A5023711063- Intestinal Malrotation and Obstruction Disorders
- Congenital gastrointestinal and neural anomalies
- Clinical Nutrition and Gastroenterology
- Gastrointestinal disorders and treatments
- Inflammatory Bowel Disease
- Diverticular Disease and Complications
- Pelvic floor disorders treatments
- Esophageal and GI Pathology
- Autoimmune and Inflammatory Disorders
- Microscopic Colitis
- Urological Disorders and Treatments
- Abdominal Surgery and Complications
- Intestinal and Peritoneal Adhesions
- Child Nutrition and Feeding Issues
- Liver Diseases and Immunity
- Infant Nutrition and Health
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Diaphragmatic Hernia Studies
- Sexual Differentiation and Disorders
- Food Allergy and Anaphylaxis Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Nuffield Health
2023
Leeds Teaching Hospitals NHS Trust
2003-2022
Great North Children's Hospital
2020
Leeds General Infirmary
2003-2017
Cincinnati Children's Hospital Medical Center
2013
Center for Children
2013
University of Cincinnati
2013
Universities UK
2008
St James's University Hospital
2005
Great Ormond Street Hospital
2001
The incidence of Crohn disease (CD) has been increasing and surgery needs to be contemplated in a substantial number cases. relevant advent biological treatment changed but not eliminated the need for many patients. Despite previous publications on indications CD, there was comprehensive review existing evidence role elective options pediatric patients affected with CD. We present an expert opinion critical literature provide evidence-based guidance manage these Indications, surgical...
Ulcerative colitis (UC) typically is associated with a confluent proctitis, whereas rectal sparing may be seen in large bowel Crohn disease (CD). A few studies have reported UC and suggested that this might indicate more severe form of the disease. This study aimed to determine prevalence prognostic significance children newly diagnosed, untreated UC.The records all presenting regional pediatric gastroenterology service between January 1996 December 2001 were retrospectively reviewed....
<h3>Abstract</h3> <b>Objective</b>: To assess the incidence of malfunction shunts in adults with spina bifida who have to control hydrocephalus. <b>Design</b>: A retrospective review medical notes and contact by questionnaire symptoms, function shunts, frequency operative procedures, follow up. <b>Subjects</b>: 110 patients attended Lord Mayor Treloar College for physically disabled between 1978 1993. <b>Results</b>: The average (range) number revisions per person was 3.6 (0-28). Although 37...
Objective To evaluate the Snodgrass procedure for patients with hypospadias who have not undergone previous surgery and whose urethral plate is too narrow tubularization alone. Patients methods Thirty‐two boys (mean age 18 months) underwent primary hypospadiac performed by one surgeon (P.S.M.). Twenty‐five had a distal (coronal, subcoronal) seven more proximal defect (penile shaft, penoscrotal). The operation involved incision of plate, which was then tubularized (Snodgrass procedure)....
Abstract Background Addition of glutamine to parenteral nutrition in surgical infants remains controversial. The aim this trial was determine whether supplementation requiring surgery would reduce the time full enteral feeding and/or decrease incidence sepsis and septicaemia. Methods A prospective double-blind multicentre randomized clinical performed less than 3 months old who required nutrition. Patients were allocated treatment or control groups by means minimization. Infants received...
For the surgical treatment of Hirschsprung's disease, several techniques are used to resect distal aganglionic colon. Two frequently Duhamel procedure and transanal endorectal pull-through procedure. During '8th Pediatric Colorectal Course' in Nijmegen, November 2015, a workshop was organized share experiences both by experts field discuss (long term) outcomes. Specifically, objective meeting main controversies relation technical execution procedures order make an initial assessment...
Infliximab is a chimeric antitumour necrosis factor (TNF) monoclonal antibody with potent anti-inflammatory effects. It highly effective in severe active and fistulating Crohn disease. The most commonly reported side effects are infections (including tuberculosis) hypersensitivity reactions; there small risk of lymphoproliferative disorders. We report the case young boy colitis who developed visual symptoms seizures postinfliximab infusion abnormal magnetic resonance imaging (MRI) brain....
Roux-en-Y jejunostomy (RYJ) permits enteral feeding in children unable to tolerate oral or intragastric feeds. It avoids many of the complications nasojejunal and gastrojejunal tubes. Here we report our experience intubated RYJ. By retrospective review patient notes from 1998 - 2003, thirty-five were identified. The median age was seven months (1 month 16 years) follow-up twenty-five 55 months). There no early postoperative deaths. eighteen (51 %) late complications: peristomal leak (6),...
Summary. Recombinant factor VIIa is licensed for use in patients with haemophilia and inhibitors. More recently it has been used as an unlicensed product adults the treatment of life threatening bleeding. However, its paediatric practice limited. We describe a series from one centre, where recombinant when conventional failed to achieve haemostasis.
Tailgut cysts, embryological remnants of the hindgut, are rare retrorectal tumours. They have been described in adults but children, especially neonates. We report a case neonate, who presented with anal stenosis and an incidental ultrasonographic finding presacral mass. Excision histological examination mass confirmed appearance tailgut cyst. There were no postoperative complications evidence recurrence over one year after excision. The clinical, pathological, radiological findings cyst...
Cytomegalovirus (CMV) is extremely rare as a cause of gastrointestinal infection in the immunocompetent child, despite high seroprevalence rate CMV general population (1,2). Where isolated cases have been reported, symptoms resolved spontaneously with time (3). We report case 12-week-old infant who was admitted acutely 10-day history diarrhea, abdominal pain, and fever; investigations suggested inflammatory bowel disease, but histological examination colonic biopsies showed typical features...
<h3>Background</h3> It is often stated that if a patient presents with 'painless rectal bleeding' then polyp the probable diagnosis. The aim of this study to review our experience children undergoing endoscopy assess above statement correct. <h3>Methods</h3> senior author keeps prospective database every child flexible sigmoidoscopy or colonoscopy. As part database, symptoms and signs with, specifically abdominal pain, diarrhoea, mucous per rectum bleeding, are recorded. These results have...
A male patient with mixed gonadal dysgenesis, involving a streak gonad on the right and histologically normal testis in left, was found to have 45, X/46, X, dic(Yp) chromosome constitution peripheral blood cultures. Fibroblasts grown from both gonads showed “normal” testicular tissue e dic(Yp), whereas cells were all X. The structure of confirmed using non‐isotopic situ hybridization Y centromere Yp specific probes. On hormonal stimulation, testosterone levels rose by 50%. left , but close...
ABSTRACT Background Ulcerative colitis (UC) typically is associated with a confluent proctitis, whereas rectal sparing may be seen in large bowel Crohn disease (CD). A few studies have reported UC and suggested that this might indicate more severe form of the disease. This study aimed to determine prevalence prognostic significance children newly diagnosed, untreated UC. Methods The records all presenting regional pediatric gastroenterology service between January 1996 December 2001 were...
The association between inflammatory bowel disease (IBD) and gastrointestinal malignancies has been well described (1,2). potential risk of malignancy is probably augmented by the use immunosuppressive therapy such as azathioprine 6-mercaptopurine (3–5). Dayharsh et al (6) reported an increased Epstein-Barr virus (EBV)–positive lymphoma in adults with IBD treated or 6-mercaptopurine. An adult Crohn (CD) taking who later developed fatal EBV infection B-cell lymphoproliferative disorder (LPD)...
INTRODUCTION Inflammatory bowel disease (IBD) presents in childhood 15% to 25% of patients (1) and is associated with a wide variety extraintestinal complications including pulmonary disease. We report child Crohn (CD) who became increasingly breathless 18 months following colectomy. Investigations showed this be due severe inflammation confirmed on biopsy CD the lung. CASE REPORT A 5-year-old boy was referred 7-month history bloody diarrhea abdominal pain together weight loss lethargy....