Scalp nerve blocks (SNB) may significantly reduce post-craniotomy pain (PCP) but only for a short period of time. Dexamethasone, as an adjuvant to local anesthetics, was reported prolong the analgesia duration never block; however, addition dexamethasone SNB is rare. We therefore tested hypothesis that bupivacaine in positive after craniotomy. Patients elective craniotomy were randomly assigned receive with alone compared and bupivacaine. The primary outcome analgesia. secondary outcomes...

OBJECTIVE Pulsed radiofrequency (PRF) combined with low-temperature continuous (CRF) might be a novel technique for relieving trigeminal neuralgia (TN). This study aimed to evaluate the efficacy and safety of high-voltage PRF CRF in primary TN. METHODS randomized controlled trial was performed between December 2, 2020, October 26, 2022. Eligible patients TN were randomly assigned at 1:1 ratio receive either voltage 70 V 42°C 600 seconds followed by 60°C 270 (PRF+CRF group) or (PRF group)....

BACKGROUND: Knee osteoarthritis (OA) is a common form of arthritis in elders which can lead to reduced daily activity and quality life. It important administer proper treatment with high efficacy low side effects. In this study, we evaluated the co-treatment oral duloxetine intraarticular (IA) injection hyaluronic acid (HA) corticosteroid (CS) patients knee OA. OBJECTIVES: This study aimed test hypothesis that an IA CS+HA combined could achieve pain management superior alone experiencing OA...

Incision-site infiltration with local anesthetics prevents pain on incision site, but relief is limited to the first few postoperative hours. Dexamethasone as an adjuvant successfully achieves better relief; however, this has not been studied in craniotomy patients yet.This a prospective, single-center, blinded, randomized, controlled trial included aged between 18 and 64 years, ASA physical status of I-II, scheduled for elective supratentorial tumor under general anesthesia. We screened...

Duloxetine has been reported to significantly relieve the pain of persistent idiopathic dentoalveolar (PIDP); however, number studies available is scarce and no study identified predictors response duloxetine for treatment PIDP.To report efficacy, safety, identification positive PIDP patients through a retrospective multicenter observational study.We retrospectively reviewed clinical database who were prescribed at 3 hospitals between January 2018 November 2021. Demographic pain-related...

Acute trigeminal neuralgia exacerbation is a common reason for frequent emergency department visits, that often occurs while waiting surgery, but evidence on effective drugs acute scant. Whether lidocaine aerosol could be rescue option the treatment of exacerbations worth exploring. Positive predictors analgesic effects also warrant further investigation.This retrospective study with total 152 patients. We analyzed efficacy exacerbations. A positive response was considered decrease in VAS...

Abstract Background Postherpetic neuralgia (PHN) is the most common chronic complication of herpes zoster (HZ) and results in severe refractory neuropathic pain. This study aimed at evaluating efficacy premedication with duloxetine prevention PHN. Methods The PROCESS trial a multicenter, randomized, open-label, blinded-endpoint used 1:1 duloxetine:control ratio. Adults 50 years or older HZ who presented vesicles within 72 hours were recruited. primary outcome was incidence PHN 12 weeks....

Whether 5% lidocaine-medicated plaster (LMP) is a valuable therapeutic option for the treatment of trigeminal neuralgia (TN) worth exploring. If LMP proven effective TN, positive predictors analgesic effects warrant further investigation.To evaluate efficacy and safety to explore predictive factors LMP.This retrospective observational study. We analyzed TN between March 2019 January 2022. The follow-up time was approximately 2 weeks, 1 month, months, 3 months after treatment. response...

Background: Postoperative pain after laminoplasty and laminectomy occurs partially from local trauma of the paraspinal tissue. Finding a multimodal analgesic cocktail to enhance duration effect infiltration analgesia is crucial. Because rapid onset long action betamethasone, we hypothesized that, preemptive regimen betamethasone ropivacaine reduces scores opioid demand, improves patient satisfaction following laminectomy. Materials methods: This prospective, randomized, open-label, blinded...

Abstract Background Dexamethasone added to incision‐site infiltration has been routinely used reduce pain after tonsillectomy in children. However, this not studied pediatric craniotomy patients yet. We hypothesized that with a combination of ropivacaine and dexamethasone might provide superior analgesia alone patients. Methods In multicenter, double‐blind, randomized, controlled trial, children aged 2–12 years, scheduled for craniotomy, were prospectively enrolled at two study centers, from...

Age-related hearing loss (ARHL) is much more prevalent with age, affecting not only peripheral but central auditory system. We have previously established an aging model of system in vitro using cultured cochlear basilar membrane. However, there no ideal accelerated on vitro. To establish the model, cortical neurons (ACNs) were primary and treated either vehicle or different doses D-galactose (D-gal). studied effect D-gal ACNs by evaluating hallmarks aging, including cell proliferation,...

Background: Approximately 55-87% of the patients undergoing craniotomy experience moderate to severe pain during first 48 hrs after surgery, which negatively influences patients' postoperative rehabilitation. Recently, local infiltration analgesia (LIA) has been widely performed clinically as a promising analgesic method that could avoid side effects analgesics but only short pain-free duration; researchers have clarified addition dexamethasone LIA provide significant and significantly...

Abstract Objective To further evaluate the efficacy and safety of computerized tomography–guided sphenopalatine ganglion–targeted pulsed radiofrequency treatment for patients with refractory episodic chronic cluster headache (CH). Methods Forty‐five CH 14 who underwent between January 2011 December 2018 at Beijing Tiantan Hospital were included analyzed in this retrospective cohort study. Results A total 59 106 procedures throughout observational period. Effective remission was observed...

Trigeminal neuralgia (TN) is characterised by a sudden, severe, electric shock like paroxysmal pain, which almost always associated with triggers. Carbamazepine the first-line medical management of TN. However, side effects are common. Currently, there no ideal treatment for Since known abnormality Na

Pain after craniotomy remains a poorly controlled problem that is mainly caused by the inflammatory reaction at incision site. Nowadays, systemic opioids use, as first-line analgesics, often limited because of adverse effects. Flurbiprofen axetil (FA) non-steroidal anti-inflammatory drug merged into emulsified lipid microspheres, which represent strong affinity to lesions. Local administration flurbiprofen surgical wound has induced enhanced analgesic efficacy and few or local effects oral...

Abstract Background Trigeminal neuralgia (TN) is a debilitating pain disorder that still lacks an ideal treatment option. Pulsed radiofrequency (PRF), especially with high output voltage, novel and minimally invasive technique. PRF regarded promising option for TN patients who respond poorly to medical treatment; however, the available evidence quality randomized controlled trials (RCTs). Our study aimed evaluate long-term (1 year 2 years) effects safety of high-voltage in primary provide...

Pain is common in the first 2 days after major craniotomy. Inadequate analgesia may lead to an increased risk of postoperative complications. Most pain following craniotomy arises from pericranial muscles and soft tissues scalp. Scalp nerve blocks with local anesthesia seem provide effective, safe, however, transient which does not meet requirements Currently, peripheral dexamethasone has been observed significantly prolong duration (e.g., saphenous block, adductor canal thoracic...

Objectives: This retrospective study aimed to investigate the effectiveness and safety of early combined therapy with CT-guided paravertebral nerve (PVN) pulsed radiofrequency (PRF) subcutaneous block on acute/subacute herpes zoster (HZ). Methods: A total 98 medical records were analyzed. All patients underwent PRF PVN immediately followed by a single lidocaine dexamethasone in phase. The efficacy was evaluated pain numeric rating scale (NRS) effective rate, which defined as percent cases...

In 1972, Stanley introduced supersolvable lattices, whose characteristic polynomials can be factored into a product of linear factors. Besides, he showed that graphical arrangement is if and only the graph chordal. Terao later discovered one define class hyperplanes with ''nice partition'', Orlik-Solomon algebra exhibits desirable tensor decomposition, leading to factorization its Poincar\'e polynomial terms. Supersolvable arrangements indeed have such nice partitions. Inspired by these...

Introduction Pre-emptive scalp infiltration with local anaesthetics is the simplest and most effective method to prevent postoperative incisional pain. However, of an anaesthetic only provides relatively short-term pain relief. Methylprednisolone (MP) treatment, administered as adjuvant at wound site, has been shown provide satisfactory management after lumbar laminectomy. there no evidence regarding efficacy MP for relief craniotomy. Currently, craniotomy in children undertreated....

Abstract Background Postherpetic neuralgia (PHN) is the most common complication attributed to herpes zoster, which involves reactivation of residual varicella zoster virus. It has been reported previously that pre-emptive amitriptyline following acute shown latent positive effects in prevention PHN. In this study, by interfering with same targets, norepinephrine and serotonin, we aim evaluate whether duloxetine may proactively prevent PHN development. Methods This a nationwide multicentric,...