A5101638650- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Head and Neck Cancer Studies
- Thyroid Cancer Diagnosis and Treatment
- Extracellular vesicles in disease
- RNA Research and Splicing
- Thyroid Disorders and Treatments
- Cancer-related Molecular Pathways
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- Radiation Dose and Imaging
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Genetic and Kidney Cyst Diseases
- Fibroblast Growth Factor Research
- Neuroscience and Neural Engineering
- Cell death mechanisms and regulation
- Cancer Mechanisms and Therapy
- Nanoplatforms for cancer theranostics
- Prostate Cancer Treatment and Research
First Hospital of China Medical University
2025
China Medical University
2025
Harbin Medical University
2011-2023
Third Affiliated Hospital of Harbin Medical University
2011-2023
Fudan University
2008-2021
Affiliated Hospital of North Sichuan Medical College
2020
Shanghai University of Medicine and Health Sciences
2018
State Key Laboratory of Medical Neurobiology
2008
Abstract Laryngeal squamous cell carcinoma (LSCC) is a highly malignant tumor originated from respiratory system. Although there have been many improvements in therapy until now, reducing the high mortality remains difficult. Understanding cellular heterogeneity of LSCC could contribute to improve this problem. Single‐cell RNA sequencing was applied dissect composition and molecular characteristics tissues. Immunohistochemistry staining tissues performed identify spatial location cells....
A family of small non-coding RNAs, ~22 nt in length, known as microRNAs (miRNAs), regulating ~30% all human gene expression, have been reported to be involved the pathogenesis a number types cancers, including laryngeal squamous cell carcinoma (LSCC). In current study, miR-34a and miR-34c were observed downregulated LSCC tissues. Ectopic expression Hep-2 cells significantly induced proliferation migration ability vitro....
Abstract AFAP1‐AS1 is a long non‐coding RNA that associated with tumorigenesis and poor prognosis in variety of cancers. We have been suggested increases laryngeal carcinoma specifically by enhancing stemness chemoresistance. assessed expression human specimens, paired adjacent normal tissues HEp‐2 cells. Indeed, we found not only was up‐regulated specimens cells, but also stemness‐associated genes were overexpressed. Silencing promoted cell chemoresistance under cisplatin treatment....
High incidences of laryngeal cancer have been reported recently. Increasing our understanding the molecular mechanisms underlying this malignancy could reveal more effective approaches to treating patients and so improve their prognoses. In study, we explored biological effects miR-217 on cancer. potently inhibited multiple metastatic traits, including cell migration, invasion, proliferation, apoptosis, EMT, as well angiogensis. These were achieved through downregulation target gene, AEG-1...
Abstract Functional, noncoding RNA of about 200 nucleotides in length are known as long (lncRNA). Advances ‐omics have revolutionized the information with respect to coding and regions genome. Several studies illustrated role lncRNA cell growth cancer. Profiling bioinformatic laryngeal cancer has identified LINC‐PINT one lncRNA. However, functional aspects deregulation not been studied tumors. In this study, expression normal tumor tissues were studied. Using a approach, microRNA (miRNA)...
Objective: Accumulating evidence suggests that microRNAs derived from macrophage exosomes can regulate the stemness and progression of cancer. However, interaction mechanisms between HCC cells tumor-associated macrophages remain unclear. Methods: Exosomes were extracted control or CD63 overexpression co-cultured with cells. The stemness, proliferation, epithelial-mesenchymal transition, in vivo tumorigenicity assessed to determine role CD63-high macrophage-derived exosomal miR-6876-5p HCC....
Human papillomavirus (HPV) is an etiological risk factor for oropharyngeal squamous cell carcinomas (OPSCC). Our study investigates the prevalence, prognostic, and clinicopathologic features of HPV-related cancer in Northeast China elucidates involvement p16 tumorigenesis progression OPSCC. Specimens from 1470 OPSCC patients collected 2000 to 2016 were analyzed using status HPV by polymerase chain reaction (PCR) immunohistochemistry. Overexpression was observed 81 (5.51%) cases, positive...
The aim of the present study was to examine potential role human heparin‑binding epidermal growth factor (HB‑EGF) secreted by M2 macrophages in development radioresistance head and neck squamous cell carcinoma (HNSCC). Immunohistochemistry used detect radiosensitivity papilloma virus (HPV)‑positive HPV‑negative HNSCC tissues immunohistochemical staining with specific antibodies for macrophage surface markers assess infiltration M1 HPV‑positive ‑negative tissues. expression HB‑EGF determined...
Abstract Head and neck squamous cell carcinoma (HNSCC) is a common cancer with high mortality. Anilin actin-binding protein (ANLN) has been reported to be associated carcinogenesis in multiple tumors. However, the expression pattern functional effects of ANLN HNSCC remain unclear. Clinical data online databases were used analyze its relationship patient survival. Expression two major splice variants was assessed tissues lines. The related mechanisms isoforms investigated vitro vivo. Our...
It has been recognized that depth of invasion (DOI) is closely associated with patient survival for most types cancer. The purpose this study was to determine the DOI optimal cutoff value and its prognostic in laryngeal squamous carcinoma (LSCC). Most importantly, we evaluated performance five candidate modified T-classification models patients LSCC. LSCC from Harbin Medical University Cancer Hospital Chinese Academy Sciences were divided into training group (n = 412) validation 147)....
Long noncoding RNAs (lncRNAs) have multiple functions with regard to the cancer immunity response and tumor microenvironment. The prognosis of head neck squamous cell carcinoma (HNSCC) is still poor currently, it may be effective predict clinical outcome immunotherapeutic HNSCC by immunogenic analysis. Therefore, using univariate COX analysis Lasso Cox regression, we identified a signature consisting 21 immune-related lncRNA pairs (IRLPs) that predicted Immunotherapeutic in HNSCC....
Accumulating evidence indicates an unexpected role of aberrant splicing in hepatocellular carcinoma (HCC) that has been seriously neglected previous studies. There is a need for detailed analysis alternative (AS) and its underlying biological clinical relevance HCC. In this study, information corresponding RNA sequencing data HCC patients were obtained from The Cancer Genome Atlas. Percent spliced (PSI) values transcriptional patterns genes determined the original using SpliceSeq. Then,...
Aims: To investigate the prognostic relevance of platelet volume indices for survival in laryngeal cancer. Patients & methods: The study included 640 patients with We analyzed optimal cutoff values through receiver operating characteristic analysis, then univariate factor and multivariate variables. Kaplan-Meier curves log-rank tests were conducted to compare overall (OS) recurrence-free rates between groups. Results: In elevated distribution width (PDW) PDW/platelet count ratio...