 is inactivated at high frequency in many tumors. However, most cases, inactivation caused by silencing of the gene due to promoter hypermethylation. Because epigenetic known affect major tumor suppressor genes cancer cells, it not clear whether primarily responsible for induction carcinogenesis these except gastric cases that we reported previously. We investigated genetic and alterations 124 bladder seven tumor–derived cell lines. Here show aberrant DNA methylation 73% (90...
No AccessJournal of UrologyInvestigative urology1 Apr 2006Enhanced Expression Peroxiredoxin I and VI Correlates with Development, Recurrence Progression Human Bladder Cancer Changyi Quan, Eun-Jong Cha, Hyung-Lae Lee, Kwang Hee Han, Keon Myung Wun-Jae Kim QuanChangyi Quan Department Urology, Yanbian University Hospital, Yanji, People's Republic China , ChaEun-Jong Cha Biomedical Engineering, Chungbuk National University, Cheongju, South Korea LeeHyung-Lae Lee HanKwang Han LeeKeon College...
Acetylation of chromatin interacting proteins is central to the epigenetic regulation gene expression. Various tumor suppressors are inactivated by abnormal modification. A great deal effort has been devoted developing anticancer agents that reactivate silenced modulating structure. Studies show histone deacetylase inhibitors can act as and several currently in clinical trials. We noted suppressor RUNX3 promoter hypermethylation human bladder cancer. investigated whether reactivation could...
Abstract Matrix Metalloproteinases (MMPs) have been demonstrated to be essential in facilitating the migration and metastasis of clear cell renal carcinoma (ccRCC). However, ability MMP family predict clinical outcomes guide optimal therapeutic strategies for ccRCC patients remains incompletely understood. In this investigation, we initially conducted a thorough examination pan-cancer. Notably, MMPs exhibited distinctive significance ccRCC. Following this, undertook an extensive analysis...
Abstract Enabled resistance or innate insensitiveness to antiandrogen are lethal for castration-resistant prostate cancer (CRPC). Unfortunately, there seems be little can done overcome the because of largely unknown mechanisms. In prospective cohort study, we found that HOXB3 protein level was an independent risk factor PSA progression and death in patients with metastatic CRPC. vivo, upregulated contributed CRPC xenografts abiraterone resistance. To uncover mechanism driving tumor...
Laparoscopic Madigan prostatectomy have not been reported yet. We modified the to make it suitable for laparoscopically enucleating hyperplastic glands larger than 100 g.Between May 2007 and Oct 2008, extraperitoneal laparoscopic with maintenance of intact urethra had performed on 16 patients benign prostatic hyperplasia (BPH) mg. To use, two major modifications made: (1) Open prostate capsule near bladder neck without sutures along opening; (2) identify mucosa before recognizing urethra....
As deregulation of androgen receptor (AR) signaling target genes is associated with tumorigenesis and the development prostate cancer (PCa), AR primary therapeutic for PCa. Although patients initially responses to first-line deprivation therapies (ADTs), most them advanced PCa progress lethal castration-resistant (CRPC). Recent studies have suggested molecular mechanisms by which elicit robust up-regulation FKBP51 gene. We suggest that restored expression gene, modulated splicing variant 7...
Previous study has reported that loss of epithelial androgen receptor (AR) may promote tumor progression and cause TRAMP mouse model die earlier. The detail mechanisms, however, remain unclear.Immunohistochemistry assay, Western blot real-time PCR were used to detect the expression mesenchymal markers. RNA extraction, RT-PCR, quantitative BrdU incorporation assays, flow cytometry other experimental technics also in present work.Decreased markers (Cytokeratin 8, NKX3.1 E-cadherin) increased...
Upper tract urothelial carcinoma (UTUC) is a rare and highly malignant tumor originating from the renal pelvis ureter associated with poor prognosis. It has been established that 70% of ureteral tumors occur in lower ureter. Radical nephroureterectomy (RNU) ipsilateral bladder cuff excision regarded as standard treatment for UTUC. Current evidence supports role lymph node dissection (LND) determining staging, but no consensus reached on potential survival benefits. The present study...
Background: Periodontitis and benign prostatic hyperplasia (BPH) are all common chronic diseases with higher incidence in middle-aged old men. Several studies have indicated a potential association between periodontitis BPH, although the findings remain inconclusive. However, there is no mendelian randomization (MR) to assess this association. Methods: The 40 men who had received health check-ups were included an epidemiological study. Genetic data of BPH (13118 cases 72799 controls) (3046...
Abstract Background The six‐transmembrane epithelial antigen of the prostate 3 (STEAP3) is a metalloreductase, which essential for iron uptake. Existing literature has shown that STEAP3 may perform an important role in onset and progression tumors. Nonetheless, complete pan‐cancer investigation prognostic significance immune properties currently unavailable. Aims As part our into possible functions malignancies, we conducted comprehensive analysis to examine value features human pan‐cancer....
To optimise the diagnosis and treatment of primary renal leiomyosarcoma, we present our experience with a similar case review literature.A 49-year woman was incidentally found to have palpable mass in right kidney.CT scan revealed an enhancing, heterogeneous, 6×7×9 cm mass.On suspicion carcinoma, radical nephrectomy performed.The pathological leiomyosarcoma.After 40 months regular follow-up, local recurrence found, she had liver metastases.She died cachexia due tumor metastasis, survival...