A5009390948- Inflammatory Myopathies and Dermatomyositis
- Vasculitis and related conditions
- Viral Infections and Immunology Research
- Eosinophilic Disorders and Syndromes
- Rheumatoid Arthritis Research and Therapies
- Muscle Physiology and Disorders
- Systemic Lupus Erythematosus Research
- Hereditary Neurological Disorders
- Celiac Disease Research and Management
- Myasthenia Gravis and Thymoma
- Cardiomyopathy and Myosin Studies
- Psoriasis: Treatment and Pathogenesis
- Heterotopic Ossification and Related Conditions
- Musculoskeletal synovial abnormalities and treatments
- Body Composition Measurement Techniques
- Liver Disease Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Infrared Thermography in Medicine
- Cystic Fibrosis Research Advances
- Spondyloarthritis Studies and Treatments
- Liver Diseases and Immunity
- Peripheral Neuropathies and Disorders
- Protein Tyrosine Phosphatases
- Neonatal Respiratory Health Research
- Orthopedic Infections and Treatments
The University of Notre Dame Australia
2019-2023
Fiona Stanley Hospital
2019-2023
Fremantle Hospital
2020
The University of Western Australia
2018-2020
Royal Perth Hospital
2015-2019
Sir Charles Gairdner Hospital
2017-2018
Center for Rheumatology
2017
Abstract Background Before the role of shear wave elastography (SWE) and B mode ultrasound (US) in diagnosis different forms idiopathic inflammatory myopathies (IIM) can be investigated, normative data is required. This study aimed to describe then compare SWE metrics muscles healthy controls patients with IIM. Methods Twenty nine adult 10 IIM (5 inclusion body myositis 5 necrotising autoimmune myopathy) underwent a full clinical examination, laboratory investigations, US measurements...
B mode ultrasound (US) and shear wave elastography (SWE) are easily accessible imaging tools for idiopathic inflammatory myopathies (IIM) but require further validation against standard diagnostic procedures such as MRI muscle biopsy.In this prospective cross-sectional study we compared US findings to biopsy in a group of 18 patients (11 F, 7 M) with active IIM (dermatomyositis 6, necrotising autoimmune myopathy 7, inclusion body myositis 4, overlap 1) who had one or both on the same muscle....
Introduction Inclusion body myositis (IBM) is a progressive inflammatory myopathy characterised by skeletal muscle infiltration and myofibre invasion CD8 + T lymphocytes. In some cases, IBM has been reported to be associated with systemic lymphoproliferative disorder of cells exhibiting highly differentiated effector phenotype known as cell Large Granular Lymphocytic Leukemia (T-LGLL). Methods We investigated the incidence T-LGL in 85 patients an aged-matched group 56 Healthy Controls (HC)....
Abstract Objectives We investigated shear wave elastography (SWE), B mode US and power Doppler (PDUS) as imaging biomarkers for longitudinal follow-up in idiopathic inflammatory myopathy (IIM), with a particular focus on immune-mediated necrotizing (IMNM) DM. Methods Participants had serial SWE, PDUS the deltoid (D) vastus lateralis (VL) muscles four occasions at intervals of 3–6 months. Clinical assessments included manual muscle testing, patient- physician-reported outcome scales. Results...
Arthritis is a common condition, and the prompt accurate assessment of hand arthritis in primary care an area unmet clinical need. We have previously developed tested screening tool combining machine-learning algorithms, to help physicians assess patients presenting with affecting hands. The aim this study was validity among number different Rheumatologists.
Up to 3% of methotrexate (MTX)-treated rheumatoid arthritis (RA) patients might develop liver fibrosis or cirrhosis, requiring effective screening algorithms.To assess the utility non-invasive assessment in RA on MTX.Fifty-six were recruited from rheumatology outpatient clinics a public tertiary centre July 2017 October 2018. Clinical data was collected. Screening for hepatic performed using transient elastography (TE), aminoaspartate transaminase platelet ratio index (APRI), Hepascore and...
Podocytopathy in systemic lupus erythematosus is characterised by diffuse foot process effacement without significant peripheral capillary wall immune deposits as seen on electron microscopy. Lupus podocytopathy falls outside the scope of current International Society Nephrology and Renal Pathology classification nephritis. We present a case relapsing with nephrotic syndrome occurring simultaneously two extra-renal serological disease flares, which makes it likely that was related to...
<h3>Background</h3> PsA can be difficult to distinguish from osteoarthritis (OA) and the treatments vary greatly. Nail involvement occur in about 15–50% patients with psoriasis<sup>1</sup>, which may aid differentiation OA. If US reliably detect nail bed changes early disease then it might helpful differentiating OA <h3>Objectives</h3> This study aims investigate seen using MRI, determine impact of on quality life (QOL). <h3>Methods</h3> Patients who fulfilled CASPAR or 1990 ACR...
Background: ANCA-associated vasculitis (AAV) is a potentially life-threatening condition for which limited Australian data are available. We investigated the clinical and epidemiological outcomes of AAV in last decade tertiary setting Western Australia (WA). Methods findings: A single centre observational study patients fulfilling classification criteria granulomatous polyangiitis (GPA), eosinophilic (EGPA) microscopic (MPA) between 2007-2016. Clinical collected at baseline, flares follow-up...
Sporadic late onset nemaline myopathy (SLONM) is a rare, intractable acquired that characterised by progressive muscle weakness and the presence of rods in myofibres. Unlike congenital form (NM), there are only few case reports series on SLONM scientific literature. We present report 62-year-old male from rural town Western Australia, without any conditions often associated with such as monoclonal gammopathy uncertain significance or HIV infection. should be considered differential diagnosis...
In inflammatory myopathies, the self-reactive immune cells involved in muscle aggression have been studied mostly using histological assessment of biopsy sections; this methodology provides advantage visualizing and identifying within tissue, but it does not allow further investigation. To gain access to live isolated cells, many studies utilized blood samples; however, absence biological tools discriminate leukocytes associated with autoimmune process from those that emerged responses...
<h3>Background</h3> ANCA- associated vasculitis (AAV) is a potentially life threatening condition requiring careful monitoring and balancing of treatment options to minimize morbidity mortality. <h3>Objectives</h3> To investigate the influence baseline disease characteristics induction therapy on course outcome in vasculitis. <h3>Methods</h3> Single centre longitudinal cohort study all adult patients with an EMEA algorithm based diagnosis AAV followed up August 2016. Clinical data including...