A5080367673- Reconstructive Surgery and Microvascular Techniques
- Wound Healing and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Lymphatic System and Diseases
- Diagnosis and Treatment of Venous Diseases
- Streptococcal Infections and Treatments
- Surgical site infection prevention
- Pressure Ulcer Prevention and Management
- Effects of Vibration on Health
- Noise Effects and Management
- Peripheral Artery Disease Management
- Bone Tumor Diagnosis and Treatments
- Orthopedic Infections and Treatments
- Bone fractures and treatments
- Colorectal Cancer Surgical Treatments
- Sarcoma Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Trauma and Emergency Care Studies
- Soft tissue tumor case studies
- Burn Injury Management and Outcomes
- Trauma Management and Diagnosis
- Mass Spectrometry Techniques and Applications
- Hip and Femur Fractures
- Oral Health Pathology and Treatment
- Nerve Injury and Rehabilitation
Tampere University
2016-2024
Tampere University Hospital
2016-2024
Pirkanmaa Hospital District
2024
Helsinki University Hospital
2018
Urho Kaleva Kekkonen Institute
2008
Abstract According to experimental studies, low-amplitude high-frequency vibration is anabolic bone tissue, whereas in clinical trials, the effects have varied. Given potential of whole body training, this study aimed at exploring transmission vertical sinusoidal human over a wide range applicable amplitudes (from 0.05 3 mm) and frequencies 10 90 Hz). Vibration-induced accelerations were assessed with skin-mounted triaxial accelerometers ankle, knee, hip, lumbar spine four males standing on...
ObjectiveTo study the safety and tolerability of LymfactinⓇ treatment combined with microvascular lymph node transfer surgery in patients upper limb lymphedema.BackgroundUpper lymphedema is a common clinical challenge after breast cancer and/or radiotherapy. an adenovirus type 5–based gene therapy involving expression human vascular endothelial growth factor C (VEGF-C) damaged tissue. It aims to correct deficient lymphatic flow by promoting repair vessels.MethodsIn Phase I, was...
Introduction: An acute diabetic foot infection (DFI) is a serious condition and leading cause of hospitalization major amputation in patients with diabetes. Aim this study was to evaluate the long term survival risk factors for death after DFI requiring hospital treatment. Materials Methods: A retrospective included all adult hospitalized treatments during 2010–2014. Overall (OS) free (AFS) (without amputation) calculated. We performed Cox regression analysis several clinical parameters...
Lymphedema is a common problem after breast cancer treatment. Lymfactin® prolymphangiogenic growth factor vector inducing the expression of human vascular endothelial C (VEGF-C). It promotes and repair lymphatic vessels.Lymfactin® was combined with microvascular lymph node transfer surgery (VLNT) to study safety efficacy treatment in cancer-related upper limb lymphedema (BCRL) patients. This continuation 3 year 5 follow-up.Fifteen patients were recruited between June 2016 February 2018....
Soft tissue infections, including postoperative wound result in a significant burden for modern society. Rapid diagnosis of infections is based on bacterial stains, cultures, and polymerase chain reaction assays, the results are available earliest after several hours, but more often not until days after. Therefore, antibiotic treatment administered empirically without specific diagnosis.We employed our electronic nose (eNose) system this proof-of-concept study, aiming to differentiate most...
BACKGROUND: Breast cancer-related lymphedema (BCRL) is a common complication lacking medical treatment. Lymfactin® an adenovirus type 5-based gene therapy and prolymphangiogenic growth factor vector that induces vascular endothelial C (VEGF-C) expression. Our aim was to evaluate the therapeutic effect of Lymfactin ® with vascularized lymph node transfer (VLNT). METHODS: This Phase II, double-blind, placebo-controlled, randomized multicenter study evaluated efficacy safety in combination...
Diabetic foot syndrome is a global challenge best managed through multidisciplinary collaboration. This study aimed to investigate the effect of systematic team (MDT) on overall survival and major amputation-free hospitalized patients with diabetic infection (DFI). retrospective cohort was conducted at Tampere University Hospital. Cohorts DFI before after initiation wound ward were compared an 8-year follow-up. Kaplan-Meier analysis revealed significantly higher in post-MDT (37.8 % vs 22.6...
Whole-body vibration training (WBV) has shown positive effects on bone strength, muscle and balance, but the evidence fall prevention is not yet persuasive. This study aimed to evaluate effectiveness of WBV in preventing falls improving physical performance among older adults at risk. The was an assessor- participant-blinded, randomized, controlled 10-week trial with a 10-month follow-up. One hundred thirty (mean age 78.5 years, 75% women) were randomly allocated into group (
Vascularized lymph node transfer (VLNT) is one option among other surgical treatments in the management of breast cancer-related lymphedema (BCRL). The cause concern regarding VLNT harvested from groin has been potential development secondary lower-extremity lymphedema. This study explored risks associated with donor-site morbidity following VLNT, or without concomitant reconstruction.
Survival rates and local control after resection of a sarcoma the pelvis compare poorly to those limbs have high incidence complications. The outcome for patients who need hindquarter amputation (HQA) treat pelvic is poor. Our aim was evaluate patient, tumour, reconstructive factors that affect survival undergo HQA primary or recurrent sarcoma.We carried out retrospective review all had undergone in supraregional unit between 1996 2018. Outcomes included oncological, surgical,...
Open tibia fracture (OTF) causes a considerable increase in morbidity and risk for complications compared to closed fractures. The most significant OTF complication leading is commonly considered be fracture-related infection (FRI). In September 2016, Tampere University Hospital (TAUH) introduced treatment protocol OTFs based on the BOAST 4 guideline. aim of this study investigate outcomes before after implementation protocol.A retrospective cohort was conducted using handpicked data from...
The latissimus dorsi (LD) muscle flap is frequently used for free tissue transfer to reconstruct large defects of the extremities. As a flap, LD also can be harvested as muscle-sparing (MS-LD), preserving innervation and insertion remaining muscle. Conventional harvesting however, results in long scar on lateral back. Harvesting using an endoscopic approach minimizes donor site morbidity. We present our modified technique with CO2 insufflation standard instruments or MS-LD flap.Ten patients...
Background: Diabetic foot infection (DFI) is a severe complication of diabetes and leading cause hospitalization in the population with diabetes. Empirical intravenous antibiotic agents are initiated according to guidelines based on previously published data typical pathogens. Therefore, regular evaluation pathogens DFI their resistance important validate current therapies. We evaluated most bacterial cultures patients treated at our hospital for common agents, as well reliability...
Interest in functional outcome (FO) and health-related quality of life (HRQL) extremity soft-tissue sarcoma (STS) patients has increased. The aim this study was to validate two FO questionnaires for upper STS patients: the Toronto Extremity Salvage Score (TESS) short version Disability Arm, Shoulder Hand (QuickDASH), based on Finnish population data.A multi-center conducted at academic centers. Surgically treated were invited participate. Patients completed TESS QuickDASH with HRQL 15D...
Abstract Vasculitic and pyoderma gangrenosum ulcers are traditionally treated with immunosuppressants, the role of surgery in treatment these atypical remains unclear. This study aimed to investigate need for surgical intervention as well outcome safety skin grafting 46 patients vasculitic 34 using data recorded validated Wound Registry. Of 80 ulcers, 14% ( n = 11) were surgically; older p 0.039), had lower mobility status 0.002), more often pulmonary diseases, rheumatoid arthritis, previous...
This study investigates the outcomes of complex knee joint reconstructions performed by an orthoplastic surgery team at a tertiary referral hospital.Retrospective review all total arthroplasty (TKA)/revision TKA (rTKA) procedures with soft tissue flap reconstruction between 2008 and 2019 was conducted. Patients were stratified into two groups according to urgency surgery: scheduled non-complicated (SNC) emergent complicated (EC). The whole cohort also categorized non-infected infected...