A5013667153- Pain Mechanisms and Treatments
- Trigeminal Neuralgia and Treatments
- Neuropeptides and Animal Physiology
- Respiratory Support and Mechanisms
- Adenosine and Purinergic Signaling
- Airway Management and Intubation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Anesthesia and Sedative Agents
- Nerve injury and regeneration
- Anesthesia and Neurotoxicity Research
- Hepatitis Viruses Studies and Epidemiology
- Ultrasound in Clinical Applications
- Migraine and Headache Studies
- Cancer-related molecular mechanisms research
- Allergic Rhinitis and Sensitization
- Intraoperative Neuromonitoring and Anesthetic Effects
- Medicinal plant effects and applications
- Asthma and respiratory diseases
- Obesity and Health Practices
- Ferroptosis and cancer prognosis
- Hemodynamic Monitoring and Therapy
- Pediatric Pain Management Techniques
Nanchang University
2011-2024
Southern Medical University
2024
Nanfang Hospital
2024
Beijing Tian Tan Hospital
2018-2024
Capital Medical University
2009-2024
Chongqing Medical University
2016-2024
Luohe Medical College
2024
Beijing Tongren Hospital
2021-2022
The First Affiliated Hospital, Sun Yat-sen University
2021
Sun Yat-sen University
2021
Diabetic neuropathic pain (DNP) and depression (MDD) are common complications of diabetes mutually affect each other. As a member the ATP-gated ion channel family, P2X7 receptor is associated with transduction signal onset depression. The aim this study was to investigate effects dihydromyricetin (DHM) on rats comorbid DNP MDD. After model established, rat behavior changes were monitored by measuring mechanical withdrawal threshold, thermal latency, sugar water preference, immobility time in...
<abstract> <p>Trigeminal neuralgia is a debilitating condition characterized by severe facial pain. Carbamazepine has been widely used as first-line treatment option for trigeminal neuralgia, but there need to evaluate its safety and efficacy based on existing evidence. This meta-analysis aims systematically assess the available literature provide comprehensive evaluation of carbamazepine in neuralgia. A thorough search electronic databases yielded total 15 relevant studies that...
Abstract Background To date no study has evaluated the efficacy of preseasonal omalizumab therapy with cost effective dose and at appropriate time point compared standard medication in seasonal allergic rhinitis (SAR) patients. Methods This was a prospective randomized controlled open‐label single‐centre trial. 32 SAR patients were to receive single injection 300‐mg approximately two weeks before start pollen period (PP) or therapy. All completed daily questionnaires; recording symptoms, use...
Abstract Diabetic neuropathic pain (DNP) and depression (DP) are the common complications in patients with diabetes. The purpose of our research was to observe whether brain-derived neurotrophic factor (BDNF) levels tropomyosin receptor kinase B (TrkB) nervous system have effects on rats comorbid DNP DP, determine dihydromyricetin (DHM) may influence BDNF/ TrkB pathway mitigatethe comorbidity. study showed that DHM treatment could attenuates depressive behavior DP combined rats. Compared...
Trigeminal Neuralgia (TN) refers to recurrent severe paroxysmal pain in the distribution area of trigeminal nerve, which seriously affects quality life patients. This research applied chronic constriction injury infraorbital nerve (CCI—ION) approach induce an animal model TN rats. The mechanical threshold each group rats was determined postoperatively; expression P2X7 receptor ganglion (TG) assessed by qRT-PCR, immunofluorescence and Western blot; changes proinflammatory cytokines IL-1β...
Abstract Trigeminal neuralgia (TN), a sudden, needle-like pain in the distribution area of trigeminal nerve, can seriously affect physical and mental health patients. In chronic conditions including TN, increased levels brain-derived neurotrophic factor (BDNF) may enhance transmission. This study compares effect palmatine administration on expression BDNF its receptor TrkB (tropomyosin kinase B) ganglion cells Sprague-Dawley rats sham versus TN model group. Within 14 days surgery, mechanical...
Background/Aims: Diabetes mellitus (DM) has become an increasingly epidemic metabolic disease. Vascular endothelial cells play a key role in developing the cardiovascular complications of DM. The A2B receptor is expressed vascular cells, and may help regulate function cells. aim this study was to investigate protective effects oxymatrine (OMT) on human umbilical vein (HUVECs) from high glucose-induced cytotoxicity. Methods: Homology modeling molecular docking analysis were used detect...
Trigeminal neuralgia (TN) is a severe chronic neuropathic pain that mainly affects the distribution area of trigeminal nerve with limited treating efficacy. There are numerous treatments for TN, but currently main clinical approach to suppress by carbamazepine (CBZ). Brain-derived neurotrophic factor (BDNF) closely related pain. This study aims determine effects CBZ treatment on BDNF expression in both ganglion (TG) and serum TN via constriction injury infraorbital (ION-CCI) rat model.
: A common challenge of drug loading and delivery using magnetic resonance imaging (MRI) contrast agents (CAs) is the tendency aggregation precipitation at high conditions. Herein, we propose a generic strategy controlled ideal (CIA) to restrict tendency.
Ventilator-induced lung injury is a major cause of postoperative pulmonary complications (PPCs) in patients undergoing neurosurgery after general anesthesia. However, there no study on the effect lung-protective ventilation strategy neurosurgery. This single-center, randomized, parallel-group controlled trial which will be carried out at Beijing Tiantan Hospital, Capital Medical University. Three hundred and thirty-four intracranial tumor surgery randomly allocated to control group...
BACKGROUND: Intraoperative flash visual evoked potential (FVEP) can be used to monitor function during spine surgery. However, it is limited due the previous perception of its sensitivity inhalation anesthesia. We conducted this trial test noninferiority sevoflurane-propofol–balanced anesthesia (BA) versus popular propofol-based total intravenous (TIVA) on amplitude FVEP METHODS: A 60 patients undergoing surgery were randomized receive either (BA group) or (TIVA for maintenance. titrated...
Summary Neuropathic pain is a common and severely disabling state that affects millions of people worldwide. The P2X 3 receptor plays crucial role in facilitating transmission. Intermedin ( IMD ), which also known as adrenomedullin 2 AMD 2) newly discovered hormone member the calcitonin/calcitonin gene‐related peptide family. present research investigates effects on transmission neuropathic states mediated by receptors dorsal root ganglia DRG ). Chronic constriction injury CCI ) rats were...
Abstract Background Moderate-to-severe postoperative pain following craniotomy has a high incidence in pediatric patients. Such may cause agitation, intracranial hypertension, epileptic seizures, and hematoma, which affect morbidity mortality. Although scalp nerve block (SNB) achieves satisfactory relief except for suboccipital mid-craniotomy adults ropivacaine is widely used as long-acting peripheral agent children, there are few studies of SNB with patients undergoing craniotomy. In...