A5101483168- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Tendon Structure and Treatment
- Wound Healing and Treatments
- Traumatic Brain Injury Research
- Bladder and Urothelial Cancer Treatments
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Berberine and alkaloids research
- Inflammation biomarkers and pathways
- Immune Response and Inflammation
- Apelin-related biomedical research
- Signaling Pathways in Disease
- Medicinal Plants and Bioactive Compounds
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Medical Imaging and Analysis
- Ion Transport and Channel Regulation
- MicroRNA in disease regulation
- Cervical and Thoracic Myelopathy
- Burn Injury Management and Outcomes
- Nutritional Studies and Diet
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Traumatic Ocular and Foreign Body Injuries
- Flavonoids in Medical Research
Army Medical University
2010-2024
Daping Hospital
2010-2024
Zhejiang Chinese Medical University
2013-2021
Harbin Medical University
2019
Fourth Affiliated Hospital of Harbin Medical University
2019
Dalian Medical University
2014-2019
Chongqing Medical University
2014-2019
Second Affiliated Hospital of Chongqing Medical University
2014-2019
Capital Medical University
2017
Beijing Tian Tan Hospital
2017
No definitive conclusion can be made on the best choice of anesthesia for people with acute posterior circulation stroke during endovascular treatment. Only a few observational studies have focused this topic in recent years, and they differing conclusions. To examine whether conscious sedation (CS) is feasible alternative to general (GA) treatment patients stroke. A randomized parallel-group exploratory trial blinded end point evaluation (Choice Anesthesia Endovascular Treatment Acute...
Abstract Acute respiratory distress syndrome (ARDS) is characterized by increased pulmonary inflammation and endothelial barrier permeability. Omentin has been shown to benefit obesity-related systemic vascular diseases; however, its effects on ARDS are unknown. In the present study, level of circulating omentin in patients with was assessed appraise clinical significance ARDS. Mice were subjected administration adenoviral vector expressing (Ad-omentin) one-shot treatment recombinant human...
Abstract Recent studies have shown that after traumatic brain injury (TBI), the number of autophagosomes is markedly increased in cells surrounding wound; however, whether autophagy enhanced or suppressed by TBI remains controversial. In our study, we used a controlled cortical impact system to establish models mild, moderate and severe TBI. mild model, levels autophagy-related protein 6 (Beclin1) 12 (ATG12)-autophagy-related 5 (ATG5) conjugates were increased, indicating initiation...
Our previous works have demonstrated that Chinese herb medicine yanhusuo (Corydalis W. T. Wang) has strong anti-cancer proliferation effect in MDA-MB-231 cells. The goal of this study was to find out the synergic cytotoxicity three natural compounds, tetrahydropalmatine (THP), berberine (Ber), and dehydrocorydaline (DHC), isolated from C. Wang.The IC50 THP Ber DHC single use, as well combination use at fixed ratios doses measured by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium...
We recently demonstrated that Ski is a novel wound healing-related factor promotes fibroblast proliferation and inhibits collagen secretion. Here, we show increasing local expression by gene transfer not only significantly accelerated healing relieving inflammation, accelerating re-epithelialization formation of granulation tissue, but also reduced scar decreasing production in rat dermal wounds. Similarly, ski healing, the protuberant height volume scars increased maturity hypertrophic...
Metastasis remains the most deadly aspect of cancer and still evades direct treatment. Thus, there is a great need to develop new treatment regimens suppress tumor cells that have escaped surgical removal or may already disseminated. We found tetrandrine (TET) exhibits anticolon activity. Here, we investigate inhibition effect TET breast metastasis, angiogenesis its molecular basis underlying TET's anticancer compare with chemotherapy drug doxorubicin in 4T1 bearing BALB/c mice model find an...
Pulmonary edema is one of the pathological characteristics acute respiratory distress syndrome (ARDS). The epithelial sodium channel (ENaC) thought to be rate-limiting factor for alveolar fluid clearance (AFC) during pulmonary edema. peroxisome proliferator-activated receptor γ (PPARγ) agonist rosiglitazone was shown stimulate ENaC-mediated salt absorption in kidney. However, its role lung remains unclear. Here, we investigated PPARγ find out whether it can regulate AFC injury (ALI). We also...
Traumatic brain injury-induced acute lung injury (TBI-ALI) is a serious complication after for which predictive factors are lacking. In this study, we found significantly elevated blood glutamate concentrations in patients with TBI or multiple peripheral trauma (MPT), and more severe injuries showed higher longer durations of levels. Although the increase amplitude was similar between two groups, duration TBI. There were no significant differences MPT regard to ALI status, but levels TBI-ALI...
To investigate the effects of three different ways chronic caffeine administration on blast-induced memory dysfunction and to explore underlying mechanisms. Adult male C57BL/6 mice were used randomly divided into five groups: control: without blast exposure, con-water: administrated with water continuously before after traumatic brain injury (bTBI), con-caffeine: for 1 month bTBI, pre-caffeine: chronically bTBI withdrawal post-caffeine: bTBI. After being subjected moderate intensity injury,...
<b><i>Background:</i></b> The epithelial sodium channel (ENaC) is the driving force for pulmonary edema absorption in acute lung injury (ALI). Netrin-1 a newly found anti-inflammatory factor that works by activating adenosine 2B receptor (A2BAR). Meanwhile, activated A2BAR has potential to enhance ENaC-dependent alveolar fluid clearance (AFC). However, whether netrin-1 can increase ENaC-mediated AFC remains unclear. <b><i>Objectives:</i></b> To...
Spatial recognition memory impairment is an important complication after traumatic brain injury (TBI). We previously found that spatial can be alleviated in adenosine A2A receptor knockout (A2A R KO) mice TBI, but the mechanism remains unclear. In current study, we used manganese-enhanced magnetic resonance imaging and Y-maze test to determine whether electrical activity of neurons retrosplenial cortex (RSC) was reduced impaired wild-type (WT) moderate TBI. Furthermore, damaged by...
We previously demonstrated that cellular Sloan-Kettering Institute (c-Ski) played a dual role, both promoting wound healing and alleviating scar formation. However, its mechanism therapeutic effects are not clear, especially compared with widely used treatments, such as basic fibroblast growth factor (bFGF) administration. Ski treatment led to an even shorter time more significant reduction in area than bFGF treatment. The underlying this difference was related reduced inflammatory response,...
Adenosine receptor-mediated signaling, especially adenosine A
Objective: To study the immune regulation function of high expressing interleukin-10 (IL-10) in B cells on CD4(+)T-cells periodontitis mouse model. Methods: Twenty-four 7-weeks-old female C57BL/6 mice were randomly and equally assigned into 4 groups: healthy control group (HC group, n=6), ligation combined Porphyromonasgingivalis (Pg) infection (P Pg with non-stimulated cell transfer (P+NSB n=6) stimulated (P+SB n=6). Ligation maxillary second molar was used to induce mice. The exogenous or...
Objective: To explore the expression of EGFR and PCNA in lung squamous cell carcinomas adenocarcinomas, relationships between their overexpression cancer tissue typing or lymphatic metastasis. Method: Detect 44 cases similarly differentiated 16 normal by immunohistochemistry. Result: The was significantly higher than that tissue. Meanwhile, no significant difference existed adenocarcinomas (P>0.05), nor lymph node metastatic negative (P>0.05). Conclusion: were involved onset...