A5103073554- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Parathyroid Disorders and Treatments
- Advanced Glycation End Products research
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Medical Imaging and Pathology Studies
- Renal and Vascular Pathologies
- Natural Antidiabetic Agents Studies
- Metabolism and Genetic Disorders
- Kidney Stones and Urolithiasis Treatments
- Endoplasmic Reticulum Stress and Disease
- Alcohol Consumption and Health Effects
- Machine Learning in Healthcare
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Oral Health Pathology and Treatment
- Biomarkers in Disease Mechanisms
- Hemodynamic Monitoring and Therapy
- Peer-to-Peer Network Technologies
- Cardiovascular Function and Risk Factors
- Acute Kidney Injury Research
- Problem and Project Based Learning
- Erythropoietin and Anemia Treatment
- Health, Environment, Cognitive Aging
Zhongda Hospital Southeast University
2001-2024
Southeast University
2023
Southeast University
2006-2018
Taipei Medical University
2013
National Yang Ming Chiao Tung University
2013
Nantong University
2010
Jiangyin People's Hospital
2010
Affiliated Hospital of Nantong University
2010
Robert Gordon University
2004
University of Science and Technology of China
2002
Oxidative stress plays a critical role in the pathogenesis of diabetic nephropathy (DN). p66shc is closely related to oxidative stress. However, exact mechanism its involvement poorly understood. This study aimed investigate p66shc-related pathway nephropathy.In an in-vivo experiment, rats were injected with streptozotocin induce early nephropathy. The treatment groups aminoguanidine group and enzastaurin group. In in-vitro human renal proximal tubule epithelial cells (HK-2 cells) cultured...
Aquaporin 4 (AQP4) is a type of water channel protein that maintains the balance cardiomyocytes. However, physiological role AQP4 in cardiovascular disease poorly understood. We wanted to explore whether p66Shc and endoplasmic reticulum stress participates knockout (KO)-mediated cardiac injury. There were two types mice: wild-type mice. Each was randomly divided into three groups: Control group, isoprenaline stimulation group (ISO, 1 mg/kg, s.c., 5 days), apocynin treatment (APO, 100 p.o., 3...
Abstract Vascular calcification (VC) is a common complication of chronic kidney disease (CKD), for which no effective therapies are available. Hyperphosphatemia, feature CKD, well-known inducer VC. High phosphate (HP)-induced ferroptosis plays crucial role in CKD-related VC (CKD-VC), but the mechanisms remain unclear. Lipocalin-2 (LCN2), an iron-trafficking protein, has been implicated regulation. In present study, LCN2 as potential mediator CKD-VC was investigated. HP-induced expression...
For the standard spoken Chinese dialect commonly known as Putonghua or Mandarin, a large corpus called USTC95 (University of Science and Technology China, '95) is introduced, which primarily designed to support research in speech recognition analysis system evaluation. This consists four major sub-corpora, corresponding isolated syllables, multi-syllable words, sentences telephone speech. With an elaborate design, encompasses all phones mono-syllables, well co-articulation effects Putonghua;...
Together with an increasingly aging world population there is also increasing prevalence of atherosclerosis. Renal artery stenosis (RAS) one the systemic manifestations Its incidence about 15%-35%.1 RAS accounts for 5%-27% all patients end-stage renal disease (ESRD).2 Patients dysfunction resulting from are at risk death cardiovascular and ESRD.3 The rising, owing to diabetes atherosclerotic among our population. This poses major challenges clinicians when making diagnostic treatment...
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Background: HSK21542, a novel selective peripherally-restricted κ-opioid receptors that are proved to be safe and effective analgesic antipruritic candidate in vitro vivo studies. We aimed evaluate the safety, pharmacokinetics efficacy of HSK21542 hemodialysis patients over one-week treatment period, establish optimal dosage for further 12-week stage 2 study.Methods: In this multiple ascending dose study, were randomly assigned receive (0.05-0.80 μg/kg),or placebo three times within 2.5 h at...