A5067087154- Hearing Loss and Rehabilitation
- Plant Disease Resistance and Genetics
- Hearing, Cochlea, Tinnitus, Genetics
- Horticultural and Viticultural Research
- Vestibular and auditory disorders
- Fermentation and Sensory Analysis
- Wheat and Barley Genetics and Pathology
- Chromosomal and Genetic Variations
- Genetic and Environmental Crop Studies
- Genomics and Phylogenetic Studies
- Plant biochemistry and biosynthesis
- Plant nutrient uptake and metabolism
- Legume Nitrogen Fixing Symbiosis
- Plant Reproductive Biology
- Agricultural pest management studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuroscience and Music Perception
- Musculoskeletal synovial abnormalities and treatments
- Genetics and Plant Breeding
- Genetic Mapping and Diversity in Plants and Animals
- Noise Effects and Management
- Plant Physiology and Cultivation Studies
- Plant Parasitism and Resistance
- Cerebral Venous Sinus Thrombosis
- Occupational Health and Performance
Helmholtz Zentrum München
2019-2025
Technical University of Munich
2024-2025
Misr University for Science and Technology
2025
Ain Shams University
2003-2024
HolsboerMaschmeyer NeuroChemie (Germany)
2024
Tohoku University
2022
Kazusa DNA Research Institute
2022
Center for Environmental Health
2022
Bielefeld University
2017-2019
National Institute of Cardiovascular Diseases
2014
Abstract Genetic diversity is key to crop improvement. Owing pervasive genomic structural variation, a single reference genome assembly cannot capture the full complement of sequence species (known as ‘pan-genome’ 1 ). Multiple high-quality assemblies are an indispensable component pan-genome infrastructure. Barley ( Hordeum vulgare L.) important cereal with long history cultivation that adapted wide range agro-climatic conditions 2 . Here we report construction chromosome-scale for...
Cultivated oat (Avena sativa L.) is an allohexaploid (AACCDD, 2n = 6x 42) thought to have been domesticated more than 3,000 years ago while growing as a weed in wheat, emmer and barley fields Anatolia1,2. Oat has low carbon footprint, substantial health benefits the potential replace animal-based food products. However, lack of fully annotated reference genome hampered efforts deconvolute its complex evolutionary history functional gene dynamics. Here we present high-quality A. close...
Abstract A pan-transcriptome describes the transcriptional and post-transcriptional consequences of genome diversity from multiple individuals within a species. We developed barley using 20 inbred genotypes representing domesticated by generating analyzing short- long-read RNA-sequencing datasets tissues. To overcome single reference bias in transcript quantification, we constructed genotype-specific (RTDs) integrated these into linear pan-genome framework to create pan-RTD, allowing...
Abstract The diversity of maize ( Zea mays ) is the backbone modern heterotic patterns and hybrid breeding. Historically, US farmers exploited this variability to establish today’s highly productive Corn Belt inbred lines from blends dent flint germplasm pools. Here, we report de novo genome sequences four European assembled pseudomolecules with scaffold N50 ranging 6.1 10.4 Mb. Comparative analyses two explains pronounced differences between both germplasms. While overall syntenic order...
Abstract Under-utilised orphan crops hold the key to diversified and climate-resilient food systems. Here, we report on crop genomics using case of Lablab purpureus (L.) Sweet (lablab) - a legume native Africa cultivated throughout tropics for forage. Our Africa-led plant genome collaboration produces high-quality chromosome-scale assembly lablab genome. highlights organisation trypsin inhibitor genes an important anti-nutritional factor in lablab. We also re-sequence wild accessions from...
Pangenomes are collections of annotated genome sequences multiple individuals a species
Abstract Lotus japonicus is a herbaceous perennial legume that has been used extensively as genetically tractable model system for deciphering the molecular genetics of symbiotic nitrogen fixation. Our aim to improve L. reference genome sequence, which so far based on Sanger and Illumina sequencing reads from accession MG-20 contained large fraction unanchored contigs. Here, we use long PacBio Gifu combined with Hi-C data new high-density genetic maps generate high-quality chromosome-scale...
SUMMARY Wind, rain, herbivores, obstacles, neighbouring plants, etc. provide important mechanical cues to steer plant growth and survival. Mechanostimulation stimulate yield stress resistance of crops is significant research interest, yet a molecular understanding transcriptional responses touch largely absent in cereals. To address this, we performed whole‐genome transcriptomics following mechanostimulation wheat, barley, the recent genome‐sequenced oat. The largest transcriptome changes...
Pangenomes are collections of annotated genome sequences multiple individuals a species. The structural variants uncovered by these datasets major asset to genetic analysis in crop plants. Here, we report pangenome barley comprising long-read sequence assemblies 76 wild and domesticated genomes short-read data 1,315 genotypes. An expanded catalogue variation the includes structurally complex loci that have become hot spots gene copy number evolutionarily recent times. To demonstrate utility...
Abstract A pan-transcriptome describes the transcriptional and post-transcriptional consequences of genome diversity from multiple individuals within a species, revealing an assortment functions that drive biological outcomes. We developed barley using twenty inbred genotypes representing domesticated* by generating analysing extensive short- long-read RNA sequencing datasets tissues. To overcome single reference bias facilitate downstream analyses we constructed genotype-specific transcript...
Fifty to eighty percent of autosomal recessive deafness is due mutations in the GJB2 gene encoding connexin 26. Among Caucasians, c.35delG mutation this accounts for up 30 70% all cases with early childhood deafness. In study, we present analysis 159 Egyptians from 111 families non-syndromic mild profound hearing impairment. An additional family Vohwinkel syndrome, a combination impairment and palmoplantar keratoderma constriction digits, was also included. We used direct sequencing detect...
AbstractTo determine if there are racial differences in the prevalence of spontaneous otoacoustic emissions (SOAEs), both ears 20 Negro, Asian and Caucasian subjects were examined for presence SOAEs. Within each group, equal numbers normally hearing males females tested. Significant occurrence SOAEs found between three groups, with Negroes expressing more than Caucasians, Asians demonstrating an intermediate number these emissions. In support previous observations, recorded from female male...
Congenital hearing impairment in infants and children has been linked with lifelong deficits speech language acquisition, poor academic performance, personal-social maladjustments, emotional difficulties. Great emphasis is placed on the importance of early detection, reliable diagnosis, timely intervention better chances impaired developing skills equivalent to their peers. This article describes long journey that newborn screening process passed through developed countries. It also...
Grapevine (Vitis vinifera) is one of the most important perennial crop plants in worldwide. Understanding developmental processes like flowering, which impact quality and quantity yield this species therefore high interest. This gets even more when considering some expected consequences climate change. Earlier bud burst for example, may result loss due to spring frost. Berry ripening under higher temperatures will wine quality. Knowledge interactions between a genotype or allele combination...
Auditory brain stem response (ABR) and middle latency (MLR] were recorded in 49 epileptic patients. Responses evoked at 90 dB nHL down to threshold. A statistically significant number of patients showed elevated ABR (30.1%] MLR (40.7%) thresholds, even though their puretone audiograms normal hearing sensitivity. Threshold elevation was more frequent subjects with grand mal epilepsy compared temporal lobe reflecting poorer the former subgroup. Furthermore, chronicity illness significantly...
Abstract The exceptional diversity of maize ( Zea mays ) is the backbone modern heterotic patterns and hybrid breeding. Historically, US farmers exploited this variability to establish today’s highly productive Corn Belt inbred lines from blends dent flint germplasm pools. Here, we report high quality de novo genome sequences four European EP1, F7, DK105 PE0075 assembled pseudomolecules with scaffold N50 ranging between 6.1 10.4 Mb. Comparative analyses two genomes B73 PH207 elucidates...
Abstract Orphan crops (also described as underutilised and neglected crops) hold the key to diversified climate-resilient food systems. After decades of neglect, genome sequencing orphan is gathering pace, providing foundations for their accelerated domestication improvement. Recent attention has however turned gross under-representation researchers in Africa efforts indigenous crops. Here we report a radically inclusive approach crop genomics using case Lablab purpureus (L.) Sweet (syn....
Visual vestibular mismatch (VVM) is a group of symptoms rather than disease. All are exaggerated by introducing any visual conflict. For such reason, there no adequate tools to investigate or diagnose and limited research studies were done explore people. To identify VVM disorder among dizzy patients study the function in them. This was conducted on 30 suffering from (out 153 patients) who selected questionnaire modified authors based original questionnaire. subjected objective testing...
A total number of 68 cochlear implant recipients were evaluated retrospectively. They 20 adults implanted in right ear, matched left ear while 14 children and ear.
Oat grain is a traditional human food rich in dietary fiber that contributes to improved health. Interest the crop has surged recent years owing its use as basis for plant-based milk analogs. an allohexaploid with large, repeat-rich genome was shaped by subgenome exchanges over evolutionary timescales. In contrast many other cereal species, genomic research oat still at early stage, and surveys of structural diversity gene expression variability are scarce. Here, we present annotated...
Abstract Background Hearing impaired patients often report difficulties on attending to auditory message. These are not only exclusive understanding the message, rather, process itself become effortful and induce tiredness or fatigue. While conventional Puretone audiometry speech efficient tools access hearing individuals, they do address perceived Listening Effort (LE) that patient faces daily basis. Accordingly, LE assessment represent a relatively new dimension in evaluating population....