A5101918150- Genetic and Kidney Cyst Diseases
- Additive Manufacturing Materials and Processes
- Biomedical Research and Pathophysiology
- Viral gastroenteritis research and epidemiology
- Advanced MEMS and NEMS Technologies
- Particle Dynamics in Fluid Flows
- Escherichia coli research studies
- Ultrasonics and Acoustic Wave Propagation
- Bacteriophages and microbial interactions
- Bone health and treatments
- Genetic Syndromes and Imprinting
- Advanced biosensing and bioanalysis techniques
- Parathyroid Disorders and Treatments
- Hedgehog Signaling Pathway Studies
- Water Systems and Optimization
- Bone Metabolism and Diseases
- Acoustic Wave Resonator Technologies
- Gut microbiota and health
- Advanced Materials and Mechanics
- Clostridium difficile and Clostridium perfringens research
- Epigenetics and DNA Methylation
- Pharmacological Effects and Toxicity Studies
- Electrochemical sensors and biosensors
- Additive Manufacturing and 3D Printing Technologies
- Electric Power System Optimization
Changchun University of Science and Technology
2022-2023
Suzhou Institute of Nano-tech and Nano-bionics
2022
Chinese Academy of Sciences
2022
Vaughn College of Aeronautics and Technology
2022
Nanjing University of Aeronautics and Astronautics
2022
South China University of Technology
2022
University of Kansas Medical Center
2005-2022
University of Shanghai for Science and Technology
2022
University of Technology
2022
Peking University
2021
We examined the osteoblast/osteocyte expression and function of polycystin-1 (PC1), a transmembrane protein that is component polycystin-2 (PC2)-ciliary mechano-sensor complex in renal epithelial cells. found MC3T3-E1 osteoblasts MLO-Y4 osteocytes express transcripts for PC1, PC2, ciliary proteins Tg737 Kif3a. Immunohistochemical analysis detected cilia-like structures osteoblastic osteocyte-like cell lines as well primary from calvaria. Pkd1m1Bei mice have inactivating missense mutations...
Integrating sense in a thin artificial muscle fiber for environmental adaption and actuation path tracing, as snail tentacle does, is highly needed but still challenging because of the interfacing mismatch between fiber's sensing components. Here, we report an neuromuscular by wrapping carbon nanotube (CNT) core sequence with elastomer layer, nanofiber network, MXene/CNT sheath, achieving ingenious sense-judge-act intelligent system elastic fiber. The CNT/elastomer components provide...
PKD1 (polycystin-1), the disease-causing gene for ADPKD, is widely expressed in various cell types, including osteoblasts, where its function unknown. Although global inactivation of Pkd1 mice results abnormal skeletal development, presence polycystic kidneys and perinatal lethality confound ascertaining direct osteoblastic functions adult bone. To determine role we conditionally inactivated postnatal mature osteoblasts by crossing Oc (osteocalcin)-Cre with floxed (Pkd1(flox/m1Bei)) to...
Runx2 controls the commitment of mesenchymal cells to osteoblastic lineage. Distinct promoters, designated P1 and P2, give rise functionally similar Runx2-II Runx2-I isoforms. We postulate that this dual promoter gene structure permits temporal spatial adjustments in amount isoforms necessary for optimal bone development. To evaluate dose-dependent effect on development, we intercrossed selective Runx2-II(+/-) with nonselective Runx2-II(+/-)/Runx2-I(+/-) mice create compound mutant mice:...
Polycystin-1 (PC1) may play an important role in skeletogenesis through regulation of the bone-specific transcription factor Runx2-II. In current study we found that PC1 co-localizes with calcium channel polycystin-2 (PC2) primary cilia MC3T3-E1 osteoblasts. To establish Runx2-II mediating effects on bone, crossed heterozygous Pkd1m1Bei and mice to create double (Pkd1+/m1Bei/Runx2-II+/-) deficient both Pkd1+/m1Bei/Runx2-II+/- exhibited additive reductions expression was associated impaired...
Piezoelectric micromechanical ultrasonic transducers (pMUTs) are new types of distance sensors with great potential for applications in automotive, unmanned aerial vehicle, robotics, and smart homes. However, previously reported pMUTs limited by a short sensing due to lower output sound pressure. In this work, pMUT special dual-ring structure based on scandium-doped aluminum nitride (ScAlN) is proposed. The combination pinned boundary conditions high piezoelectric performance ScAlN film...
Abstract In this paper, a hybrid improved particle swarm optimization (IPSO) algorithm is proposed for the of hydroelectric power scheduling in multi-reservoir systems. The conventional (PSO) two ways: (1) linearly decreasing inertia weight coefficient (LDIWC) replaced by self-adaptive exponential (SEIWC), which could make PSO more balanceable and effective both global local searches. (2) crossover mutation idea inspired genetic (GA) imported into updating method to enhance diversity...
Studies in rodents with reduced nephron mass have suggested a strong positive correlation between dietary phosphate consumption and CKD progression. Prior work by our group demonstrated that restriction can prevent tubular injury microcyst formation glomerulonephritis. Tubular cystic dilation of tubules are key contributors to kidney function decline polycystic disease (PKD). Here, we determined whether slows renal cyst growth fibrosis mouse model PKD. Pcy/pcy mice received normal (0.54%) or...
Recent evidence suggests the systemic accumulation of by-products gut microbes contributes to cardiovascular morbidity in patients with CKD. Limiting generation toxic bacterial by manipulating intestinal microbiota may be a novel strategy for reducing disease Rifaximin is minimally absorbed, oral antibiotic that targets pathogens and commonly used as chronic therapy prevention encephalopathy cirrhosis.We conducted randomized, double-blinded, placebo-controlled trial determine effect 10-day...
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst growth and a loss of functioning renal mass, but decline in glomerular filtration rate (GFR) onset end-stage (ESRD) occur late the course. There therefore great need for early prognostic biomarkers this disorder.We measured baseline serum fibroblast factor 23 (FGF23) levels 192 patients with ADPKD from Consortium Radiologic Imaging Studies PKD (CRISP) cohort that were followed median 13 years tested...
Cyclophosphamide (CYP)-induced cardiotoxicity is a common side effect of cancer treatment. Although it has received significant attention, the related mechanisms CYP-induced remain largely unknown. In this study, we used cell and animal models to investigate CYP on cardiomyocytes. Our data demonstrated that prolonged cardiac QT interval electromechanical coupling time courses accompanied by JPH2 downregulation. Moreover, N6-methyladenosine (m6A) methylation sequencing RNA suggested induced...
A simple and sensitive method was developed for determining ivermectin in sheep serum. The sample is cleaned up on an immunoaffinity column determined by liquid chromatography with detection at 245 nm. Recoveries ranged from 90.3 to 98.8% (93.9 +/- 4.3%) samples fortified 2.0-50 ng ivermectin/mL. Coefficients of variation were 3.2-11.0%. limit 1 ng/mL 5.0 mL
Diarrheagenic Escherichia coli (DEC) can cause epidemic diarrhea worldwide. The pathogenic potential of different strains is diverse and the continuous emergence has brought serious harm to public health. Accurately distinguishing identifying DEC with virulence necessary for epidemiological surveillance investigation. Clustered regularly interspaced short palindromic repeats (CRISPR) typing a new molecular method that distinguish bacteria excellently shown great promise in typing. purpose...
Compound heterozygous Pkd1 V/RC mice were found to form calcium phosphate-containing stones within cysts of the renal cortex by 13 wk age. This is first polycystic kidney disease animal model exhibiting spontaneous stone formation. A growing body evidence suggests a link between formation and cystic disease. mouse may be useful for studying interplay cyst functional role polycystins in mineral homeostasis.
Shiga toxin-producing Escherichia coli (STEC) is an important food-borne pathogen, which can cause diseases such as diarrhea, hemorrhagic enteritis, and hemolytic uremic syndrome in humans. Twelve STEC isolates were collected from beeves feces of commercial animals China between 2019 2020 for this study. In addition to the determination serotype toxin subtype, whole-genome sequencing (WGS) was used determining phylogenetic relationships, antimicrobial resistance (AMR), virulence genes,...
Introduction Trimethylamine‐n‐oxide (TMAO) is a byproduct of intestinal bacteria metabolism choline and L‐carnitine. In patients with chronic kidney disease (CKD), TMAO accumulates in the bloodstream thought to perpetuate fibrosis promote cardiovascular (CVD). We hypothesized that rifaximin, broad‐spectrum oral antibiotic poor bioavailability, would significantly lower serum levels slow progression CKD mice. Design mice were generated by feeding C57BL/6J diet containing 0.2% adenine; non‐CKD...
Abstract A 3D whole size numerical model of a ring type coaxial nozzle was established to obtain particle space trajectory and convergence character. The realizable k-ε applied in the gas flow phase; powder coupled by Euler-Lagrange approach as discrete phase model. Different material range were chosen calculate concentration distribution. simulated stream morphology good agreement with experimental results high-speed camera observations. Simulating show that using mean diameter...