A5102866998- Immune Response and Inflammation
- Escherichia coli research studies
- Pneumothorax, Barotrauma, Emphysema
- Advanced biosensing and bioanalysis techniques
- Phytoestrogen effects and research
- RNA Interference and Gene Delivery
- Ear Surgery and Otitis Media
- Diet, Metabolism, and Disease
- Sperm and Testicular Function
- Reproductive System and Pregnancy
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Sinusitis and nasal conditions
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Streptococcal Infections and Treatments
- interferon and immune responses
- Endometriosis Research and Treatment
- GABA and Rice Research
- Metabolomics and Mass Spectrometry Studies
- Virus-based gene therapy research
- Bacterial Genetics and Biotechnology
- Reproductive Biology and Fertility
- Dermatological and COVID-19 studies
- Nasal Surgery and Airway Studies
- Cytokine Signaling Pathways and Interactions
Kyungpook National University
2023-2025
Pohang University of Science and Technology
2013-2014
Korea Basic Science Institute
2008-2010
Significance Toll-like receptors (TLRs) are key innate immune that sense pathogen- or danger-associated molecules. The members of the TLR family can be classified into two groups based on their subcellular localization patterns—cell surface vs. endolysosomes—but how individual is targeted to its destination largely unknown. UNC93B1 was regarded specifically bind endolysosomal TLRs in endoplasmic reticulum and deliver them endolysosomes with no role for surface-localized TLRs. In this study,...
TLRs are divided into two groups based on their subcellular localization patterns. TLR1, 2, 4, 5, and 6 expressed the cell surface, whereas nucleotide-sensing TLRs, such as TLR3, 7, 8, 9 stay mainly inside cells. The polytopic membrane protein UNC93B1 physically interacts with delivers them from endoplasmic reticulum to endolysosomes, where recognize ligands initiate signaling. In cells nonfunctional UNC93B1, nucleic acid-sensing fail exit consequently do not signal. However, detailed...
Chronic otitis media (COM) is treated medically and/or surgically. Ossiculoplasty for COM with severe-to-profound hearing loss has not been recommended because the severity of before surgery negatively associated postoperative improvement. Our study assessed effectiveness ossiculoplasty and identified prognostic factors favorable outcomes. We retrospectively reviewed medical records 182 patients who underwent tympanoplasty mastoidectomy between January 2017 December 2018. Air conduction,...
COVID-19 requires quarantine for 7 days from the diagnosis, and 10−20 critically ill patients. Therefore, in patients with both necrotizing fasciitis COVID-19, prognosis may be poor as treatment could delayed. We would like to report our experience treating a patient discuss what should prepared future. A 60-year-old man was quarantined after being diagnosed but visited hospital due worsening sore throat left facial swelling. He septic condition severe gangrenous changes deep neck space were...