A5014901070- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Reproductive Health and Technologies
- Prenatal Screening and Diagnostics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cryospheric studies and observations
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Renal and related cancers
- MicroRNA in disease regulation
- RNA modifications and cancer
- Soil Moisture and Remote Sensing
- RNA Research and Splicing
- Liver physiology and pathology
- Cancer-related gene regulation
- Landslides and related hazards
- Plant biochemistry and biosynthesis
- Leptospirosis research and findings
- Plant Gene Expression Analysis
- Organ Donation and Transplantation
- COVID-19 Impact on Reproduction
- Nerve injury and regeneration
- Reproductive biology and impacts on aquatic species
- HVDC Systems and Fault Protection
- Reproductive Physiology in Livestock
- Advanced SAR Imaging Techniques
Central South University
2011-2025
Reproductive & Genetic Hospital CITIC-Xiangya
2019-2025
Institute of Genetics and Developmental Biology
2018-2024
Chinese Academy of Sciences
2018-2024
Aerospace Information Research Institute
2022-2024
University of Chinese Academy of Sciences
2019-2024
WuXi AppTec (China)
2024
Aarhus University Hospital
2024
Wuhan University
2021
Xiangya Hospital Central South University
2011
The formation of long-term memory is critical for learning ability and social behaviors humans animals, yet its underlying mechanisms are largely unknown. We found that the efficacy hippocampus-dependent consolidation regulated by METTL3, an RNA N6-methyladenosine (m6A) methyltransferase, through promoting translation neuronal early-response genes. Such effect exquisitely dependent on m6A methyltransferase function METTL3. Depleting METTL3 in mouse hippocampus reduces ability, unimpaired...
This study presents experimental investigations of the flexural bearing capacity lower load-bearing structures pull-up cantilever scaffolds with adjustable steel tie rods. First, three different specifications are tested to analyze their primary failure modes and mechanisms. The results then simulated validated using a finite element analysis (FEA) method. Subsequently, an extended parametric is performed numerically, simplified calculation formula derived through nonlinear curve fitting...
Spermatogonial stem cells (SSCs) are essential for initiating and maintaining normal spermatogenesis, notably, they have important applications in both reproduction regenerative medicine. Nevertheless, the molecular mechanisms controlling fate determinations of human SSCs remain elusive. In this study, we identified a selective expression APBB1 dormant SSCs. We demonstrated first time that interacted with KAT5, which led to suppression GDF15 consequent inhibition SSC proliferation....
Abstract Recent studies have shown that shorter periods of ejaculatory abstinence may enhance certain sperm parameters, but the molecular mechanisms underlying these improvements are still unclear. This study explored whether reduced could improve semen quality, particularly for use in assisted reproductive technologies (ART). We analyzed samples from men with normal counts ( n = 101) and those low motility or concentration 53) after 3–7 days then 1–3 h abstinence, obtained Reproductive...
Abstract Simultaneous dysregulation of multiple microRNAs (miRs) affects various pathological pathways related to cardiac failure. In addition being potential disease-specific markers, miR-23b/27b/24-1 were reported be responsible for conferring pathophysiological processes. this study, we identified a conserved guanine-rich RNA motif within the cluster that can form an G-quadruplex (rG4) in vitro and cells. Disruption intragenic rG4 significantly increased production all three miRs....
Spermatogonial stem cells (SSCs) are the initial for spermatogenesis. Although much progress has been made on uncovering a number of modulators SSC fate decisions in rodents, genes mediating human SSCs remain largely unclear. Here we report, first time, that TCF3, member basic helix-loop-helix family transcriptional modulator proteins, can stimulate proliferation and suppress apoptosis through targeting podocalyxin-like protein (PODXL). TCF3 was expressed primarily GFRA1-positive...
The model-based inversion of spaceborne polarimetric interferometric synthetic aperture radar (PolInSAR) has great potential for large-scale forest height estimation. performance strongly depends on the accurate estimation ground phase and volume coherence, these aspects still need to be addressed due double-candidate effect phase. This paper introduces a maximum posteriori method based two-layer randomly oriented over model achieve more Firstly, components from different polarizations are...
Slow freezing is the most commonly used technique for cryopreservation of spermatozoa in clinical practice. However, it has been shown to have a negative impact on sperm function and structure. Vitrification as successful alternative method proved better protective effects human embryos, but vitrification still subject low recovery rates. In this study, modified native was developed. A total 28 semen samples were included; each sample divided into three equal parts assigned fresh, slow...
Spermatogonial stem cells (SSCs) are the origin of male spermatogenesis, which can reconstruct germ cell lineage in mice. However, application SSCs for fertility restoration is hindered due to unclear mechanisms proliferation and self-renewal humans.To investigate role mechanism SPOC domain-containing protein 1 (SPOCD1) human SSC proliferation.We analyzed publicly available testis single-cell RNA sequencing (RNA-seq) data found that SPOCD1 predominantly expressed early developmental stages....
The global practice of cryopreservation human semen is commonplace in Assisted Reproductive Technology (ART) labs and sperm banks. However, information on the effects long-term limited to clinical data summaries descriptions. For this study, we prepared 4 specimens fresh semen, cryostored for at least 1 year, 3 5 years, 10 15 years. Total RNA was extracted from each sample, amplified, labeled, mapped known primary microRNA (miRNA) miRBase database, enabling prediction novel miRNAs. We found...
Cassava is susceptible to mites, especially Tetranychus cinnabarinus. Secondary metabolism products such as flavonoids play an important role antimicrobial metabolites protecting plants against biotic stressors including fungal, pathogen, bacterial, and pest defense. The chalcone synthase (CHS) the initial step of phenylpropanoid pathway for producing gatekeeper pathway. Until recently, CHS genes family has not been systematically studied in cassava. Thirty-nine were identified from cassava...
In this paper, we introduce a refined three-stage inversion algorithm (TSIA) for forest height estimation using polarimetric interferometric synthetic aperture radar (PolInSAR). Specifically, the iterative extraction of boundary coherence region (IEBCR) and look-up table (ILUT) are proposed to improve efficiency traditional TSIA. A class TSIA utilizes (BCR) alleviate underestimation phenomenon in estimation. Given many eigendecompositions BCR (EBCR), analyze relationship eigenvectors between...
Radargrammetry is a widely used methodology to generate the large-scale Digital Surface Model (DSM). Stereo matching most challenging step in radargrammetry due significant geometric differences and inherent speckle noise. The noise results grayscale of same feature points, which makes traditional Horn–Schunck (HS) flow or multi-window zero-mean normalized cross-correlation (ZNCC) methods degrade. Therefore, this paper proposes an algorithm named Epipolar HS-NCC Flow (EHNF) for dense stereo...
Cyclophosphamide (CYP)-induced cardiotoxicity is a common side effect of cancer treatment. Although it has received significant attention, the related mechanisms CYP-induced remain largely unknown. In this study, we used cell and animal models to investigate CYP on cardiomyocytes. Our data demonstrated that prolonged cardiac QT interval electromechanical coupling time courses accompanied by JPH2 downregulation. Moreover, N6-methyladenosine (m6A) methylation sequencing RNA suggested induced...
Is vacuolization in embryos on Days 3 and 4 associated with parent-related factors, stimulation protocols, embryo development, ploidy, pregnancy neonatal outcomes?This is a retrospective cohort study that comprised 5,703 from 611 patients who underwent preimplantation genetic testing time-lapse monitoring of their August 2017 to September 2021.Embryo the LH level day hCG trigger number retrieved oocytes. Compared vacuole-negative embryos, rates blastocyst formation good-blastocyst was...
Human spermatogonial stem cells (SSCs) are the basis of spermatogenesis. However, little is known about developmental regulatory mechanisms SSC due to sample origin and species differences.To investigates involved in proliferation human SSC.The expression mitogen-activated protein kinase 7 (MKK7) testis was identified using immunohistochemistry western blotting (WB). MKK7 knocked down small interfering RNA, cell apoptosis were detected by WB, EdU, counting kit-8 fluorescence-activated...
Pericentric inversion of chromosome 9 (inv[9]) is a common chromosomal structural variant, but its impact on clinical outcomes remains debated. The screening criteria sperm banks are rarely mentioned to individuals with inv(9). In this study, we evaluated the fertility donors inv(9) who met eligibility for (inv[9]-eligible donors). From March 2004 May 2022, analysis 16 124 at CITIC-Xiangya Human Sperm Bank in Hunan Province (Changsha, China) found that 251 (1.6%) had variations, being most...
This paper presents a method for extracting the digital elevation model (DEM) of forested areas from polarimetric interferometric synthetic aperture radar (PolInSAR) data. The models ground phase as Von Mises distribution, with mean topographic computed an external DEM. By combining prior distribution complex Wishart observation covariance matrix, we derive maximum posterior (MAP) inversion based on RVoG and analyze its Cramer–Rao Lower Bound (CRLB). Furthermore, considering characteristics...