A5088391607- Head and Neck Cancer Studies
- Oral health in cancer treatment
- Reconstructive Surgery and Microvascular Techniques
- Effects of Radiation Exposure
- Craniofacial Disorders and Treatments
- Endoplasmic Reticulum Stress and Disease
- Facial Trauma and Fracture Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Air Quality and Health Impacts
- ERP Systems Implementation and Impact
- Cancer Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Child and Adolescent Health
- Facial Nerve Paralysis Treatment and Research
- Ethics and bioethics in healthcare
- Health Systems, Economic Evaluations, Quality of Life
Karolinska Institutet
2014-2023
Karolinska University Hospital
2014-2022
Nearly half of all cancers are treated with radiotherapy alone or in combination other treatments, where damage to normal tissues is a limiting factor for the treatment. Radiotherapy-induced adverse health effects, mostly importance cancer patients long-term survival, may appear during long time after finishing and depend on patient's radiosensitivity. Currently, there no assay available that can reliably predict individual's response radiotherapy. We profiled two study sets from breast (n =...
Abstract Background Reconstructive surgery for mandibular osteoradionecrosis is increasing; however, evidence regarding the impact on health‐related quality of life lacking. The current exploratory study prospectively investigates whether resection with reconstruction associated changes in HRQoL parameters these patients. Methods Seventeen patients underwent microvascular between 2012 and 2015, 16 completed EORTC questionnaires QLQ‐C30 QLQ‐H&N35 1 month before year after surgery. Results...
Base of tongue cancer incidence and patient survival is increasing why treatment sequelae becomes exceedingly important. Osteoradionecrosis (ORN) a late adverse effect radiotherapy brachytherapy (BT) could be risk factor. Brachytherapy used in three out six health care regions Sweden.Investigate if patients treated using BT show an increased for ORN whether has any impact on overall survival.We data from the Swedish Head Neck Cancer Register between 2008-2014. Due to nonrandomized nature...
Abstract Background Osteoradionecrosis (ORN) of the mandible is a severe complication head and neck radiotherapy (RT) treatment, where impact individual radiosensitivity has been suggested explanation. Methods A cohort patients with stage II/III ORN was compared to matched controls. Blood collected irradiated in vitro study capacity handle radiation‐induced oxidative stress. Patients were also genotyped for 8 single‐nucleotide polymorphisms (SNPs) genes involved stress response. Results...
The treatment of head and neck cancer is an intensive multimodal that has a great impact on the individual patient.This study aimed to evaluate acute long-term complications associated with mandibular resections reconstructions.We retrospectively retrieved data recurrences among patients underwent reconstructions for treating oral cavity (n = 190 patients) osteoradionecrosis (ORN, n 72). Reconstructions included composite grafts 177), soft tissue flaps 61), or primary closure without any...