A5028777567- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- interferon and immune responses
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- RNA modifications and cancer
- Mechanisms of cancer metastasis
- Invertebrate Immune Response Mechanisms
- Magnesium Alloys: Properties and Applications
- Medicinal Plant Pharmacodynamics Research
- Cancer-related gene regulation
- Multiple Myeloma Research and Treatments
- Respiratory Support and Mechanisms
- Dermatology and Skin Diseases
- Liver Disease and Transplantation
- Chronic Kidney Disease and Diabetes
- Neurological Disease Mechanisms and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Viral Infections and Vectors
- Ecology and Conservation Studies
- Psoriasis: Treatment and Pathogenesis
- Horticultural and Viticultural Research
- Plant Gene Expression Analysis
Hebei University of Chinese Medicine
2024
Shanxi Academy of Forestry
2021-2023
Tianjin University of Traditional Chinese Medicine
2021-2023
Rongcheng City People's Hospital
2023
Hebei Medical University
2003-2022
Daping Hospital
2020-2022
Army Medical University
2008-2022
Nanjing University of Chinese Medicine
2019-2020
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017-2018
Chongqing Medical University
2017-2018
Several confirmed genetic susceptibility loci involved in the interferon signaling and Th17/B cell response for SLE Chinese Han populations have been described. Available data also indicate that sex-specific differences contribute to susceptibility. The aim of this study was test gene–gene/gene-sex epistasis (interactions) these known lupus loci. Six single-nucleotide polymorphisms (SNPs) MiR146a, IRF5, IKZF1, ETS1 IL21 were genotyped by Sequenom MassArray system. A total 1,825 subjects (858...
Previous studies have shown that individuals with low muscle mass exhibit an increased risk of nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the association between NAFLD and sarcopenia in elderly patients.We classified participants into sarcopenia/nonsarcopenia groups based on dual-energy X-ray absorptiometry (DXA), strength (grip strength), or/and physical performance (6 m usual gait speed). We diagnosed by ultrasonography combined history alcohol intake....
Abstract MicroRNAs (miRNAs) are important effectors in mediating host–pathogen interaction. In this report, coelomocytes miRNA libraries of three Japanese sea cucumbers Apostichopus japonicus were built by Illumina ® Hiseq2000 from different time points after lipopolysaccharide challenge (at 0 h, 6 h and 12 h). The clean data received high throughput sequencing used to sequences analysis. Referenced the Strongylocentrotus purpuratus genome, 38 conserved miRNAs found candidates predicted...
Quercus liaotungensis Koidz. is an ecologically and economically important tree species widely distributed in Northern China. However, the effective assessment, utilization, protection of Q. resources remain unexplored.In total, 120 samples obtained from 12 populations China were investigated for genetic diversity structure using 19 simple sequence repeat (SSR) primer pairs.The total number alleles detected was 293, average allele (Ne) 6.084, differentiation coefficient (Fst) 0.033, mean...
Cinobufacini injection (CI), an aqueous extract of Cutis Bufonis, is clinically used for cancer therapy in China, but its molecular mechanism the treatment osteosarcoma (OS) remains unclear. We constructed U2OS ectopic subcutaneous tumor model to verify anti-OS effect CI vivo. Meanwhile, cell proliferation and MG63 cells was monitored vitro using CCK-8 assay, colony formation morphological changes. Cell cycle arrest apoptosis were detected by flow cytometry western blot, which showed that...
Background: TGF-β1 promotes cell proliferation in only some tumors and exerts bidirectional regulatory effects on the of fibroblasts. This study intends to explore whether mechanism is related increased expression Ski. Methods: Cell fibrosarcoma line L929 was assessed with an ELISA BrdU kit. The mRNA protein levels corresponding factors were measured by RT-qPCR, immunohistochemistry or Western blotting vitro vivo. Additionally, c-Ski knocked down using RNAi. Ski human dermatofibrosarcoma...
Abstract The performance index of overall photochemistry (PI total ) is widely used in photosynthesis research, but the PI interspecies differences are unclear. To this end, seeds Quercus liaotungensis from 10 geographical provenances were planted two different climate types. Two years later, leaf relative chlorophyll content (SPAD) and a fluorescence transient seedlings measured. Meanwhile, environmental factors provenance location, including temperature, precipitation, solar radiation,...
Long interspersed nuclear element‑1 (L1) is highly expressed in the early embryos of humans, rodents and fish. To investigate molecular mechanisms underlying high expression L1 during embryonic development, a C1‑open reading frame (ORF)2 vector was constructed which ORF2 human (L1‑ORF2) inserted into pEGFP‑C1 plasmid. C1‑ORF2 injected zebrafish (EZEs) to observe EGFP reporter protein by fluorescence microscopy. RNA‑seq RT‑qPCR were used detect effects lipovitellin (LV) on gene EZEs. The...
Chronic obstructive pulmonary disease (COPD) is a that affects the entire body. Sarcopenia, one of adverse manifestations whole body, can lead to variety outcomes. The worldwide studies have shown sarcopenia was associated with COPD. This article aims further enrich this research direction by focusing on relationship between and COPD in Chinese inpatients. subjects study were patients hospitalized Department Respiratory Critical Care Medicine Rongchang People's Hospital Chongqing...
This paper investigates the effects of irradiation technology on major components Panax Notoginseng (Sanqi) herbal medicine. Irradiation technology, particularly 60Co-γ irradiation, has been widely used as an effective sterilization method in food and pharmaceutical processing. In field traditional Chinese medicine (TCM), demonstrated unique advantages, effectively eliminating microbial contamination while preserving main therapeutic efficacy TCM. first introduces basic principles its...
To investigate resource allocation and adaptation strategies of Sorbus spp. under different environment soil conditions, four L. species (Sorbus hupehensis C. K. Schneid, pohuashanensis (Hance) Hedl, discolor (Maxim.) Maxim, koehneana Schneid) were selected as the study materials. Phenotypic traits including seed mass, fruit colour measured analyzed. Linear Mixed-Effects Models employed to analyze associations between phenotypic environment, Maxent model was used predict potential...