The aloe ingredients responsible for physiological effects and the concentrations required to exert their biological activities are not fully understood. This study compares anti-inflammatory of aloin aloe-emodin with other polyphenols. Our results demonstrated that dose-dependently inhibited inducible nitric oxide synthase (iNOS) mRNA expression (NO) production at 5–40 μm. In addition, levels cyclooxygenase-2 (COX-2) prostaglandin E2 (PGE2) were suppressed by 40 μm aloe-emodin. Aloin also...

This study was undertaken to evaluate the clinical efficacy, safety, and histological changes induced by dietary omega-3 fatty acid γ-linoleic in acne vulgaris. A 10-week, randomised, controlled parallel intervention performed 45 participants with mild moderate acne, which were allocated either an group (2,000 mg of eicosapentaenoic docosahexaenoic acid), a (borage oil containing 400 or control group. After 10 weeks supplementation, inflammatory non-inflammatory lesions decreased...

Because of unsatisfactory treatment options for prostate cancer (CaP) there is a need to develop novel preventive approaches this malignancy. One such strategy through chemoprevention by the use non-toxic dietary substances and botanical products. We have shown previously that panduratin A isolated from extract Kaempferia pandurata ( Zingiberaceae ) strong inhibitor cyclooxygenase-2 in RAW264.7 cells induces apoptosis HT-29 cells. In present study, we provide evidence androgen-independent...

Post-inflammatory erythema is a common result of acne inflammation and cosmetically unacceptable without effective treatment. Fractional microneedling radiofrequency (FMR) has potential for treatment post-inflammatory erythema. The aim this study was to evaluate the efficacy safety A retrospective chart review undertaken 25 patients treated with 2 sessions at 4-week intervals 27 oral antibiotics and/or topical agents. Efficacy assessed through an investigator's global assessment photographs,...

Abstract Reactive oxygen species (ROS), such as superoxide anions and hydroxyl radicals, are associated with carcinogenesis other pathophysiological conditions. Therefore, elimination or inactivation of ROS inhibition their excess generation may be beneficial in terms reducing the risk for cancer diseases. Ganoderma lucidum has been used traditional oriental medicine potential antiinflammatory antioxidant activities. In present study, we tested amino‐polysaccharide fraction (designated...

N-nitrosamines, widespread contaminants, can be formed from precursors in food including nitrites and amines. The effects of six cooking methods (roasting, stir frying/griddling, frying, blanching, boiling, others) were investigated terms the concentrations seven N-nitrosamines N-nitrosodimethylamine, N-nitrosomethylethylamine, N-nitrosodiethylamine, N-nitrosodibutylamine, N-nitrosopiperidine, N-nitrosopyrrolidine, N-nitrosomorpholine Total Diet Study samples. In conclusion,...

An active compound identified as panduratin A was isolated from a methanol extract of Kaempferia pandurata (Zingiberaceae). We examined the effect on nitric oxide (NO) and prostaglandin E2 (PGE2) production induced by lipopolysaccharide (LPS) in RAW264.7 cells. Modulations iNOS COX-2 enzyme expression were evaluated Western blotting. Panduratin strongly inhibited both NO (IC50 : 0.175 μM) PGE2 0.0195 suppressed without any appreciable cytotoxic cells dose-dependent manner. also...

In the present study, degradation of amygdalin in human digestive fluids and absorption its metabolites by small intestine were evaluated simulating a gastrointestinal digestion model combined with intestinal cell culture. Orally administered was degraded into prunasin enzymes after passing through salivary phases. Prunasin, major metabolite fluids, incubated caco-2 culture system. Prunasin mandelonitrile β-glucosidase then hydroxylated across wall, producing hydroxymandelonitrile (149 Da)....

Chronic otitis media (COM) is treated medically and/or surgically. Ossiculoplasty for COM with severe-to-profound hearing loss has not been recommended because the severity of before surgery negatively associated postoperative improvement. Our study assessed effectiveness ossiculoplasty and identified prognostic factors favorable outcomes. We retrospectively reviewed medical records 182 patients who underwent tympanoplasty mastoidectomy between January 2017 December 2018. Air conduction,...

Ethyl carbamate has been associated with cancer for several decades. It is mainly found in fermented foods and beverages. In view of the importance Korean diet significant level ethyl expected, we determined concentrations some staple food items estimated daily intake population. commercial samples kimchi, soy sauce, vinegar, soybean paste, alcoholic beverages were by gas chromatography-mass spectrometry/selective ion monitoring (GC-MS/SIM). Homemade sauce kimchi also analysed. The maximum...

4-Hydroxy-2-alkenals are cytotoxic aldehydes generated from the oxidation of n-3 and n-6 polyunsaturated fatty acids. The compounds have shown various biological effects via Schiff base adducts or Michael addition at levels higher than physiological ones. To assess human exposure to 4-hydroxy-2-alkenals in diet, vegetable oils, fish shellfish were monitored using GC/MS/SIM. 2001 National Health Nutrition Survey (2002) data employed for dietary intake pattern. Korean daily...

Aloe products are one of the top selling health-functional foods in Korea, however adequate level intake to achieve desirable effects not well understood. The objective this study was determine intestinal uptake and metabolism physiologically active aloe components using vitro absorption model. Caco-2 cell monolayer everted gut sac were incubated with 5-50 microM aloin, aloe-emodin, aloesin. basolateral appearance test compounds their glucuronosyl or sulfated forms quantified HPLC. % aloesin...

This study was conducted to investigate the influence of dietary rapeseed meal (RSM) on growth performance, blood profiles, nutrient digestibility and economic benefit growing-finishing pigs. A total 120 growing pigs ([Yorkshire×Landrace] ×Duroc) with an initial body weight (BW) 29.94±0.06 kg were used in this experiment. Pigs randomly allotted into 1 5 treatments a randomized complete block design 6 replicates 4 per pen. Treatments divided by RSM supplementation levels (0%, 3%, 6%, 9%, or...

The dietary intakes and sources of isoflavones coumestrol were estimated for each age group Koreans based on data from the Korean Nutrition Survey conducted in 1998. For quantitative levels coumestrol, our previous study monitoring phytoestrogens 220 leguminous foodstuffs was employed median value food adopted. total intake per capita as 23.3 mg/day, which constituted 14.2 mg daidzein, 6.7 genistein, 0.9 glycitein, 1.0 formononetin, 0.2 biochanin A, 0.3 coumestrol. top five foods arrowroot,...

Acrylamide, a known carcinogen, is formed during preparation of food containing reducing sugar and asparagine. Because acrylamide exposure the population primarily through food, maximum levels in were set by European Commission 2017. Moreover, 2016 Korean Total Diet study, showed lowest margin among 23 food-processing-related chemicals, necessitating risk reduction options. Therefore, objective this study was to determine variation content different items identify categories, provide options...

4-Hydroxy-2-hexenal (HHE) and 4-hydroxy-2-nonenal (HNE) were determined using selected ion-monitoring gas chromatography-mass spectrometry (GC-MS) in 56 kinds of commercially available PUFA-fortified foods including infant formulas baby foods. HHE HNE, each specifically coming from the oxidation n-3 n-6 polyunsaturated fatty acids (PUFA), observed at <10-77 41-132 microg kg(-1) (n = 12) <10-52 36-116 7), respectively. 4-Hydroxy-2-alkenals further 10 30 days after opening an attempt to...

Glucosinolate, sulfur-containing organic anions bonded to glucose, is found in plants including the family of Brassicaceae. Glucosinolate hydrolyzed by myrosinase and produces various by-products that possess biological activities. Among decomposed products, thiocyanate known for its adverse effects on thyroid metabolism due competition with iodine. This concern Korean dietary habits consist consumption large amounts Brassicaceae vegetables such as cabbage radishes, which may be correlated...

Four artificial sweeteners, i.e., sodium saccharin, aspartame, acesulfame-K and sucralose, are permitted for use in Korea, recent regulatory changes have expanded the number of food categories which they may be used. sweeteners were determined simultaneously more than 900 items from 30 that commercially available Korean markets, including both domestic imported products, using high-performance liquid chromatography evaporative light-scattering detection (ELSD). A new procedure 75% acetone to...