A5024880642- Long-Term Effects of COVID-19
- Tuberculosis Research and Epidemiology
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Nosocomial Infections in ICU
- Neonatal and Maternal Infections
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Pleural and Pulmonary Diseases
- Diagnosis and treatment of tuberculosis
- Urinary Tract Infections Management
- Congenital Heart Disease Studies
- Pediatric Urology and Nephrology Studies
- COVID-19 Impact on Reproduction
- Pulmonary Hypertension Research and Treatments
- Inflammasome and immune disorders
- Infectious Diseases and Tuberculosis
- Streptococcal Infections and Treatments
- Salivary Gland Disorders and Functions
- Aortic Disease and Treatment Approaches
- Diet and metabolism studies
- Exercise and Physiological Responses
- Respiratory viral infections research
Agostino Gemelli University Polyclinic
2021-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
Università Cattolica del Sacro Cuore
2022-2024
University of L'Aquila
2021-2024
San Salvatore Hospital
2023-2024
Torino e-district
2024
Guglielmo da Saliceto Hospital
2022-2023
Policlinico San Matteo Fondazione
2022
Policlinico di Modena
2017
I.R.C.C.S. Oasi Maria SS
1985
Paediatric Long Covid has been reported globally,1 however, no previous analysis the different risk of persistence symptoms in children infected with SARS-CoV-2 variants. This is a prospective follow-up first microbiologically (through Polymerase Chain Reaction nasopharyngeal swab) confirmed infection evaluated in-person at referral paediatric post-covid clinic Rome, Italy (Ethic approval ID4518, Prot0040139/21). Children were referred to our by inpatient ward, emergency department or family...
Background: Cardiopulmonary exercise testing (CPET) is a noninvasive and nonexpensive diagnostic tool, that provides comprehensive evaluation of the pulmonary, cardiovascular, skeletal muscle systems’ integrated reactions to exercise. CPET has been extensively used in adults with Long COVID (LC), while evidence about its role children this condition scarce. Methods: Prospective, case-controlled observational study. Children LC control group healthy underwent CPET. findings were compared...
Emerging data suggests that endotheliopathy changes can be associated with post covid condition (PCC) in adults. Research on the matter children is lacking. We analyzed an extended coagulation profile including biomarkers of endothelial damage PCC and compared it a control group fully recovered post- SARS-CoV-2 infection. A case-control study enrolling below 18 years age previous microbiologically confirmed infection pediatric post-covid unit Italy ≥ 8 weeks after initial Samples were taken...
Limited data on the coagulation profile in children affected by SARS-CoV-2 infection are available. We aimed to evaluate role of d-dimers as predictors poor outcomes a pediatric population or multisystem inflammatory syndrome (MIS-C). performed retrospective cross-sectional multicenter study. Data from four different centers were collected. Laboratory tests, when performed, collected at time diagnosis, and 24, 48, 72, 96, 120 beyond h diagnosis; blood counts with formula, an international...
Background-Central precocious puberty (CPP) is characterized by clinical, biochemical, and radiological features similar to those of normal puberty, but CPP occurs before the age eight in girls nine boys, subsequently leading a reduction final body height adulthood due premature fusion growth plates. The diagnosis confirmed with gonadotropin-releasing hormone (GnRH) stimulation test, which can lead different interpretations because diagnostic peak levels luteinizing (LH) vary. Patients...
Introduction: Fever is among the most common reason for medical assessment and antibiotic prescription in practice. The aim of this study was to evaluate positive negative predictive values rapid nasopharyngeal swabs respiratory pathogens discriminate viral from bacterial infections. Methods: We prospectively tested children with signs and/or symptoms infections (e.g., fever, cough, wheezing, suspected urinary tract infection) admitted a paediatric department. Following discharge, clinical...
Olfactory and gustative dysfunctions are two of the most common post-acute sequelae SARS-CoV-2 infection in children, which can have a negative impact on routines children families. As several had COVID-19 since Omicron variant, it is important to investigate if this increase infections reflected higher olfactory/taste disfunctions. The primary aim study was characterize presence olfactory/gustative problems cohort its evolution, association with risk factors such as hospitalization,...
Background and aim: Persisting gastrointestinal symptoms are reported to be relatively common in children with long COVID; however, their detailed characterization long-term outcomes have not yet been described. Methods: We performed a retrospective study aiming investigate the temporal evolution of SARS-CoV-2, from acute infection 18-months follow-up. To further possible therapeutic strategies, we evaluated role lactoferrin improving these children, compared those treated. Results: A total...
Lung ultrasound (LUS) can detect lower respiratory tract involvement in children with acute SARS-CoV-2 infection. However, its role follow-up assessments is still unclear. To describe LUS findings after infection, we conducted a prospective study population of pediatric patients referred to the post-COVID unit tertiary center during period from February 2021 May 2022. Children were classified as recovered infection or persisting symptoms. was performed all and score (ranging 0 36 points)...
Higher number of monocytes and neutrophils may correlate with active tuberculosis (TB) in children. However, the few paediatric studies available are limited by small numbers children TB disease or infection included.We calculated monocyte-to-lymphocyte-ratio (MLR), neutrophil-to-lymphocyte-ratio (NLR) neutrophil-to-monocyte-plus-lymphocyte-ratio (NMLR) TB, latent (LTBI), other infectious non-infectious conditions healthy evaluated two referral centres Rome.Overall, 649 were included (41.8%...
Background There is increasing evidence that the COVID-19 pandemic disrupted childhood immunization services. However, detailed reports on immunizations and preventive antimalarial prophylactic treatments delivered how trends changed in referral centers low-income countries are still missing. Methods We performed a retrospective cross-sectional study. Data for vaccinations administered to children <5 years of age, according local vaccination schedule, were extracted from official...
Introduction: There is marked heterogeneity in clinicians’ choice of antibiotic duration for pediatric urinary tract infections (UTIs). Most patients with bacterial UTIs still receive between 7 and 10 days antibiotics. Prolonged exposure drives the emergence resistance increases occurrence adverse effects. increasing evidence that shorter regimens may be equally effective compared longer ones. However, studies evaluating therapies children hospitalized have not yet been performed. Methods:...
The human bladder has been long thought to be sterile until that, only in the last decade, advances molecular biology have shown that urinary tract is populated with microorganisms. relationship between urobiota and development of disorders now great interest. Patients spina bifida (SB) can born (or develop over time) neurological deficits due damaged nerves originate lower part spinal cord, including neurogenic bladder. This condition represents a predisposing factor for infections so most...
The safety profile of baricitinib (BARI), a Janus kinase inhibitor broadly used for the treatment rheumatoid arthritis (RA), includes asymptomatic laboratory abnormalities, such as an increase in creatine (CK). Data from randomized controlled trials suggest that concomitant myalgia is rare RA and does not lead to drug discontinuation. We describe case 68-year-old Caucasian female with longstanding, multi-failure who started BARI achieved disease remission. However, she developed symptomatic...
(1) Background: Uric acid is a well-known cardiovascular (CV) risk factor in the general population but its role setting of rheumatic diseases other than gout unclear. (2) Methods: This retrospective study investigating cohort 105 pSS patients recording clinical, serological, and CV-related variables including adherence to Mediterranean diet. (3) Results: We observed strong relationship between disease activity, interstitial lung (ILD), CV events. The association ILD events was dependent on...
During the COVID-19 pandemic, use of salivary swabs (SS) to detect SARS-CoV-2 virus has been implemented and widely studied in adults children. However, role SS detecting other common respiratory viruses children is poorly investigated.Children younger than 18 years age admitted with signs symptoms underwent both nasopharyngeal procedures. Sensitivity, specificity, positive predictive value (PPV), negative (NPV) were calculated, considering swab result as gold standard.A total 83 patients...
The strong genetic association between HLA-B*27 and spondyloarthritis (SpA) accounts for about 90% of the susceptibility to axial SpA (axSpA), presence is helpful in classifying patients according Assessment SpondyloArthritis International Society (ASAS) classification criteria. However, over years, other HLA-B alleles have been associated with an increased risk developing SpA; on this basis, aim our study was describe demographic, clinical, radiological characteristics a cohort who were...