A5042018060- Influenza Virus Research Studies
- Respiratory viral infections research
- Animal Disease Management and Epidemiology
- interferon and immune responses
- Immune Response and Inflammation
- Neuroscience of respiration and sleep
National Institute of Allergy and Infectious Diseases
2021-2024
National Institutes of Health
2011-2024
Influenza A viruses (IAVs) present major public health threats from annual seasonal epidemics and pandemics adapted to a variety of animals including poultry, pigs, horses. Vaccines that broadly protect against all such IAVs, so-called “universal” influenza vaccines, do not currently exist but are urgently needed. Here, we demonstrated an inactivated, multivalent whole-virus vaccine, delivered intramuscularly or intranasally, was protective challenges with multiple IAV hemagglutinin...
Zoonotic influenza A virus (IAV) infections pose a substantial threat to global health. The RNA-dependent RNA polymerase (RdRp) comprises the PB2, PB1, and PA proteins. Of last four pandemic IAVs, three featured avian-origin PB1 genes. Prior research linked these avian genes increased viral fitness when reassorted with human IAV This study evaluated chimeric RdRps from 1918, 1957, 1968 IAVs in low pathogenic (LPAI) background assess activity pathogenicity. Substituting reduced activity,...
Abstract Influenza A viruses (IAVs) present major public health threats from annual seasonal epidemics, pandemics caused by novel virus subtypes, and adapted to a variety of animals including poultry, pigs horses. Vaccines that broadly protect against all such IAVs, so-called “universal” influenza vaccines, do not currently exist, but are urgently needed. This study demonstrates an inactivated, multivalent whole vaccine, delivered intramuscularly or intranasally, is protective challenges...