A5067042870- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Thyroid Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Thyroid Disorders and Treatments
- RNA modifications and cancer
- Extracellular vesicles in disease
- RNA Research and Splicing
- Microtubule and mitosis dynamics
- Cell Adhesion Molecules Research
- Skin and Cellular Biology Research
- Head and Neck Anomalies
- Circular RNAs in diseases
- Wnt/β-catenin signaling in development and cancer
- Cellular Mechanics and Interactions
- Mycobacterium research and diagnosis
- Ferroptosis and cancer prognosis
- Bioinformatics and Genomic Networks
Harbin Medical University
2019-2023
Third Affiliated Hospital of Harbin Medical University
2019-2023
Abstract Head and neck squamous cell carcinoma (HNSCC) is a common cancer with high mortality. Anilin actin-binding protein (ANLN) has been reported to be associated carcinogenesis in multiple tumors. However, the expression pattern functional effects of ANLN HNSCC remain unclear. Clinical data online databases were used analyze its relationship patient survival. Expression two major splice variants was assessed tissues lines. The related mechanisms isoforms investigated vitro vivo. Our...
It has been recognized that depth of invasion (DOI) is closely associated with patient survival for most types cancer. The purpose this study was to determine the DOI optimal cutoff value and its prognostic in laryngeal squamous carcinoma (LSCC). Most importantly, we evaluated performance five candidate modified T-classification models patients LSCC. LSCC from Harbin Medical University Cancer Hospital Chinese Academy Sciences were divided into training group (n = 412) validation 147)....
Long noncoding RNAs (lncRNAs) have multiple functions with regard to the cancer immunity response and tumor microenvironment. The prognosis of head neck squamous cell carcinoma (HNSCC) is still poor currently, it may be effective predict clinical outcome immunotherapeutic HNSCC by immunogenic analysis. Therefore, using univariate COX analysis Lasso Cox regression, we identified a signature consisting 21 immune-related lncRNA pairs (IRLPs) that predicted Immunotherapeutic in HNSCC....
The morbidity of thyroid carcinoma has been rising worldwide and increasing faster than any other cancer type. most common subtype with the best prognosis is papillary (PTC); however, exact molecular pathogenesis PTC still not completely understood.In current study, 3 gene expression datasets (GSE3678, GSE3467, GSE33630) 2 miRNA (GSE113629 GSE73182) were selected from Gene Expression Omnibus (GEO) database further used to identify differentially expressed genes (DEGs) deregulated miRNAs...
Aims: To investigate the prognostic relevance of platelet volume indices for survival in laryngeal cancer. Patients & methods: The study included 640 patients with We analyzed optimal cutoff values through receiver operating characteristic analysis, then univariate factor and multivariate variables. Kaplan-Meier curves log-rank tests were conducted to compare overall (OS) recurrence-free rates between groups. Results: In elevated distribution width (PDW) PDW/platelet count ratio...
<b><i>Purpose:</i></b> The aim of this study was to retrospectively identify the effect iodine on papillary thyroid cancer (PTC) process and investigate risk clinicopathologic characteristics cervical lymph node metastasis (CLNM) for achieving a better preventive strategy PTC. <b><i>Methods:</i></b> Totally 187 patients with CLNM 279 without (NCLNM) were enrolled, their urinary concentration (UIC) serum (SIC) measured. Logistic regressions used...
The aim is to estimate the prognostic value of lactate dehydrogenase (LDH) in patients undergoing surgical resection for laryngeal squamous cell carcinoma (LSCC). A total 640 resected LSCC were included. Preoperative was assessed. Kaplan-Meier survival analysis and Cox regression conducted overall (OS) recurrence-free (RFS). analysis, univariate multivariate demonstrated significant preoperative LDH. Although LDH predictor OS, it failed be a RFS. HR 95% CI 0.484 0.357-0.658 (P < 0.0001)....
Abstract Background Cuproptosis is a novel type of programmed cell death which plays an important role in the development and progression cancer. However, there limited amount research on cuproptosis-associated long non-coding RNAs (lncRNAs) head neck squamous carcinomas (HNSCCs). This study aimed to investigate predictive value cuproptosis-related lncRNA signature for HNSCC prognosis. Method Transcriptomic clinical data patients were obtained from Cancer Genome Atlas (TCGA). We established...
Abstract Objective Head and neck squamous cell carcinoma (HNSCC) is a common cancer with high mortality. Anillin (ANLN) has been identified as an actin-binding protein highly expressed in multiple cancers. However, the expression pattern functional effects of ANLN HNSCC remains to be unclear. Methods alternative splicing was assessed tissues lines. We investigated related mechanisms vitro vivo . Results Our results showed that two RNA ANLN-201 ANLN-210 were Knockout led inhibited...
Abstract Background : Laryngeal squamous cell carcinoma (LSCC) is a heterogeneous disease. In clinical practice, patients with similar clinicopathological characteristics often show different outcomes. This study evaluated the levels of primary LSCC intratumoral infiltrating lymphocytes (iTILs), tumor-infiltrating lymphocyte volume (TILV), frontier (fTILs), and their relations to patient's outcome. Materials methods: According 2017 International TILs Working Group, hematoxyline eosin-stained...
Abstract Background: It has been recognized that depth of invasion (DOI) is closely associated with patient survival for all types cancer. The purpose this study was to determine the optimal threshold and prognostic value in laryngeal squamous carcinoma (LSCC). Most importantly, we evaluated performance five candidate modified T-classification models patients LSCC. Methods: LSCC from Harbin Medical University Cancer Hospital Chinese Academy Sciences were divided into training group (n=412)...