A5088535705- Cancer-related gene regulation
- Building Energy and Comfort Optimization
- Global Cancer Incidence and Screening
- Quinazolinone synthesis and applications
- Refrigeration and Air Conditioning Technologies
- Phytoestrogen effects and research
- Wastewater Treatment and Nitrogen Removal
- Inflammatory mediators and NSAID effects
- CRISPR and Genetic Engineering
- Synthesis and Characterization of Heterocyclic Compounds
- Cervical Cancer and HPV Research
- Engineering Applied Research
- Pomegranate: compositions and health benefits
- Antioxidant Activity and Oxidative Stress
- Cardiac Fibrosis and Remodeling
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Infection Control and Ventilation
- Ubiquitin and proteasome pathways
- Water Quality Monitoring and Analysis
- Color perception and design
- Water Quality Monitoring Technologies
- PI3K/AKT/mTOR signaling in cancer
- Digestive system and related health
- Protein Tyrosine Phosphatases
University of Florida
2024-2025
Ningbo University
2025
Harbin Medical University
2017-2018
Ovarian cancer is the third most common in female reproductive organs and epithelial ovarian has highest lethality of all gynecological cancers. Pomegranate fruit juice (PFJ) been shown to inhibit growth several types other than cancer. In this study, we exposed cell line A2780 PFJ two its components (ellagic acid luteolin). MTT wound healing assays demonstrated that three treatments suppressed proliferation migration cells. addition, western blotting ELISA showed expression levels MMP2 MMP9...
Ovarian cancer is one of the three leading gynecological malignancies, characterized by insidious growth, highly frequent metastasis, and quick development drug resistance. As a result, this disease has low 5-year survival rates. Estrogen receptor inhibitors were commonly used for treatment, but only 7% to 18% patients respond anti-estrogen therapies. Therefore, more effective therapies inhibit estrogen-related tumors are urgently needed. Recently, phytoestrogens, such as lignans with...
Protein arginine methyltransferase 5 (PRMT5), which symmetrically dimethylates cytosolic and nuclear proteins, has been demonstrated as an important cancer therapeutic target. In recent years, many advanced achievements in PRMT5 inhibitor development have made. Most inhibitors the clinical trial focus on targeting C-terminal catalytic domain, whereas developing small molecules to interrupt PRMT5/pICLn (methylosome subunit) protein–protein interface is also of great importance for inhibiting...
This study proposes a flow field modeling analysis of kitchen environments with air-conditioning range hoods. The substructure approach is applied to resolve the challenges low computational efficiency and convergence difficulties associated simultaneous consideration hood cooling fan impeller rotation models. presented effectively enhances while ensuring accuracy. A was performed in Fluent obtain velocity contour plot at outlet monitoring surface. data were then mapped full model enable...
High energy consumption and low aeration efficiency remain significant challenges in wastewater treatment. This study introduces a computational method that integrates the activated sludge model with Fluent (2021) to comprehensively simulate internal operations of tanks, enabling accurate modeling biochemical mass transfer processes. Hydraulic retention times were analyzed using streamlined patterns, while low-velocity flow regions identified across cross-sectional planes. The systematically...
Background/Aims: Cardiac interstitial fibrosis is an abnormality of various cardiovascular diseases, including myocardial infarction, hypertrophy, and atrial fibrillation, it can ultimately lead to heart failure. However, there a lack practical therapeutic approaches treat reverse the damage heart. The purpose this study was investigate effect long-term aspirin administration on pressure overload–induced cardiac in mice reveal underlying mechanisms treatment. Methods: C57BL/6 were subjected...
DNA polymerase β (Polβ) is crucial for the base excision repair (BER) pathway of damage and an attractive target suppressing tumorigenesis as well chemotherapeutic intervention cancer. In this study, a unique strategy scaffold-hopping-based molecular editing bioactive agent
A series of compounds were designed utilizing molecular modeling and fragment-based design based upon the known protein phosphatase 2A (PP2A) activators,