A5101701578- Tea Polyphenols and Effects
- Phytochemicals and Antioxidant Activities
- CAR-T cell therapy research
- Skin Protection and Aging
- Food Quality and Safety Studies
- Allergic Rhinitis and Sensitization
- Immunotherapy and Immune Responses
- Phytoestrogen effects and research
- Dermatology and Skin Diseases
- Fuel Cells and Related Materials
- Polysaccharides and Plant Cell Walls
- Pharmacological Effects of Natural Compounds
- Air Quality and Health Impacts
- melanin and skin pigmentation
- Food composition and properties
- Virus-based gene therapy research
- Advancements in Solid Oxide Fuel Cells
- Ginseng Biological Effects and Applications
- Advanced Glycation End Products research
- Seed and Plant Biochemistry
- Multicomponent Synthesis of Heterocycles
- Immunotoxicology and immune responses
- Fullerene Chemistry and Applications
- Hydrogen's biological and therapeutic effects
- Metabolism, Diabetes, and Cancer
Seoul National University Children's Hospital
2023
Seoul National University
2023
Amorepacific (South Korea)
2013-2021
Gyeonggi Research Institute
2020
Government of the Republic of Korea
2020
Korea Evaluation Institute of Industrial Technology
2020
Soonchunhyang University
2015
Changwon National University
2013-2014
Chonnam National University
2011
University of Georgia
2011
Contractile vacuole complexes are critical components of cell volume regulation and have been shown to other functional roles in several free-living protists. However, very little is known about the functions contractile complex parasite Trypanosoma cruzi, etiologic agent Chagas disease, than a role osmoregulation. Identification protein composition these organelles important for understanding their physiological roles. We applied combined proteomic bioinfomatic approach identify proteins...
Transient receptor potential vanilloid subfamily, member 1 (TRPV1) may play an important role in pruritus and inflammation induction atopic dermatitis (AD). The treatment effect of TRPV1 antagonist via topical application patients with AD remains unknown.To assess the clinical efficacy safety PAC-14028, a antagonist, AD.In this 8-week, phase IIb, randomized, double-blind, multicentre, vehicle-controlled study, mild-to-moderate were randomized to receive PAC-14028 cream 0·1%, 0·3%, 1·0% or...
Compound K (CK) is one of the major metabolites ginsenosides exhibiting a variety pharmacological properties such as anti-ageing, anti-oxidation and anti-inflammatory activities. However, protective efficacy CK in abnormal skin conditions with inflammatory responses was not examined. Here, we investigated effects on matrix metalloproteinase-1 (MMP-1) type I procollagen production tumor necrosis factor-α (TNF-α)-stimulated human fibroblasts HS68 cells equivalents. We found that suppressed...
Abstract BACKGROUND Water soluble polysaccharide derived from green tea (WSP) is produced as byproducts when catechins were extracted tea. Although inhibitory effect of on the glucose transport in small intestine has been studied, hypoglycemic efficacy WSP or its combinational not studied. In order to investigate with extract (GTE), co‐consumption GTE and wheat starch was investigated using vitro digestion coupled Caco‐2 cells. The mechanism intestinal elucidated throughout gene expression...
Aloe products are one of the top selling health-functional foods in Korea, however adequate level intake to achieve desirable effects not well understood. The objective this study was determine intestinal uptake and metabolism physiologically active aloe components using vitro absorption model. Caco-2 cell monolayer everted gut sac were incubated with 5-50 microM aloin, aloe-emodin, aloesin. basolateral appearance test compounds their glucuronosyl or sulfated forms quantified HPLC. % aloesin...
Melanogenesis is essential for the protection of skin against UV, but excessive production melanin causes unaesthetic hyperpigmentation. Much effort being made to develop effective depigmenting agents. Here, we found that a tyrosinase inhibitor, AP736 (5-adamantan-1-yl-N-(2,4-dihydroxy-benzyl)-2,4-dimethoxy-benzamide) potently suppresses expression, and mechanism underlying was elucidated. attenuated induced by diverse melanogenic stimuli in murine human melanocytes. It suppressed expression...
Trillions of microorganisms reside in the hosts' gut. Since diverse activities gut microbiota affect health status, maintenance is important for maintaining human health. Green tea (GT) has multiple beneficial effects on energy metabolism with antiobesity, antidiabetic, and hypolipidemic properties. As GT contains a large amount bioactive ingredients (e.g., catechins), which can be metabolized by microorganisms, it would feasible that consumption may cause compositional changes microbiota,...
Numerous medications are used to treat hyperpigmentation. However, several reports have indicated that repeated application of some agents, such as rhododendrol (RD), raspberry ketone (RK) and monobenzone (MB), can be toxic melanocytes. Although these agents had severe side effects in human trials, no current vitro methods predict the safety drugs. This study assessed five depigmentary compounds including leukoderma-inducing agents. In particular, we determined different concentrations...
Anthocyanins have been shown to inhibit cancer cell growth by suppressing oxidative stress and inflammatory responses. The purpose of this study was investigate the effects an anthocyanin-rich extract (AE) from black soybean coat on intestinal carcinogenesis.Apc (Min/+) mice were fed a diet 0.2% or 0.5% AE for 7 weeks. We analyzed number tumors, markers associated with β-catenin cytosolic phospholipase A2 (cPLA2) signals. cellular expression determined.The tumors significantly lower in...
Abstract Airborne fine dust particles (FDPs) have been identified as major toxins in air pollution that threaten human respiratory health. While searching for an anti-FDP reagent, we found green tea extract (GTE) and fractions rich flavonol glycosides (FLGs) crude polysaccharides (CTPs) had protective effects against FDP-stimulated cellular damage the BEAS-2B airway epithelial cell line. The GTE, FLGs, CTPs significantly increased viability lowered oxidative stress levels FDP-treated cells....
Purpose: Ethyl pyruvate has anti-inflammatory properties and protects organs from ischemia/reperfusion (I/R)-induced tissue injury.The aim of this study was to determine whether ethyl decreases the inflammatory response after regional I/R injury against delayed in an vivo rat heart model a 24 hours reperfusion.Materials Methods: Rats were randomized receive lactated Ringer's solution or dissolved solution, which given by intraperitoneal injection 1 hour prior ischemia.Rats subjected 30 min...
The purpose of the current study was to investigate effect green tea ethanol extract (GTE) and polysaccharide fractions from (PFGs) on hydrolysis wheat starch, microstructural changes, intestinal transport glucose. amount resistant starch (RS) significantly lowered in water-soluble (WSP), polysaccharide-pectinase (WSP-P), water-insoluble polysaccharide-alkali soluble (WISP-Alk-Soluble; p < 0.05). microstructures gelatinized granules with WSP, WSP-P, WISP-Alk-Soluble were spherical small...
RNA electroporation as a gene delivery method is more feasible and safer compared with viral vectors. RNA-loaded dendritic cells (DC) have been used to induce T cell responses against tumor rejection antigens B can also act antigen-presenting for cellular vaccines. In this study, we DC, after carcinoembryonic antigen (CEA) RNA, their capacity generate cytotoxic lymphocytes antitumor immunity. Vaccination using these induced levels of IFN-gamma-secreting comparable those by DC. Intravenous...
The hypothesis of the current study was that flavonol and polysaccharides obtained during catechins extraction from green tea may enhance effect on preventing pancreatic lipase activity, free glycerol absorption accumulation in adipocytes co-cultured with Caco-2 cell after vitro digestion. Catechins rich extract (GCT: 10 mg), GCT formulated (GTP: 1 mg) (GFV: 0.1 strongly inhibited activity digestion while increasing lipolysis adipocytes. Lipid significantly reduced (10 + GTP (1 GFV...
The aim of this study was to profile the bioaccessibility and intestinal absorption epicatechins flavonols in different forms green tea its formulation: loose leaf tea, powdered 35% catechins containing GTE, GTE formulated with tea-derived polysaccharide (CATEPLUS™). bioaccessibillity investigated by using an vitro digestion model system Caco-2 cells. total CATEPLUS™ 1.27%, 2.30%, 22.05%, 18.72%, respectively, showing that had significantly higher than tea. None were detected but 85.74%...
Aloin is a physiologically active anthraquinone present in aloe.There are two isomers of aloin, aloin A and B, occurring as mixture diastereomers.The objective this study was to determine the bioavailability tissue distribution aloin.Rats were gavaged with 11.8g/kg levels its conjugates measured plasma, tissues, urine.Plasma level showed peak at 1hr after administration concentration 59.07±10.5 ng/ml.The 24 h cumulated urinary 0.03% initial dose.These results suggest that absorbed reaches...
Abstract Background: Serum cystatin B (CSTB) concentrations have been reported to be increased in patients with hepatocellular carcinoma compared seen normal subjects. In this study, we developed a “fluorescent microsphere immunoassay” (FMI) capable of specifically detecting CSTB serum. Methods: The FMI used microparticle conjugated polyclonal antibody and biotinylated monoclonal as capture protein probe protein, respectively. results were obtained using the Bio-Plex 200 system. Results:...
Results from the current study suggested that whole green tea components rich in flavonols and polysaccharides could be potential hypoglycemic excipient ingredients into catechins by enhancing catechin absorption.