A5100438380- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Cancer-related Molecular Pathways
- Pharmacogenetics and Drug Metabolism
- Ferroptosis and cancer prognosis
- interferon and immune responses
- Respiratory Support and Mechanisms
- Retinoids in leukemia and cellular processes
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug Transport and Resistance Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Nosocomial Infections in ICU
- Cardiac Structural Anomalies and Repair
- Colorectal Cancer Treatments and Studies
- Extracellular vesicles in disease
- Bioinformatics and Genomic Networks
- Cytokine Signaling Pathways and Interactions
- PARP inhibition in cancer therapy
- Drug-Induced Adverse Reactions
- Colorectal and Anal Carcinomas
Naval University of Engineering
2025
Union Hospital
2024
Huazhong University of Science and Technology
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Third Affiliated Hospital of Harbin Medical University
2019-2023
Medscape
2023
Harbin Medical University
2018-2023
Hebei Medical University
2023
Second Hospital of Hebei Medical University
2023
Jiangsu University
2023
Small nuclear power reactors have small core dimensions, frequent changes, and more severe distortion compared to stations. However, their has fewer measurement points, making it difficult observe distribution. High-precision physical calculation programs can accurately calculate the distribution, but real-time performance of is poor, which not conducive online use. In this study, based on computing programs, distribution spectrum library under different operating conditions calculated,...
<h3>BACKGROUND:</h3> Lung ultrasound is a valuable imaging tool in the diagnosis of community-acquired pneumonia. However, its diagnostic accuracy ventilator-associated pneumonia (VAP) has not been fully investigated. The aim this study was to evaluate performance combination lung with procalcitonin (PCT) mechanically ventilated subjects symptoms suggestive <h3>METHODS:</h3> A prospective 124 suspected VAP 2 multidisciplinary ICUs conducted between December 2016 and October 2017. Lower...
Abstract Aberrant expression or mutation of the Septin gene family is closely associated with cancer progression, and septin 2 (SEPT2) exerts its tumor‐promoting effects in multiple cancers, but role regulating laryngeal squamous cell carcinoma (LSCC) progression drug resistance has not been investigated. Based on published data, present study identified that SEPT2 promoted increased cisplatin‐resistance LSCC, a novel LncRNA FGD5‐AS1/miR‐497‐5p axis was crucial for this process....
Background: Immune checkpoint inhibitors (ICIs), including anti-PD-1, anti-PD-L1 and anti-CTLA-4 antibodies, have become a standard treatment for multiple cancer types. However, ICIs can induce immune-related adverse events, with hepatitis-related events (HRAEs) being of particular concern. Our objective is to identify characterize HRAEs that exhibit significant association using real-world data. Methods: In this observational retrospective pharmacovigilance study, we extracted reports from...
Abstract Head and neck squamous cell carcinoma (HNSCC) is a common cancer with high mortality. Anilin actin-binding protein (ANLN) has been reported to be associated carcinogenesis in multiple tumors. However, the expression pattern functional effects of ANLN HNSCC remain unclear. Clinical data online databases were used analyze its relationship patient survival. Expression two major splice variants was assessed tissues lines. The related mechanisms isoforms investigated vitro vivo. Our...
It has been recognized that depth of invasion (DOI) is closely associated with patient survival for most types cancer. The purpose this study was to determine the DOI optimal cutoff value and its prognostic in laryngeal squamous carcinoma (LSCC). Most importantly, we evaluated performance five candidate modified T-classification models patients LSCC. LSCC from Harbin Medical University Cancer Hospital Chinese Academy Sciences were divided into training group (n = 412) validation 147)....
Myasthenia gravis (MG) is an autoimmune disease and the most common type of neuromuscular disease. Genes miRNAs associated with MG have been widely studied; however, molecular mechanisms transcription factors (TFs) relationship among them remain unclear. A TF-miRNA-gene network (TMGN) was constructed by extracting six regulatory pairs (TF-miRNA, miRNA-gene, TF-gene, miRNA-TF, gene-gene miRNA-miRNA). Then, 3/4/5-node motifs were detected in TMGN. highest Z-score, occurring as composite...
Colorectal cancer (CRC) is a heterogeneous disease and one of the most prevalent malignancies worldwide. Previous research has demonstrated that mitophagy crucial to developing colorectal cancer. This study aims examine association between mitophagy-related genes prognosis CRC patients. Gene expression profiles clinical information patients were obtained from The Cancer Genome Atlas (TCGA) Expression Omnibus (GEO) databases. Univariate Cox regression least absolute shrinkage selection...
We built a joint replacement loosening model based on the original rabbit of infection and evaluated performance characteristics 18F-FDG 68 Ga-FAPI in evaluating loosening.After surgery, rabbits were divided into four groups, with six individuals control group 10 each aseptic loosening, S. aureus epidermidis groups. PET/CT serological examination performed three times at two-week intervals. After euthanized, micro-CT, tissue pathology, pullout tests scanning electron microscopy (SEM)...
The development of an effective therapeutic intervention for liver cancer is a worldwide challenge that remains to be adequately addressed. Of note, <em>TP53</em>, which encodes the p53 protein, important tumor suppressor gene, 61% <em>TP53</em> functionally inactivated in cancer. Recombinant human adenovirus (rAd‑p53) first commercial product has been used gene therapy. In present study, combined mechanistic effects rAd‑p53 and curcumin, naturally occurring compound with previously reported...
Long noncoding RNAs (lncRNAs) have multiple functions with regard to the cancer immunity response and tumor microenvironment. The prognosis of head neck squamous cell carcinoma (HNSCC) is still poor currently, it may be effective predict clinical outcome immunotherapeutic HNSCC by immunogenic analysis. Therefore, using univariate COX analysis Lasso Cox regression, we identified a signature consisting 21 immune-related lncRNA pairs (IRLPs) that predicted Immunotherapeutic in HNSCC....
The aim was to build a predictive model based on ultrasonography (US)-based deep learning (US-DLM) and clinical features (Clin) for differentiating hepatocellular carcinoma (HCC) from other malignancy (OM) in cirrhotic patients. 112 patients with 120 HCCs 60 61 OMs were included. They randomly divided into training test cohorts 4:1 ratio developing evaluating US-DLM model, respectively. Significant Clin predictors of OM the cohort combined nomogram (US-DLM+Clin). diagnostic performance...
The morbidity of thyroid carcinoma has been rising worldwide and increasing faster than any other cancer type. most common subtype with the best prognosis is papillary (PTC); however, exact molecular pathogenesis PTC still not completely understood.In current study, 3 gene expression datasets (GSE3678, GSE3467, GSE33630) 2 miRNA (GSE113629 GSE73182) were selected from Gene Expression Omnibus (GEO) database further used to identify differentially expressed genes (DEGs) deregulated miRNAs...
Five members of the zinc finger cerebellum (ZIC) family-ZIC1, ZIC2, ZIC3, ZIC4, and ZIC5-have been shown to be involved in various carcinomas. Here, we aimed explore clinicopathologic prognostic roles ZIC family invasive breast cancer patients using immunohistochemical analysis, western blotting real-time quantitative polymerase chain reaction (RT-qPCR).A total 241 female who underwent radical mastectomy between 2009 2011 were enrolled. proteins pairs tumors corresponding normal tissues...
Abstract Context Accumulated evidence indicates that geniposide exhibits neuroprotective effects in ischemic stroke. However, the potential targets of remain unclear. Objective We explore Materials and methods Adult male C57BL/6 mice were subjected to middle cerebral artery occlusion (MCAO) model. Mice randomly divided into five groups: Sham, MCAO, geniposide-treated (i.p. twice daily for 3 days before MCAO) at doses 25, 75, or 150 mg/kg. first examined geniposide. Then, we further explored...
Aims: To investigate the prognostic relevance of platelet volume indices for survival in laryngeal cancer. Patients & methods: The study included 640 patients with We analyzed optimal cutoff values through receiver operating characteristic analysis, then univariate factor and multivariate variables. Kaplan-Meier curves log-rank tests were conducted to compare overall (OS) recurrence-free rates between groups. Results: In elevated distribution width (PDW) PDW/platelet count ratio...
The aim is to estimate the prognostic value of lactate dehydrogenase (LDH) in patients undergoing surgical resection for laryngeal squamous cell carcinoma (LSCC). A total 640 resected LSCC were included. Preoperative was assessed. Kaplan-Meier survival analysis and Cox regression conducted overall (OS) recurrence-free (RFS). analysis, univariate multivariate demonstrated significant preoperative LDH. Although LDH predictor OS, it failed be a RFS. HR 95% CI 0.484 0.357-0.658 (P < 0.0001)....